Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults

Kaur, Sonya; Banerjee, Nikhil; Miranda, Michelle; Slugh, Mitchell; Suslow, Ni Sun; McInerney, Katalina; Sun, Xiaoyan; Ramos, Alberto R.; Rundek, Tatjana; Sacco, Ralph L.; Levin, Bonnie

doi:10.1017/s1041610220000150

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…It was supposed that individuals with a heavy burden of CSVD are more likely to have sleep disorders that subsequently lead to frailty through chronic inflammation, dysregulation of hormones, and other pathways ( Balomenos et al, 2021 ). Targeted interventions toward sleep problems (e.g., medication, cognitive behavioral therapy, sleep hygiene education) ( Kaur et al, 2020 ) could play a positive role in the prevention and treatment of frailty, thus reducing the incidence of adverse events.…”

Section: Discussionmentioning

confidence: 99%

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Zhao

Zhou

et al. 2021

Front. Aging Neurosci.

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Background: Physical frailty is a common problem among older adults which usually leads to adverse health outcomes. The imaging markers of cerebral small vessel disease (CSVD) are associated with frailty, but the underlying mechanisms remain unclear. The present study aimed to investigate the mediating role of sleep quality in the relationship between CSVD burden and frailty.Methods: We performed a cross-sectional study and enrolled community residents. Frailty and sleep quality were measured using the Fried frailty phenotype and the Pittsburgh Sleep Quality Index (PSQI), respectively. A multivariate linear regression analysis and a Bootstrap analysis were performed to examine the association among the key variables and the mediating role of sleep quality.Results: Of the 726 participants (mean age: 65.5 ± 6.5 years, 59.8% female), the numbers (percentages) of the frail, prefrail, and robust residents were 49 (6.7%), 310 (42.7%), and 367 (50.6%), respectively. After adjusting for covariates, the CSVD burden and PSQI score were significantly associated with the frailty score. In addition, sleep quality played a partial mediating role in the association between CSVD burden and physical frailty. The mediating effect was 21.9%.Conclusion: The present study suggests that sleep quality is a mediator of this association between CSVD and frailty in community-dwelling older adults. Improving sleep quality might be helpful to mitigate the risk of frailty in CSVD patients.

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Section: Discussionmentioning

confidence: 99%

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Zhao

Zhou

et al. 2021

Front. Aging Neurosci.

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“…Kaur et al [19] reported that the degree of frailty is associated with cognitive decline, and sleep quality has a mediating effect on this relationship. In that study, more-severe frailty was significantly associated with poor sleep quality.…”

Section: Relationship Between Frailty and Sleepmentioning

confidence: 99%

Frailty and Insomnia in Older Adults

2022

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Frailty is a geriatric syndrome with increased risk for poor health outcomes, including falls, cognitive impairment, hospitalization, and mortality. In previous studies, associations between frailty and sleep-related factors or sleep disorders have been investigated. We examined the relationship between frailty and insomnia, which are both common condition in older adults. Hormonal changes with aging and/or lifestyle changes all affect sleep physiology, which are vulnerable to the risk of insomnia. As the severity of frailty decreases the quality of sleep, and the long/short sleep duration is related to the risk of frailty, it can be assumed that frailty and sleep are reciprocally related. The association between frailty and insomnia has been variously proven in epidemiological studies conducted around the world. A close evaluation of insomnia and frailty in older adults provides a basis for improving the health of people in the aged society. There are few related studies in Korea, and in the future, not only basic epidemiological studies but also studies explaining the psychoneuroendocrinological mechanism of the relationship between insomnia and frailty should be performed together.

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Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults

Cui,

Meng,

et al. 2023

BMC Geriatr

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Background Little is known about the association of longitudinal dynamics between cognitive function and frailty in Chinese older adults. The temporal sequences between cognitive function and frailty remains unclear. Our study investigates this directionality association using longitudinal data. Methods Latent growth and multivariate latent growth models were employed to examine dynamics of cognition and frailty and their association among 2824 older adults in China. Cross-lagged panel analyses were used to assess the temporal sequences between frailty and cognition. The relation between cognitive domains and frailty was also examined using aforementioned methods. Results Cognitive function was negatively associated with frailty status. Higher initial level of cognition indicated lower baseline level (β=-0.175, P < 0.001) and change rate (β=-0.041, P = 0.002) of frailty. We observed a reciprocal association between frailty and cognitive function rather than a unidirectional causal relationship. The initial cognitive performance for all components were negatively associated with baseline (β ranged between − 0.098 to -0.023) and change rate (β ranged between − 0.007 to -0.024) of frail status. No consistent associations between change rate of cognitive components and either initial level or change rate of frailty were detected. Conclusions Our study detected a reciprocal association between cognition and frailty rather than a unidirectional causal relationship. Our results also revealed different connections between cognitive performance and frailty across diverse cognitive domains.

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Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults

Cited by 4 publications

References 2 publications

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Frailty and Insomnia in Older Adults

Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults

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