Sleep Profile in Opioid Dependence

Mehtry, Vijay; Nizamie, S. Haque; Parvez, Nizamuddin; Pradhan, N.

doi:10.1097/wnp.0000000000000117

Cited by 23 publications

(2 citation statements)

References 37 publications

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“…Our results showed that an earlier age at the onset of heroin exposure predicted the subsequent onset of CPSD. Although a previous study demonstrated no association between the age at onset of heroin use and sleep disturbance, 39 it has also been reported that patients with long-term opioid use frequently have severe sleep-disordered breathing, which in part is central in origin. 40 , 41 Furthermore, a longer duration of MMT has been significantly correlated with obstructive sleep apnea.…”

Section: Discussionmentioning

confidence: 82%

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Li¹,

Chung²,

Wu³

et al. 2018

NDT

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IntroductionSleep disturbance is a major health concern for heroin users receiving methadone maintenance treatment (MMT). The present study was aimed to investigate the predictors for new-onset clinically predominant sleep disturbance (CPSD) among heroin users receiving MMT.MethodsThis 2-year retrospective study included 152 individuals (127 males and 25 females) with heroin use disorder who visited our MMT clinics for the first time. A univariate Cox proportional hazards regression model (Cox model) was used to estimate the potential factors of subsequent CPSD, followed by a multivariate Cox model to identify significant predictors of CPSD after adjusting for other covariates.ResultsTwenty-nine (19.1%) participants developed CPSD during the 2-year period. After forward selection in the Cox model, earlier age at onset of heroin exposure (OR=0.95; P=0.044), lower attendance rate (OR =0.04; P=0.03), greater maximum dose of methadone (OR =1.01; P=0.022), and shorter time to maximum methadone dose (OR =0.98; P=0.007) were significantly associated with new-onset CPSD.ConclusionWe identified predictors that were significantly associated with new-onset CPSD, and clinicians should be aware of sleep disturbance in heroin users receiving MMT with these risk factors. Future studies are necessary to verify our findings and extend the applicability.

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Section: Discussionmentioning

confidence: 82%

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Li¹,

Chung²,

Wu³

et al. 2018

NDT

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“…Previously, reductions in total sleep time were found in patients withdrawing from non-prescription opioids (Hartwell et al, 2014). Mehtry et al in a case-control study documented that opioid-dependent patients experienced decreases in total sleep time after one week of abstinence (Mehtry, Nizamie, Parvez, & Pradhan, 2014). In could be concluded that abstinence might not worsen opioid craving but did reduce total sleep time.…”

Section: Discussionmentioning

confidence: 96%

Effects of abstinence from opioids on self-reported craving and sleep

et al. 2020

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Abstinence-based treatment of opioid use disorder has always been faced with the probability of an increase in craving, which potentially results in relapse. Moreover, sleep problems are predominant among patients with abstinence treatment. A sample of twenty-six male subjects with opioid use disorder were selected from a residential treatment center for substance use disorders in 2017 in Mashhad, Iran. Opioid craving was evaluated using obsessive-compulsive drug use scale (OCDUS) at four-time points (days 1, 10, 20, and 30) during abstinence. Also, they were asked to report their total sleep time. The participants with an average age of 32.5 ± 8.0 years reported the use of opium and heroin to be as high as 2.0 ± 1.2 g per day and 1.5 ± 0.9 g per day, respectively. Abstinence induced a non-significant gradual decrease in selfreported craving during one month (p > 0.05). Also, they experienced significant declines in total sleep time over the first ten days (p = 0.008). The univariate analysis of variance showed no significant changes in craving after adjustment for total sleep time (p > 0.05). Insignificant reductions in opioid craving after detoxification persisted throughout the 30 days of abstinence.

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A prospective, longitudinal study of sleep disturbance and comorbidity in opiate dependence (the ANRS Methaville study)

et al. 2016

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Sleep Profile in Opioid Dependence

Abstract: Use of opioids cause sleep disturbance, and these changes occurring in sleep can persist even after substance use has been stopped. Opioids seem to affect non-rapid eye movement stages of sleep.

Cited by 23 publications

References 37 publications

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Effects of abstinence from opioids on self-reported craving and sleep

A prospective, longitudinal study of sleep disturbance and comorbidity in opiate dependence (the ANRS Methaville study)

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