Sleep patterns in children with and without autism spectrum disorders: Developmental comparisons

Hodge, Danelle; Carollo, Tanner M.; Lewin, M. R.; Hoffman, Charles D.; Sweeney, Dwight P.

doi:10.1016/j.ridd.2014.03.037

Cited by 132 publications

(119 citation statements)

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“…Low levels of melatonin have been associated with GABAergic system [7]. Gamma-Amino Butyric acid (GABA) is the main inhibitory neurotransmitter of the CNS.…”

Section: Effect Of Melatonin Treatment For Cognitive-learning Disabilmentioning

confidence: 99%

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Melatonin as an Interventional Novel Candidate for the Individual with Autistic Fragile X Syndrome in Human

Won

Jin

Lee

et al. 2017

Preprint

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Fragile X syndrome (FXS) is the most frequent monogenic form of autism spectrum disorder (ASD). Autistic FXS is caused by loss of the fmr1 gene product, the fragile X mental retardation protein (FMRP), triggering physiological and behavioral abnormalities. It is correlated with clock components for behavioral circadian rhythm. Mutation of this gene causes the disturbances in sleep patterns and circadian behavior commonly observed in patients with autistic FXS, accompanied by frequent dysregulation of melatonin synthesis and melatonin-dependent signaling. These changes impair vigilance, learning and memory, and are also linked to autistic behavior including the abnormal anxiety response. However, although several possible causes, symptoms, and clinical features of ASD have been investigated, the correlation between an altered circadian rhythm and autistic FXS has not been extensively studied. Recent works have highlighted the impact of melatonin on the nervous, immune, and metabolic systems. Even though utilization of melatonin for sleep disorder in ASD has been considered in clinical research, further studies should be aimed at its neuroprotective role in ASD during developmental period. In this review, we focus on the regulatory circuits involved in melatonin dysregulation and circadian system disruption in those with autistic FXS. Additionally, we discuss the neuroprotective effect of melatonin intervention. This may improve neuroplasticity and physical capability. We also review the underlying molecular mechanisms, and suggest that melatonin may be a useful novel treatment for autistic FXS, countering the adverse effects of circadian variation.

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“…Low levels of melatonin have been associated with GABAergic system [7]. Gamma-Amino Butyric acid (GABA) is the main inhibitory neurotransmitter of the CNS.…”

Section: Effect Of Melatonin Treatment For Cognitive-learning Disabilmentioning

confidence: 99%

“…Sleep disorder is general problem in children with ASD and also reported in up to 77% of children with FXS [5][6][7]. Furthermore, the occurrence of sleep disorder with FXS is associated with impaired vigilance, learning, and memory and also linked to autistic behavior with abnormal anxiety response [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Melatonin as an Interventional Novel Candidate for the Individual with Autistic Fragile X Syndrome in Human

Won

Jin

Lee

et al. 2017

Preprint

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“…The prevalence of sleep disorders among children with ASDs is estimated to range from 45% to 86% (Liu, Hubbard, Fabes, & Adam, 2006;Maskey et al, 2013), with the majority of studies reporting that more than half of children with ASDs have at least one sleep problem (Allik et al, 2006;Giannotti et al, 2008;Hodge, Carollo, Lewin, Hoffman, & Sweeney, 2014;Krakowiak, GoodlinJones, Hertz-Picciotto, Croen, & Hansen, 2008;Liu et al, 2006;Mayes & Calhoun, 2009;Patzold, Richdale, & Tonge, 1998;Polimeni, Richdale, & Francis, 2005). Sleep disorders among children with ASDs are also more chronic in nature than in children without ASDs.…”

Section: Prevalence Of Comorbid Sleep Disordersmentioning

confidence: 99%

“…Children with ASDs are also reported to have an increased number of nighttime awakenings (Hodge at al., 2014), as well as nighttime awakenings of significantly longer duration than typically developing children (Giannotti, Cortesi, Cerquiglini, & Bernabei, 2006;Limoges et al, 2005). Children with ASDs are reported to wake earlier than do typically developing peers (DeVincent, Gadow, Delosh, & Geller, 2007), with one study finding that as many as 45% of children with an ASD experience early morning waking (Mayes & Calhoun, 2009).…”

Section: Insomniamentioning

confidence: 99%

“…Other sleep problems experienced by children with ASDs include parasomnias such as sleep walking, sleep talking, bruxism, night terrors, and sleep-related movement disorders such as restless leg syndrome (Giannotti et al, 2008;Ming, Sun, Nachajon, Brimacombe, & Walters, 2009;Tsai et al, 2012), as well as bedtime resistance (Giannotti et al, 2008;Hodge et al, 2014), and strange bedtime routines (Patzold et al, 1998). Because of the high prevalence of sleep problems, a complete problem assessment needs to be performed, including risk factors.…”

Section: Parasomniasmentioning

confidence: 99%

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Counting Sheep: Sleep Disorders in Children With Autism Spectrum Disorders

Herrmann¹

2016

Journal of Pediatric Health Care

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Age-Related Differences in Accelerometer-Assessed Physical Activity and Sleep Parameters Among Children and Adolescents With and Without Autism Spectrum Disorder

Liang,

Haegele,

Healy

et al. 2023

JAMA Netw Open

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ImportancePhysical inactivity and sleep disorders are health-related concerns of youth with autism spectrum disorder (ASD) that can persist from childhood and exacerbate core symptoms. However, evidence on group differences in accelerometer-assessed physical activity and sleep parameters among youth with and without ASD is inconclusive and age-specific effects remain unclear.ObjectiveTo synthesize evidence on group differences in accelerometer-assessed physical activity and sleep parameters and examine the moderating effects of age between children and adolescents with and without ASD.Data SourcesAmerican Psychological Association PsychInfo, CINAHL Ultimate, ERIC, MEDLINE, SPORTDiscus with Full Text, and Web of Science from inception to February 2023.Study SelectionTwo independent reviewers screened articles for observational research comparing accelerometer-assessed physical activity levels and sleep parameters in children and adolescents with and without ASD.Data Extraction and SynthesisAfter developing a standardized form, relevant data were extracted. Quality was assessed using the McMaster Critical Review Form and rated based on sample, measurement, and analyses. The Preferring Reporting Items for Systematic Reviews and Meta-Analyses guideline was followed.Main Outcomes and MeasuresThe primary outcomes were actigraphy-measured MVPA, sleep latency, sleep efficiency, total sleep time, and wake after sleep onset. Data were pooled using a random-effects model. Hedges g was used to express the effect size index. Meta-regression on age was also performed to investigate the potential moderating effects.ResultsCollectively, 1757 studies were initially identified. Among 104 articles that were assessed, 28 were included, comprising moderate-to-vigorous physical activity (MVPA), 4 sleep parameters, and 73 independent effect sizes. A total of 28 studies were included in analysis, comprising 805 children and adolescents with ASD and 1573 without ASD (age range, 5.1-16.9 years). Compared with peers without ASD, children and adolescents with ASD had a small-to-moderate difference in MVPA (g = −0.450; 95% CI, −0.622 to −0.277), total sleep time (g = −0.332; 95% CI, −0.574 to −0.090), sleep efficiency (g = −0.424; 95% CI, −0.645 to −0.203), and a moderate difference in sleep latency (g = 0.514; 95% CI, 0.351 to 0.677) measured by actigraphy. Children and adolescents with ASD experienced an age-related decline in moderate-to-vigorous physical activity (β = −0.049 [95% CI, −0.097 to −0.001]; P = .045), indicating that younger children with ASD showed a smaller difference in MVPA compared with their peers without ASD. Moderating effects of age on sleep parameters were not significant.Conclusions and RelevanceThe findings of this meta-analysis suggested that children and adolescents with ASD had lower MVPA and worse sleep than peers without ASD, and the difference in MVPA varied with age. These findings reinforce the need for public health initiatives aimed at reducing these group disparities.

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Sleep patterns in children with and without autism spectrum disorders: Developmental comparisons

Cited by 132 publications

References 34 publications

Melatonin as an Interventional Novel Candidate for the Individual with Autistic Fragile X Syndrome in Human

Melatonin as an Interventional Novel Candidate for the Individual with Autistic Fragile X Syndrome in Human

Counting Sheep: Sleep Disorders in Children With Autism Spectrum Disorders

Age-Related Differences in Accelerometer-Assessed Physical Activity and Sleep Parameters Among Children and Adolescents With and Without Autism Spectrum Disorder

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