Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model?

Benedetti, Francesco; Barbini, Barbara; Campori, Euridice; Fulgosi, Mara Cigala; Pontiggia, Adriana; Colombo, Cristina

doi:10.1016/s0022-3956(01)00034-6

Cited by 96 publications

(47 citation statements)

References 34 publications

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“…Sleep following treatment can lead to a relapse in symptoms, however, in some patients this is delayed for several weeks. Concurrent treatment with antidepressant medications or lithium may help prevent relapse (Wu and Bunney, 1990;Benedetti et al, 2001). Furthermore, follow up treatment with daily light therapy or a short phase advance in the sleep/wake cycle can also prevent relapse (Berger et al, 1997;Riemann et al, 1999;WirzJustice et al, 2005).…”

Section: Treating Mood Disorders By Altering the Circadian Cycle 41 mentioning

confidence: 99%

“…Furthermore, patients that have a shift in rhythms respond positively to lithium treatment in terms of mood stabilization, while those few bipolar patients that begin with an abnormally slow clock do not respond to lithium treatment. Furthermore, lithium treatment is able sustain and enhance the phase-shifting and mood-altering effects of TSD (Benedetti et al, 2001). …”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

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Circadian genes, rhythms and the biology of mood disorders

McClung

2007

Pharmacology & Therapeutics

587

386

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For many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder, major depression and seasonal affective disorder. Furthermore, some of the treatments that are currently employed to treat mood disorders are thought to act by shifting or "resetting" the circadian clock, including total sleep deprivation and bright light therapy. There is also reason to suspect that many of the mood stabilizers and antidepressants used to treat these disorders may derive at least some of their therapeutic efficacy by affecting the circadian clock. Recent genetic, molecular and behavioral studies implicate individual genes that make up the clock in mood regulation. As well, important functions of these genes in brain regions and neurotransmitter systems associated with mood regulation is becoming apparent. In this review, the evidence linking circadian rhythms and mood disorders, and what is known about the underlying biology of this association, is presented.

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Section: Treating Mood Disorders By Altering the Circadian Cycle 41 mentioning

confidence: 99%

Section: Pharmacological Treatmentsmentioning

confidence: 99%

Circadian genes, rhythms and the biology of mood disorders

McClung

2007

Pharmacology & Therapeutics

587

386

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“…Several independent trials consistently reported synergistic effects of the combination of SD with light therapy [48,50,84,85] and/or subsequent sleep phase advance [77,[86][87][88][89] .…”

Section: Interactions With Other Treatments: the Need For Combined Anmentioning

confidence: 99%

Sleep Deprivation in Mood Disorders

2011

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Growing clinical evidence in support of the efficacy and safety of sleep deprivation (SD), and its biological mechanisms of action suggest that this technique can now be included among the first-line antidepressant treatment strategies for mood disorders. SD targets the broadly defined depressive syndrome, and can be administered according to several different treatment schedules: total versus partial, single versus repeated, alone or combined with antidepressant drugs, mood stabilizers, or other chronotherapeutic techniques, such as light therapy and sleep phase advance. The present review focuses on clinical evidence about the place of SD in therapy, its indications, dosage and timing of the therapeutic wake, interactions with other treatments, precautions and contraindications, adverse reactions, mechanism of action, and comparative efficacy, with the aim of providing the clinical psychiatrist with an updated, concise guide to its application.

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“…Other kinds of sleep intervention have also displayed some therapeutic effectiveness for bipolar patients (e.g., Wehr et al, 1998). Benedetti et al (2001) found that the effectiveness of a sleep intervention was additionally enhanced when participants were simultaneously treated with lithium. Lithium (commonly prescribed as a mood stabilizer) is thought to delay the phase of circadian rhythms (time at which the rhythm peaks) and, hence, the combination of advancing sleep onset and delaying circadian rhythms may help synchronize an abnormal phase alignment between the sleep-wake cycle and the body clock.…”

Section: Treatment Of Bipolar Disordersmentioning

confidence: 99%

Restructuring mood in cyclothymia using cognitive behavior therapy: an intensive time‐sampling study

Totterdell

Kellett²

2008

J Clin Psychol

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Hypotheses predicting how cognitive behavioral therapy (CBT) would change the daily pattern of mood and sleep in a patient with cyclothymia were formulated based on circadian processes. Using a prospective single-case experimental design, the patient provided mood ratings every 4 hours and sleep reports daily for 49 weeks, including a 4-week baseline, a 20-session CBT intervention, and a follow-up period. Improvements in mood during and after therapy were accounted for by reduced daily mood variability and extended sleep. The patient's energy at different times of day was explained by adjusting the endogenous rhythm in a mathematical circadian model. Treatment of cyclothymia and related bipolar disorders may be enhanced by integrating understanding of circadian mood regulation into CBT treatment.

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Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model?

Cited by 96 publications

References 34 publications

Circadian genes, rhythms and the biology of mood disorders

Circadian genes, rhythms and the biology of mood disorders

Sleep Deprivation in Mood Disorders

Restructuring mood in cyclothymia using cognitive behavior therapy: an intensive time‐sampling study

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