Sleep restriction alters cortical inhibition in migraine: A transcranial magnetic stimulation study

Mykland, Martin Syvertsen; Uglem, Martin; Neverdahl, Jan Petter; Øie, Lise Rystad; Meisingset, Tore Wergeland; Dodick, David W.; Tronvik, Erling; Engstrøm, Morten; Sand, Trond; Omland, Petter Moe

doi:10.1016/j.clinph.2022.04.004

Cited by 10 publications

(12 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neurophysiological characteristics are thought to be similar in MA and MwoA. We observed some indications of different effects of sleep restriction on GABAergic systems between these subgroups in a previous study, but the pattern of effects was not definite (18). The findings in the present study do not support that insufficient sleep affect sensorimotor processing differently in MwoA and MA.…”

Section: Discussioncontrasting

confidence: 94%

“…Consequently, an underlying GABAergic dysfunction causing disturbed sleep may be involved in SM, becoming further dysregulated with sleep restriction. However, possible GABA-B mediated effects in SM is likely different from the altered function of dopamine regulated GABA-B inhibitory duration we previously observed after sleep restriction in NSM, but not in SM (18). Furthermore, preventive medication increasing GABA levels such as valproate and gabapentin, are used in migraineurs with varying effect (39).…”

Section: Discussionmentioning

confidence: 75%

See 1 more Smart Citation

Effects of insufficient sleep on sensorimotor processing in migraine: A randomised, blinded crossover study of event related beta oscillations

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Migraine has a largely unexplained connection with sleep and is possibly related to a dysfunction of thalamocortical systems and cortical inhibition. In this study we investigate the effect of insufficient sleep on cortical sensorimotor processing in migraine. Methods We recorded electroencephalography during a sensorimotor task from 46 interictal migraineurs and 28 controls after two nights of eight-hour habitual sleep and after two nights of four-hour restricted sleep. We compared changes in beta oscillations of the sensorimotor cortex after the two sleep conditions between migraineurs, controls and subgroups differentiating migraine subjects usually having attacks starting during sleep and not during sleep. We included preictal and postictal recordings in a secondary analysis of temporal changes in relation to attacks. Results Interictally, we discovered lower beta synchronisation after sleep restriction in sleep related migraine compared to non-sleep related migraine (p=0.006) and controls (p=0.01). No differences were seen between controls and the total migraine group in the interictal phase. After migraine attacks, we observed lower beta synchronisation (p<0.001) and higher beta desynchronisation (p=0.002) after sleep restriction closer to the end of the attack compared to later after the attack. Conclusion The subgroup with sleep related migraine had lower sensorimotor beta synchronisation after sleep restriction, possibly related to dysfunctional GABAergic inhibitory systems. Sufficient sleep during or immediately after migraine attacks may be of importance for maintaining normal cortical excitability.

show abstract

Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 75%

Effects of insufficient sleep on sensorimotor processing in migraine: A randomised, blinded crossover study of event related beta oscillations

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…We included CSP duration and every ppTMS and SAI peak-to-peak amplitude in separate linear mixed models for each of the different TMS-responses. Linear mixed models are well suited to handle missing data for when subjects had recordings of different sleep conditions in different phases and is commonly applied for repeated measurements (20,27). Every analysis was performed with an intention to treat basis with intended sleep as sleep condition.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, a total of 54 migraine patients (Table 1) were examined. We have previously reported data from the interictal phase compared to controls from the same study (20).…”

Section: Subjectsmentioning

confidence: 99%

“…Sleep restriction as an experimental model of insufficient sleep has previously been shown to affect cortical responses in healthy volunteers (19) and we have recently shown that sleep restriction alters GABAergic inhibition in interictal migraine patients compared to controls (20). Thus, sleep restriction may amplify differences in neurological functioning which are usually subtle or compensated, allowing us to measure dynamics of migraine mechanisms which are specific to parts of the migraine cycle and reactive to sleep changes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Insufficient sleep may alter cortical excitability near the migraine attack: A blinded TMS crossover study

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Migraine is a brain disorder with a multifaceted and unexplained association to sleep. Brain excitability likely changes periodically throughout the migraine cycle. In this study we examine the effect of insufficient sleep on neuronal excitability during the course of the migraine cycle. Methods We examined 54 migraine patients after two nights of eight-hour habitual sleep and two nights of four-hour restricted sleep in a randomised, blinded crossover study. We performed transcranial magnetic stimulation and measured cortical silent period, short- and long-interval intracortical inhibition, intracortical facilitation and short-latency afferent inhibition. We analysed how responses changed before and after attacks with linear mixed models. Results Short- interval intracortical inhibition was more reduced after sleep restriction compared to habitual sleep the shorter the time that had elapsed since the attack ( p = 0.041), and specifically in the postictal phase ( p = 0.013). Long-interval intracortical inhibition was more increased after sleep restriction with time closer before the attack ( p = 0.006), and specifically in the preictal phase ( p = 0.034). Short-latency afferent inhibition was more decreased after sleep restriction with time closer to the start of the attack ( p = 0.026). Conclusion Insufficient sleep in the period leading up to a migraine attack may cause dysfunction in cortical GABAergic inhibition. The results also suggest that migraine patients may have increased need for sufficient sleep during a migraine attack to maintain normal neurological function after the attack.

show abstract

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee

Vucic¹,

Chen²,

Kiernan³

et al. 2023

Clinical Neurophysiology

View full text Add to dashboard Cite

Sleep restriction alters cortical inhibition in migraine: A transcranial magnetic stimulation study

Cited by 10 publications

References 114 publications

Effects of insufficient sleep on sensorimotor processing in migraine: A randomised, blinded crossover study of event related beta oscillations

Effects of insufficient sleep on sensorimotor processing in migraine: A randomised, blinded crossover study of event related beta oscillations

Insufficient sleep may alter cortical excitability near the migraine attack: A blinded TMS crossover study

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee

Contact Info

Product

Resources

About