Sleep, Melatonin, and the Menopausal Transition: What Are the Links?

Jehan, Shazia; Jean-Louis, G; Zizi, Ferdinand; Auguste, Evan; Pandi-Perumal, Seithikurippu R.; Gupta, Ravi; Attarian, Hrayr; McFarlane, Samy I.; Hardeland, Rüdiger; Brzezinski, Amnon

doi:10.5935/1984-0063.20170003

Cited by 36 publications

(36 citation statements)

References 105 publications

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“…These physiological activities include immunity, locomotive, sleep, reproduction, etc. (16)(17)(18)(19)(20)(21). These actions of melatonin have developed during different stages of evolution since bacteria do not require melatonin to transduce photoperiodic information.…”

Section: Introductionmentioning

confidence: 99%

Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells

2019

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It was a surprising discovery when mitochondria, as the power houses of cells, were also found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin synthetic enzyme serotonin N-acetyltransferase (SNAT) was found in matrix and also in the intermembrane space of mitochondria. We hypothesize that the melatonin synthesis occurs in the matrix due to substrate (N-acetyl co-enzyme A) availability while the intermembrane space may serve as the recycling pool of SNAT to regulate the melatonin circadian rhythm. Another surprise was that the melatonin membrane receptors, including MT1 and MT2, were also present in mitochondria. The protective effects of melatonin against neuronal injury induced by brain ischemia/reperfusion were proven to be mainly mediated by mitochondrial melatonin receptors rather than the cell surface membrane receptors which is contrary to the classical principle. In addition, melatonin metabolic enzyme has also been identified in the mitochondria. This enzyme can convert melatonin to N-acetylserotonin to strengthen the antitumor effects of melatonin. Thus, mitochondria are the generator, battle ground and metabolic sites of melatonin. The biological significance of the strong association between mitochondria and melatonin should be intensively investigated.

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Section: Introductionmentioning

confidence: 99%

Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells

2019

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“…Melatonin ( N -acetyl-5-methoxytryptamine) is a neurohormone primarily secreted from the pineal gland [ 3 , 4 ]. The functional effect of melatonin involves a wide spectrum of pathophysiological processes, including delaying senescence [ 5 ], anti-tumorigenesis [ 6 ], sleep melioration [ 7 ] and immune adjustment [ 8 ]. The function of melatonin is mainly mediated by its receptors, MT1 and MT2, classical G protein-coupled receptors [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway

Zhao

Sun

et al. 2018

IJMS

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Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial pneumonia with high mortality. Melatonin, a hormone predominantly secreted by the pineal gland, has been reported to participate in the process of IPF. However, the mechanisms underlying the effect of melatonin in pulmonary fibrosis have not been elucidated to date. This study was designed to evaluate the anti-fibrotic role of melatonin in pulmonary fibrosis and to elucidate the potential mechanisms. We observed that melatonin markedly attenuated bleomycin (BLM)-induced experimental lung fibrosis in mice and inhibited TGF-β1-induced fibrogenesis in lung fibroblasts. Additionally, we determined that luzindole, a melatonin receptor inhibitor, reduced the anti-fibrotic effect of melatonin. Further studies showed that melatonin alleviated the translocation of YAP1 from cytoplasm to nucleus, a key downstream effector of the Hippo pathway, in vivo and in vitro by interacting with its receptor. Taken together, our results suggest that melatonin prevents lung fibrosis by inhibiting YAP1 and indicate that melatonin replacement could be a novel strategy for the treatment of lung fibrosis.

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“…A decline in the levels of these hormones in menopausal and postmenopausal women and the complex interaction among these hormones can significantly contribute to sleep problems. 35,50 The sleep problems occurring in later phases of cancer are characterized by comorbidities such as depression, deviations in breathing, or fibromyalgia, and progressively by age-associated processes. Insomnia is a frequent complaint among breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

<p>Depressive Symptoms, Sleep Profiles and Serum Melatonin Levels in a Sample of Breast Cancer Patients</p>

Zaki

Sabri

Farouk

et al. 2020

NSS

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Background: Chronobiological changes have been detected in various physiological functions of patients with breast cancer, suggesting dysregulation in the pineal gland and melatonin secretion. This study aimed to assess and measure serum melatonin levels preand postoperatively in patients who had been diagnosed for the first time with breast cancer. Methods: A sample of first-time breast cancer patients, consisting of 45 women aged 25-65 years, was evaluated and psychometric assessment was completed using the Beck Depression Inventory (BDI), Insomnia Severity Index (White, Weinberg et al) and the Epworth Sleepiness Scale (Cardoso, Spence et al). The Morningness-Eveningness questionnaire (MEQ) was used to assess the chronotype. Serum melatonin levels were measured by radioimmunoassay. Results: Morning and moderately morning chronotypes were prevalent among the sample (25%, 45.8%, respectively). The finding of a mean BDI score of 13.5±11.2 indicated that depressive symptoms were prevalent among the sample. Despite the finding that a mean of the participants apparently had no symptoms of daytime sleepiness (the mean and standard deviations of the ESS were 7.5±4.4), scores on the ISI (a mean of 16.7±SD 7.3) indicated that insomnia symptoms were prevalent in the sample. Melatonin levels showed an inverse relationship with insomnia severity as measured by the ISI and depression severity, as assessed by the BDI. The postoperative melatonin levels were higher than the preoperative levels. Additionally, the psychometric profile differed among various pathological types of breast cancer according to their hormone receptor profile. Conclusion: Serum melatonin levels correlated significantly with self-reported sleep quality and psychometric profiles of depression in the present sample of breast cancer patients. The melatonin assay, which is relatively easy to carry out, provided a convenient, objective measure of an important biological correlate of sleep quality and depression. This assay thus represented a confirmatory alternative to the self-report instruments, which may sometimes be unreliable. Future studies should further evaluate the utility of melatonin measures in psychiatric and sleep complaints of breast cancer patients.

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Sleep, Melatonin, and the Menopausal Transition: What Are the Links?

Cited by 36 publications

References 105 publications

Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells

Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells

Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway

<p>Depressive Symptoms, Sleep Profiles and Serum Melatonin Levels in a Sample of Breast Cancer Patients</p>

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