Sleep quality and daytime function in adults with cystic fibrosis and severe lung disease

Dancey, David R.; Tullis, Elizabeth; Heslegrave, Ronald J.; Thornley, Kristine S.; Hanly, Patrick J.

doi:10.1183/09031936.02.00088702

Cited by 89 publications

(86 citation statements)

References 29 publications

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“…Secondly, our control subjects were children and adolescents who underwent a sleep study in our sleep laboratory and were found to have normal study. [5,[14][15][16]. All of these studies focused only on adult population.…”

Section: Discussionmentioning

confidence: 97%

“…Spier et al [7] demonstrated that CF patients had reduced SE and REM sleep. In addition, sleep disruption and subsequent impairment in daytime function were found to be related to nocturnal hypoxemia [5]. However, there is little data on the sleep quality and sleep architecture in children with CF.…”

Section: Introductionmentioning

confidence: 98%

“…Sleep quality and daytime function in adult patients with CF have been examined. Dancey et al [5] reported decreased sleep efficiency (SE) and frequent awakening during sleep but no significant change in sleep stages in adult patients with CF. Spier et al [7] demonstrated that CF patients had reduced SE and REM sleep.…”

Section: Introductionmentioning

confidence: 98%

“…Several factors can lead to disturbed sleep and sleep fragmentations in these patients including nocturnal hypoxia, hypoventilation, chronic cough, chronic inflammation, and medication effects [5,6]. Sleep quality and daytime function in adult patients with CF have been examined.…”

Section: Introductionmentioning

confidence: 99%

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Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease

et al. 2007

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Previous studies have shown that sleep complaints are common in adult patients with cystic fibrosis (CF). However, there is very little data on sleep in children and adolescents with CF and the association with severity of lung disease. A prospective study was conducted in CF children and age-matched controls. All patients completed sleep questionnaire and underwent an overnight polysomnographic study. Thirty-eight children and adolescents met the criteria for entry into the analysis, 24 children and adolescents with CF (S) and 14 controls (C). Sleep complaints were common in children and adolescents with CF; 43.5% reported sleep onset problem, 39.1% reported sleep maintenance problem, 30.4% were noted to snore at night, and 73.9% reported daytime sleepiness. Children and adolescents with CF had a significant decrease in sleep efficiency [SE; 75.2 +/- 2.5% (S) vs 85.6 +/- 1.7%(C); P < 0.01], prolonged rapid eye movement (REM) latency [150.5 +/- 16.6 min (S) vs 85.6 +/- 11.0 min (C); P < 0.05], and reduction in percentage of REM sleep [12.7 +/- 1.5% (S) vs 18.3 +/- 1.3% (C); P < 0.05]. The degree of sleep disruption as indicated by SE was correlated with forced expiratory volume in one second (FEV(1); r = 0.52, P < 0.05). However, there was no significant correlation between SE and minimum oxygen saturation [r = 0.30, P=not significant (NS)] or SE and maximal end-tidal pCO(2) (r = 0.11, P=NS). It is concluded that children and adolescents with CF have frequent sleep complaints and significant alteration in the sleep architecture. The magnitude of sleep disruption is associated with severity of lung disease, but is not directly correlated with the degree of nocturnal hypoxemia or hypoventilation. It is speculated that sleep disruption in children and adolescents with CF may have an impact on quality of life and clinical outcomes in this population.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease

et al. 2007

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“…Existem poucos estudos que abordam a arquitetura do sono na população de pacientes com FC e sobre a prevalência de DRS em pacientes com FC, especialmente de SAOS em crianças com FC 5 . A maioria dos dados publicados na literatura sobre DRS e FC baseia-se em estudos com populações mais velhas: pacientes no final da adolescência ou adultos jovens 18 . O presente estudo avaliou uma população de pacientes mais jovem (mediana da idade de 8 anos, amplitude de 5 a 10 anos).…”

Section: Discussionunclassified

Arquitetura do sono e perfil respiratório polissonográfico de crianças e adolescentes com fibrose cística

Ramos¹,

Salles²,

Daltro³

et al. 2011

J Pediatr (Rio J)

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Objectives: To evaluate sleep architecture in children and adolescents with both cystic fibrosis (CF) and a clinical suspicion of sleep-disordered breathing (SDB), and to identify the respiratory polysomnographic profile of these patients.Methods: Parents or guardians of children with CF filled out a questionnaire designed to assess their clinical and sleep conditions. Children who were identified as having behaviors associated with SDB underwent polysomnography. After polysomnography, patients were grouped according to the obstructive apnea index (AI) obtained (either < 1 or ≥ 1), and a multiple correspondence factor analysis was used to analyze and identify the polysomnographic profile of patients. Results:Of the 74 patients who met inclusion criteria for this study, 67 underwent polysomnography, and 38 (56.7%) of the 67 patients showed an AI ≥ 1. Median age was 8 years. The group of patients with an AI ≥ 1 was characterized by total sleep time (TST) during stage 4 and rapid eye movement (REM) stage of sleep < 21 and 13%, respectively, REM sleep latency > 144 minutes, percentage of TST with pulse oxyhemoglobin saturation (SpO 2 ) < 90% higher than 0.28 seconds, and an oxygen desaturation index higher than 0.92. Conclusion:Results suggest that clinically stable pediatric patients with CF have a high prevalence of SDB and present frequent sleep complaints, significant changes in sleep architecture, and episodes of oxygen desaturation during sleep.J Pediatr (Rio J). 2011;87(1):63-69:: Cystic fibrosis, children, adolescents, polysomnography, obstructive sleep apnea. ResumoObjetivos: Avaliar a arquitetura do sono em crianças e adolescentes com fibrose cística (FC) e com suspeita clínica de distúrbios respiratórios do sono (DRS), e identificar o perfil respiratório polissonográfico desses pacientes. Métodos:Os pais ou responsáveis dos pacientes com FC preencheram um questionário que abordava questões clínicas e relacionadas ao sono.As crianças e adolescentes que foram identificadas com quadro clínico sugestivo de DRS foram submetidas a polissonografia. Após a realização da polissonografia, os pacientes foram agrupados de acordo com o índice de apneia obstrutiva (IA) observado (< 1 ou ≥ 1) e utilizou-se a análise fatorial de correspondência múltipla para análise e identificação dos perfis polissonográficos dos pacientes.Resultados: Dos 74 pacientes que preencheram os critérios de inclusão para este estudo, 67 foram submetidos à polissonografia; observou-se que 38 (56,7%) dos 67 pacientes apresentaram um IA ≥ 1. A mediana das idades foi de 8 anos. O grupo de pacientes com IA ≥ 1 caracterizou-se por apresentar tempo total de sono (TTS) nos estágios 4 e no REM < 21 e 13%, respectivamente, latência do sono REM > 144 minutos, o percentual de TTS com saturação da oxi-hemoglobina medida por oximetria de pulso (SpO 2 ) < 90% maior que 0,28 segundos e o índice de dessaturação de oxigênio maior que 0,92. Conclusão:Os resultados sugerem que pacientes pediátricos clinicamente estáveis com FC têm uma alta prevalência de D...

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Early Occurrence of Obstructive Sleep Apnea in Infants and Children With Cystic Fibrosis

Spicuzza¹,

Sciuto²,

Leonardi³

et al. 2012

Arch Pediatr Adolesc Med

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To assess the occurrence of sleepdisordered breathing, hypoxemia, and sleep architecture in a cohort of infants and children with cystic fibrosis (CF) and normal or mildly impaired lung function in stable clinical condition. Design: Case-control study. Setting: Cystic Fibrosis Unit of a university hospital and pediatric sleep laboratory. Participants: A total of 40 children (aged 6 months to 11 years) with CF in stable condition and 18 healthy agematched control subjects. Intervention: Nocturnal sleep and cardiorespiratory monitoring was performed using a full polysomnographic recording in a sleep laboratory. Main Outcomes Measures: Sleep architecture and respiratory variables. Results: Although awake oxyhemoglobin saturation (SaO 2) values were similar in the 2 groups (98%), the CF group had significantly lower values of nocturnal mean SaO 2. The apnea-hypopnea index was significantly higher in the CF group compared with the controls (mean [SE], 7.3 [1.3] vs 0.5 [0.4], respectively, P Ͻ .001), particularly in preschool-aged children and in children with upper airway abnormalities. In addition, 28 (70%) of the 40 children with CF had mild to moderate obstructive sleep apnea (defined as an apnea-hypopnea index Ͼ2). Children with CF compared with controls also had reduced sleep efficiency (CF group vs controls mean [SE], 80% [41%] vs 88% [13.1%], P Ͻ.001), rapid eye movement sleep duration (11% [0.9%] vs 13% [1%], PϽ.05), and increased number of arousals per hour (11.0 [10] vs 8.2 [0.7], P Ͻ.001). Conclusions: This study showed an early occurrence of obstructive sleep apnea in children with CF in stable condition, associated with a mild level of sleep disruption. Early routine nocturnal respiratory monitoring is advised in children with CF.

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Sleep quality and daytime function in adults with cystic fibrosis and severe lung disease

Cited by 89 publications

References 29 publications

Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease

Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease

Arquitetura do sono e perfil respiratório polissonográfico de crianças e adolescentes com fibrose cística

Early Occurrence of Obstructive Sleep Apnea in Infants and Children With Cystic Fibrosis

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