Sleep quality during pregnancy: associations with depressive and anxiety symptoms

Polo‐Kantola, Päivi; Aukia, Linda; Karlsson, Hasse; Karlsson, Lena; Paavonen, E. Juulia

doi:10.1111/aogs.13056

Cited by 104 publications

(89 citation statements)

References 32 publications

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“…CLOCK hyper‐methylation and CRY1, PER1, and PER2 hypo‐methylation are suggestive of a delay in circadian rhythms that is typical of pregnant women with a history of MDD as showed by shifts in dim light melatonin onset . We hypothesize that depression in pregnancy causes a further delay of circadian rhythms (already present in physiological pregnancy) . The dysregulation of the methylation of clock genes in depressed pregnant women is coincident with potential immunological abnormalities caused by a hyper‐methylation of FOXp3 .…”

Section: Different Degree Of Methylation (And Consequent Expression) mentioning

confidence: 88%

The role of clock genes in perinatal depression: the light in the darkness

Buoli

Grassi

Iodice

et al. 2019

Acta Psychiatr Scand

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Section: Different Degree Of Methylation (And Consequent Expression) mentioning

confidence: 88%

The role of clock genes in perinatal depression: the light in the darkness

Buoli

Grassi

Iodice

et al. 2019

Acta Psychiatr Scand

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“…Sut et al [9] and Facco et al [10] indicated that the risk of poor sleep quality increased in the second and third trimester when compared with the first trimester. Depression symptom was previously indicated to be associated with sleep disturbances during pregnancy [11]. Prenatal depression as well as postpartum depression were strongly linked with sleep quality [12].…”

Section: Introductionmentioning

confidence: 96%

Determinants of sleep quality among pregnant women in China: A cross-sectional survey

Ying¹,

Mao²,

Ye³

et al. 2017

Nurs Palliat Care

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“…Approximately one-fourth of pregnant women report sleepiness in mid-and late pregnancy [6]. While the frequency of sleep disturbances increases as the pregnancy proceeds, the frequency of sleepiness seems to remain stable over mid-and late pregnancy [6]. Thus, it is possible that sleepiness in pregnancy may not totally result from disrupted sleep [6].…”

Section: Discussionmentioning

confidence: 99%

“…While the frequency of sleep disturbances increases as the pregnancy proceeds, the frequency of sleepiness seems to remain stable over mid-and late pregnancy [6]. Thus, it is possible that sleepiness in pregnancy may not totally result from disrupted sleep [6]. Inflammatory mechanisms, especially cytokine IL-6, have been related -in non-pregnant populations-to daytime fatigue in the absence and the presence of medical conditions, e.g.…”

Section: Discussionmentioning

confidence: 99%

Maternal tiredness and cytokine concentrations in mid-pregnancy

Kaartinen

Karlsson

Paavonen

et al. 2019

Journal of Psychosomatic Research

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Sleep disturbances relate to altered levels of inflammatory mediators in general population, but not much is known about the associations between sleep disturbances and inflammatory mediators during pregnancy. The present exploratory study investigated whether insomnia, tiredness, general sleep quality, and insufficient sleep duration during pregnancy relate to the concentrations of maternal peripheral circulating cytokines. As sleep disturbances are frequently observed in mood disorders, the results were controlled for symptoms of depression and anxiety. Methods: 137 participants were randomly drawn from a representative FinnBrain Birth Cohort. Serum concentrations of selected cytokines were analyzed using Multiplex bead arrays from blood samples drawn at the gestational week 24. The sleep disturbances were evaluated using the Basic Nordic Sleep Questionnaire. Depressive and anxiety symptoms were measured with the Edinburgh Postnatal Depression Scale and the anxiety subscale of the self-rated Symptom Checklist 90, respectively. Results: Enhanced tiredness was associated with cytokine concentrations of IL-2, IL-10, IL-12, IL-13, and TNF-α. The observed associations resembled a reversed U-shaped curve rather than being linear. Having a good general sleep quality was associated with higher logarithmic cytokine concentrations of IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, and IFN-γ. There was no evidence for associations between insomnia or sleep loss and cytokines. Conclusions: Maternal subjective tiredness and good general sleep quality were associated with altered levels of immunological markers during pregnancy. The association was independent from symptoms of depression and anxiety. wake hours [5,6]. Increased rates of fatigue and sleepiness are frequently observed throughout normally progressing pregnancies [4,6,7]. Reportedly, women also take more naps during pregnancy compared to non-pregnant women [3,4]. Cytokines are signaling proteins of the immune system that are stimulated by infections and other types of inflammation, psychological stress, as well as sleep disturbances [8-14]. Cytokines may be further divided into proinflammatory T-helper 1 lymphocyte produced cytokines (Th1 cytokines, such as IFN-γ, IL-6, and IL-12) and anti

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Sleep quality during pregnancy: associations with depressive and anxiety symptoms

Cited by 104 publications

References 32 publications

The role of clock genes in perinatal depression: the light in the darkness

The role of clock genes in perinatal depression: the light in the darkness

Determinants of sleep quality among pregnant women in China: A cross-sectional survey

Maternal tiredness and cytokine concentrations in mid-pregnancy

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