Sleep quality, latency, and sleepiness are positively correlated with depression symptoms of Brazilians facing the pandemic-associated stressors of COVID-19

Garbuio, Ana Luíza Paula; Carvalhal, Talita Albertin Oliveira; Tomcix, Mariana Fatima Ribeiro; Reis, Ivan Gustavo Masselli dos; Messias, Leonardo Henrique Dalcheco

doi:10.1097/md.0000000000028185

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…It was intriguing to observe that ESS significantly improved, and the BDI score was not worsened during the follow-up, which happened during the SARS-CoV-2 pandemic, as these were described as common during this period [ 24 , 25 ]. We hypothesize that the changes in habits during the pandemic, mainly working habits (including less time spent in commute due to working from home), might be responsible for these findings.…”

Section: Discussionmentioning

confidence: 99%

Follow-up of pre-motor symptoms of Parkinson’s disease in adult patients with Gaucher disease type 1 and analysis of their lysosomal enzyme profiles in the CSF

Wilke,

Poswar,

Borelli

et al. 2023

Orphanet J Rare Dis

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Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Its classic motor symptoms may be preceded by non-motor symptoms (NMS). Population studies have identified GBA variants as risk factors for idiopathic PD. The increased risk of PD has also been suggested in other Lysosomal Storage Disorders (LSDs). Objective: To assess the evolution of the prevalence of NMS compatible with PD in a cohort of South Brazilian adult patients with Gaucher Disease (GD) type 1, already evaluated 3 years ago (2018). Cerebrospinal Fluid (CSF) was collected to assess the levels of LSD enzymes (beta-hexosaminidases, beta-glucuronidase) and biomarker of macrophage activation (chitotriosidase, ChT), compared to controls (metachromatic leukodystrophy, MLD). Cognition was evaluated by the Montreal Cognitive Assessment (MoCA) questionnaire, daytime sleepiness by the Epworth Sleepiness Scale (ESS), depression by Beck´s Inventory, constipation by the Unified Multiple System Atrophy Rating Scale (UMSARS) scale, and REM sleep behavior disorder by the single-question screen. Hyposmia was assessed with Sniffin’ Sticks (SST). Results Nineteen patients completed the follow-up (mean age of the sample was 44 years; range, 26–71). The patient with the highest number of NMS at the baseline (4 including the lowest SST score) was diagnosed with PD four years later. Apart from an improvement in the ESS score, no other statistical significance was found between the number of NMS between the first and second evaluation, nor between patients with one L444P variant (n = 5) and the rest of the cohort. CSF was collected in five patients (mean age of the sample was 40 years, range 30–53. A significant difference was found in the mean CSF activity levels of beta-hexosaminidases and beta-glucuronidase between GD1 and MLD patients. Mean ChT (CSF) was 62 nmol/h/mL in GD patients and 142 in MLD (n = 6) patients. Conclusions The patient with the highest number of NMS in our 2018 cohort was the one that developed PD, corroborating with the importance of this longitudinal follow-up. CSF and plasma analysis might allow a better understanding of the neurodegenerative processes connecting PD and the lysosomal environment. Further analysis is needed to understand this relationship.

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Section: Discussionmentioning

confidence: 99%

Follow-up of pre-motor symptoms of Parkinson’s disease in adult patients with Gaucher disease type 1 and analysis of their lysosomal enzyme profiles in the CSF

Wilke,

Poswar,

Borelli

et al. 2023

Orphanet J Rare Dis

View full text Add to dashboard Cite

show abstract

“…It was intriguing to observe that ESS signi cantly improved, and the BDI score was not worsened during the follow-up, which happened during the SARS-CoV-2 pandemic, as these were described as common during this period [25,26]. We hypothesize that the changes in habits during the pandemic, mainly working habits (including less time spent in commute due to working from home), might be responsible for these ndings.…”

Section: Discussionmentioning

confidence: 91%

Follow up of Pre-motor Symptoms of Parkinson Disease In Adult Patients With Gaucher Disease Type I and Analysis of Their Lysosomal Enzyme Profiles in Cerebrospinal Fluid

Wilke

Poswar

Borelli

et al. 2023

Preprint

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Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Its classic motor symptoms may be preceded by non-motor symptoms (NMS). Population studies have identified GBA variants as risk factors for idiopathic PD. The increased risk of PD has also been suggested in other Lysosomal Storage Disorders (LSDs). Objective To assess the evolution of the prevalence of NMS compatible with PD in a cohort of South Brazilian adult patients with Gaucher Disease (GD) type 1, already evaluated 3 years ago. Cerebrospinal Fluid (CSF) was collected to assess the levels of LSD enzymes (hexosaminidase, beta-glucuronidase) and biomarker of macrophage activation (chitotriosidase, ChT), compared to controls (metachromatic leukodystrophy, MLD). Cognition was evaluated by the MoCa questionnaire, daytime sleepiness by the Epworth Scale (ESS), depression by Beck´s Inventory, constipation by the UMSARS scale, and REM sleep behavior disorder by the single-question screen. Hyposmia was assessed with Sniffin’ Sticks (SST). Results Nineteen patients completed the follow up (mean age of the sample was 44 years; range, 26–71). The patient with the highest number of NMS at the baseline (4 including the lowest SST score) was diagnosed with PD four years later. Apart from an improvement in the ESS score, no other statistical significance was found between the number of NMS between the first and second evaluation, nor between patients with one L444P variant (n = 5) and the rest of the cohort. CSF was collected in five patients (mean age of the sample was 40 years, range 30–53. Significant difference was found between mean CSF activity of total hexosaminidase and beta glucuronidase between GD1 and MLD patients. Mean ChT (CSF) was 62 nmol/h/mL in GD patients and 142 in MLD (n = 7) patients. Conclusions The patient with the highest number of NMS in our 2018 cohort was the one that developed PD, corroborating with the importance of this longitudinal follow-up. CSF and plasma analysis might allow a better understanding of the neurodegenerative processes connecting PD and the lysosomal environment. Further analysis is needed to understand this relationship.

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Excessive Daytime Sleepiness in Hypertensive Patients: The Role of Major Depressive Disorder

Younes,

Point,

Wacquier

et al. 2024

Diagnostics

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There is a special relationship between major depressive disorder and excessive daytime sleepiness. However, given the negative impact of excessive daytime sleepiness on life quality and cardiovascular outcome in hypertensive patients, the objective of this study was to investigate the potential role played by major depressive disorder in the occurrence of this complaint for this particular subpopulation. Data from 1404 hypertensive patients recruited from the Sleep Unit’s polysomnographic recordings database were analyzed. A score >10 on the Epworth Sleepiness Scale was used to define excessive daytime sleepiness in this study. Logistic regression analyses were performed to investigate the risk of excessive daytime sleepiness associated with major depressive disorder in hypertensive patients. Excessive daytime sleepiness was frequent (40.0%) in our sample of hypertensive patients. After adjustments for major confounding factors, multivariate logistic regression analyses demonstrated that unlike remitted major depressive disorder, only current major depressive disorder was associated with a higher risk of excessive daytime sleepiness in hypertensive patients. Given this potential implication of current major depressive disorder in the occurrence of excessive daytime sleepiness for hypertensive patients, it is therefore essential to achieve the complete remission of this psychiatric disorder to avoid negative consequences associated with this complaint in this particular subpopulation.

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Sleep quality, latency, and sleepiness are positively correlated with depression symptoms of Brazilians facing the pandemic-associated stressors of COVID-19

Cited by 5 publications

References 32 publications

Follow-up of pre-motor symptoms of Parkinson’s disease in adult patients with Gaucher disease type 1 and analysis of their lysosomal enzyme profiles in the CSF

Follow-up of pre-motor symptoms of Parkinson’s disease in adult patients with Gaucher disease type 1 and analysis of their lysosomal enzyme profiles in the CSF

Follow up of Pre-motor Symptoms of Parkinson Disease In Adult Patients With Gaucher Disease Type I and Analysis of Their Lysosomal Enzyme Profiles in Cerebrospinal Fluid

Excessive Daytime Sleepiness in Hypertensive Patients: The Role of Major Depressive Disorder

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