Sleep Quality Predicts Functional Disability in Older Adults with Low Back Pain: A Longitudinal Study

Oliveira, Sabrina Dias; Pinto, Rafael Zambelli; Gobbi, Cynthia; Fernandes, G. L.; Dokkedal‐Silva, Vinícius; Lemes, Ítalo Ribeiro; Andersen, Mônica Levy; Tufik, Sérgio; Lorençoni, Roselene Modolo Regueiro; Morelhão, Priscila K.

doi:10.1177/07334648221113500

Cited by 7 publications

(3 citation statements)

References 47 publications

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“…Many studies have reported an association between pain/function and sleep parameters, 9 10 but little is known about how OA, particularly knee pain, can affect sleep. Given these findings discussed above, we hypothesized that OA knee pain would be associated with poor sleep quality, increased daytime sleepiness, and symptoms of depression.…”

Section: Introductionmentioning

confidence: 99%

Are Sleep Quality, Daytime Sleepiness and Depression Associated with Knee Pain? A Cross-Sectional Study in Older Adults

Kakazu,

Pinto,

Dokkedal-Silva

et al. 2024

Sleep Sci

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Introduction Osteoarthritis (OA) is common among older adults, and studies have suggested that it is commonly associated with sleep problems and depression. However, the results are inconsistent concerning overall sleep quality, daytime sleepiness, and depression in studies that consider OA knee pain specifically. Objectives To examine the relationship between sleep quality, daytime sleepiness and depression, and OA knee pain in older adults. Methods This was a cross-sectional study. Adults aged 60 and above with OA knee pain according to the National Institute for Health and Care Excellence (NICE) guidelines, and who had preserved cognitive function were recruited. Sleep quality, daytime sleepiness, and depression symptoms were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and the Center for Epidemiologic Studies Depression Scale (CESD), respectively. The generalized linear model (GzLM) approach was used in the statistical analysis. A logistic regression model was performed to evaluate whether ESS, PSQI, and CESD symptoms were associated with knee pain. Results The sample comprised 451 older adults. Sleep quality (OR = 1.22, 95% confidence interval [CI]: 1.07 to 1.40) and depressive symptoms (OR = 1.09, 95%CI: 1.01 to 1.17) were associated with knee pain, but there was no association with excessive daytime sleepiness (OR= 1.09, 95%CI: 0.90 to 1.20). Conclusions Sleep quality and depression symptoms are associated with knee pain.

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Section: Introductionmentioning

confidence: 99%

Are Sleep Quality, Daytime Sleepiness and Depression Associated with Knee Pain? A Cross-Sectional Study in Older Adults

Kakazu,

Pinto,

Dokkedal-Silva

et al. 2024

Sleep Sci

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“…3 4 There are some age-related physiological changes that can affect sleep without directly compromising physical, cognitive, and functional abilities 5 . However, sleep complaints are commonly accompanied by impairments in the performance of daytime activities 6 promoting, for example, fatigue, 7 daytime sleepiness, 8 musculoskeletal pain 9 10 and even a decrease in physical activity (PA). 8 There are several age-related factors that can affect sleep, 11 but there are also a range of factors not related to age that can influence sleep quality, such as alcohol 12 13 and tobacco consumption 14 15 .…”

Section: Introductionmentioning

confidence: 99%

Physical Activity Level and Sleep Quality in Community-Dwelling Older Adults. A Cross-Sectional Study

Luciano,

Pinto,

Gobbi

et al. 2024

Sleep Sci

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The worldwide increase in life expectancy has resulted in a significant aging of the population. The physiological and functional changes that result from the aging process, changes in sleep patterns, and the prevalence of chronic diseases affect the health and well-being of individuals aged over 60. Objective The aim of this study was to investigate the relationship between levels of physical activity (PA) and sleep quality in community-dwelling older adults. Methods This is a cross-sectional study, with the participants randomly recruited according to the region and street in which they live. The Pittsburgh Sleep Quality Index (PSQI) was applied to assess sleep quality, the Modified Baecke Questionnaire for the Elderly (MBQ-E) to assess PA levels, as well as questionnaires to obtain social, demographic and anthropometric data. Multivariable regression analyses were conducted with PA activity as the independent variable and sleep quality as the dependent variable of interest, while also considering all potential covariates. Results A total of 503 older adults were analyzed, of whom 377 (75%) were classified as inactive and only 126 (25%) as active. Among the participants, 344 (68.4%) had poor sleep quality, 86 (17.1%) had symptoms of insomnia, and 57 (11.5%) reported complaints of excessive daytime sleepiness. We found that 128 participants (25.4%) consumed alcohol and 41 (8.2%) were current smokers. Multivariate regression results showed an inverse association between PA levels and sleep (Beta coefficient = −0.67 ([95% confidence interval = −1.29 to −0.04]). Conclusions The results of the study indicate that being physically inactive is associated with poor sleep quality.

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“…Daytime sleepiness, defined by having trouble staying awake during the day, is also associated with the increasing frequency of back pain ( Gustafsson et al, 2018 ). Although many observational studies have revealed a bidirectional relationship between sleep disturbances and LBP, the causal association are unclear due to the confounders ( Kelly et al, 2011 ; Goforth et al, 2014 ; Uhlig et al, 2018 ; Ho et al, 2019 ; Bilterys et al, 2021 ; Oliveira et al, 2022 ). A recent review focused on the association between sleep and spinal pain (including LBP) showed weak to moderate evidence of causality ( Van Looveren et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis

Shu

Ping

et al. 2022

Front. Genet.

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Purpose: Observational research has indicated the presence of a causal relationship between sleep disturbances and low back pain (LBP). However, the link may have been biased by confounding factors. The purpose of this study was to examine the potential causal association of insomnia and daytime sleepiness with LBP by using mendelian randomization (MR).Methods: Genome-wide association study (GWAS) summary statistics of insomnia were obtained from a large-scale GWAS meta-analysis (n = 1,331,010; individuals from UK Biobank and 23andMe) or UK Biobank alone (n = 453,379). The summary statistics of daytime sleepiness were from UK Biobank (n = 452,071) and LBP were provided by the FinnGen Release 6 (210,645 individuals with 16,356 LBP cases and 194,289 controls) or UK Biobank (5,423 cases versus 355,771 controls). Linkage disequilibrium score (LDSC) regression and bidirectional MR analysis was employed to estimate genetic correlation and causal relationship. In the MR analysis, the inverse variance weighted method (IVW) was utilized as the main analysis procedure, while MR-Egger, Weighted median and Robust adjusted profile score (RAPS) were utilized for supplementary analyses.Results: LDSC analysis showed that LBP were significantly genetically correlated with insomnia (rg = 0.57, p = 2.26e-25) and daytime sleepiness (rg = 0.18, p = 0.001). The MR analysis revealed that genetically predicted insomnia was significantly associated with an increased risk of LBP (OR = 1.250, 95% CI: 1.186–1.318; p = 1.69e-16). However, the reverse causality was not confirmed. No evidence was identified supporting causality of daytime sleepiness and LBP.Conclusion: This study demonstrates a putative causal link of insomnia on LBP and a null causal effect of LBP on insomnia. Furthermore, a causal link between daytime sleepiness and LBP were not reported. This finding may stimulate new strategies for patient management in clinical practice, benefiting public health.

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Sleep Quality Predicts Functional Disability in Older Adults with Low Back Pain: A Longitudinal Study

Cited by 7 publications

References 47 publications

Are Sleep Quality, Daytime Sleepiness and Depression Associated with Knee Pain? A Cross-Sectional Study in Older Adults

Are Sleep Quality, Daytime Sleepiness and Depression Associated with Knee Pain? A Cross-Sectional Study in Older Adults

Physical Activity Level and Sleep Quality in Community-Dwelling Older Adults. A Cross-Sectional Study

Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis

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