Sleep restriction in rats leads to changes in operant behaviour indicative of reduced prefrontal cortex function

Kamphuis, Jeanine; Baichel, S.; Lancel, Marike; Boer, Sietse F. de; Koolhaas, Jaap M.; Meerlo, Peter

doi:10.1111/jsr.12455

Cited by 12 publications

(5 citation statements)

References 34 publications

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“…We also assessed emotional (i.e., anxiety) and motivational (i.e., reward) functions. In our experimental condition, HAB or PSD alone caused opposite impulsivity and anxiety effects, as has been observed in previous studies 13,25,26. This could indicate that HAB functioned as an anxiogenic stimulus, since there was an almost complete lack of central zone entries at the long-term evaluation point.…”

Section: Discussionsupporting

confidence: 83%

Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats

Rabelo‐da‐Ponte

Gomes

Torres

et al. 2019

Braz. J. Psychiatry

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Objective:To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned).Methods:We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever with a fixed interval of 1 minute and a limited hold of 3 seconds. On the last day of phase I, an open-field test was performed and the animals were divided into four experimental groups (n=8/group). In phase II (repeated stress), each group was exposed to either hot air blast (HAB), paradoxical sleep deprivation (PSD) or both (HAB+PSD group) on alternate days over a 10-day period. Control group animals were not exposed to stressors. In phase III (post-stress evaluation), behavior was analyzed on the first (short-term effects), third (mid-term effects), and fifth (long-term effects) days after repeated stress.Results:The PSD group presented operant hyperactivity, the HAB group presented spontaneous hypoactivity and anxiety, and the HAB+PSD group presented spontaneous hyperactivity, operant hypoactivity, impulsivity, loss of interest, and cognitive impairment.Conclusion:A combination of environmental stressors (HAB and PSD) may induce endophenotypes related to bipolar disorder.

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Section: Discussionsupporting

confidence: 83%

Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats

Rabelo‐da‐Ponte

Gomes

Torres

et al. 2019

Braz. J. Psychiatry

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“…Another study using water restriction found significant but less pronounced effects on time-on-task PVT-like measures than would be expected using food reward [24]. Not all studies find that food-restricted animals are more resilient to SR [12,36], which may critically depend on the performance demands of the task employed. All goal-directed behavioral tasks engage motivational and attentional processes, and while SRLT tasks are most often interpreted in the context of attentional function, performance deficits may also be due to decreases in motivation to respond.…”

Section: Discussionmentioning

confidence: 99%

Food restriction induces functional resilience to sleep restriction in rats

Loomis

McCarthy

Dijk

et al. 2020

Sleep

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Study Objectives Sleep restriction (SR) leads to performance decrements across cognitive domains but underlying mechanisms remain largely unknown. The impact of SR on performance in rodents is often assessed using tasks in which food is the reward. Investigating how the drives of hunger and sleep interact to modulate performance may provide insights into mechanisms underlying sleep loss-related performance decrements. Methods Three experiments were conducted in male adult Wistar rats to assess: (1) effects of food restriction on performance in the simple response latency task (SRLT) across the diurnal cycle (n = 30); (2) interaction of food restriction and SR (11 h) on SRLT performance, sleep electroencephalogram, and event-related potentials (ERP) (n = 10–13); and (3) effects of food restriction and SR on progressive ratio (PR) task performance to probe the reward value of food reinforcement (n = 19). Results Food restriction increased premature responding on the SRLT at the end of the light period of the diurnal cycle. SR led to marked impairments in SRLT performance in the ad libitum-fed group, which were absent in the food-restricted group. After SR, food-restricted rats displayed a higher amplitude of cue-evoked ERP components during the SRLT compared with the ad libitum group. SR did not affect PR performance, while food restriction improved performance. Conclusions Hunger may induce a functional resilience to negative effects of sleep loss during subsequent task performance, possibly by maintaining attention to food-related cues.

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“…If waking SPW-Rs were sufficient for consolidation an increased duration of waking, i.e., sleep restriction, should improve memory performance, the opposite of which is observed (Kamphuis et al, 2017);…”

Section: Nrems Oscillations and Memory Consolidationmentioning

confidence: 99%

Remembering to Forget: A Dual Role for Sleep Oscillations in Memory Consolidation and Forgetting

Langille

2019

Front. Cell. Neurosci.

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It has been known since the time of patient H. M. and Karl Lashley’s equipotentiality studies that the hippocampus and cortex serve mnestic functions. Current memory models maintain that these two brain structures accomplish unique, but interactive, memory functions. Specifically, most modeling suggests that memories are rapidly acquired during waking experience by the hippocampus, before being later consolidated into the cortex for long-term storage. Sleep has been shown to be critical for the transfer and consolidation of memories in the cortex. Like memory consolidation, a role for sleep in adaptive forgetting has both historical precedent, as Francis Crick suggested in 1983 that sleep was for “reverse-learning,” and recent empirical support. In this article I review the evidence indicating that the same brain activity involved in sleep replay associated memory consolidation is responsible for sleep-dependent forgetting. In reviewing the literature, it became clear that both a cellular mechanism for systems consolidation and an agreed upon general, as well as cellular, mechanism for sleep-dependent forgetting is seldom discussed or is lacking. I advocate here for a candidate cellular systems consolidation mechanism wherein changes in calcium kinetics and the activation of consolidative signaling cascades arise from the triple phase locking of non-rapid eye movement sleep (NREMS) slow oscillation, sleep spindle and sharp-wave ripple rhythms. I go on to speculatively consider several sleep stage specific forgetting mechanisms and conclude by discussing a notional function of NREM-rapid eye movement sleep (REMS) cycling. The discussed model argues that the cyclical organization of sleep functions to first lay down and edit and then stabilize and integrate engrams. All things considered, it is increasingly clear that hallmark sleep stage rhythms, including several NREMS oscillations and the REMS hippocampal theta rhythm, serve the dual function of enabling simultaneous memory consolidation and adaptive forgetting. Specifically, the same sleep rhythms that consolidate new memories, in the cortex and hippocampus, simultaneously organize the adaptive forgetting of older memories in these brain regions.

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Sleep restriction in rats leads to changes in operant behaviour indicative of reduced prefrontal cortex function

Cited by 12 publications

References 34 publications

Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats

Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats

Food restriction induces functional resilience to sleep restriction in rats

Remembering to Forget: A Dual Role for Sleep Oscillations in Memory Consolidation and Forgetting

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