Sleep spindle alterations in patients with Parkinson's disease

Christensen, J. H.; Nikolic, Miki; Warby, Simon C.; Koch, H; Zoetmulder, Marielle; Frandsen, Rune; Moghadam, Keivan Kaveh; Sørensen, Helge Bjarup Dissing; Mignot, Emmanuel; Jennum, Poul

doi:10.1016/j.sleep.2015.02.115

Cited by 6 publications

(7 citation statements)

References 54 publications

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“…In terms of sleep microstructure, sleep spindles, regarded as a hallmark of NREM 2 sleep, have been found to have lower density, longer duration, slower frequency of oscillation and higher amplitude in patients with PD compared with healthy controls in some (Christensen et al, 2015;Emser et al, 1988) but not all studies (Happe et al, 2004), and this matter is still a point for debate. In a study comparing 68 patients with PD with 47 healthy subjects, Latreille and collaborators observed sleep spindle density and slow-wave amplitude to be lower in patients with PD than in controls (Latreille et al, 2015).…”

Section: Sleep Architecturementioning

confidence: 99%

An overview of sleep and circadian dysfunction in Parkinson's disease

Mantovani

Smith

Gordon

et al. 2018

Journal of Sleep Research

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Sleep and circadian alterations are amongst the very first symptoms experienced in Parkinson's disease, and sleep alterations are present in the majority of patients with overt clinical manifestation of Parkinson's disease. However, the magnitude of sleep and circadian dysfunction in Parkinson's disease, and its influence on the pathophysiology of Parkinson's disease remains often unclear and a matter of debate. In particular, the confounding influences of dopaminergic therapy on sleep and circadian dysfunction are a major challenge, and need to be more carefully addressed in clinical studies. The scope of this narrative review is to summarise the current knowledge around both sleep and circadian alterations in Parkinson's disease. We provide an overview on the frequency of excessive daytime sleepiness, insomnia, restless legs, obstructive apnea and nocturia in Parkinson's disease, as well as addressing sleep structure, rapid eye movement sleep behaviour disorder and circadian features in Parkinson's disease. Sleep and circadian disorders have been linked to pathological conditions that are often co-morbid in Parkinson's disease, including cognitive decline, memory impairment and neurodegeneration. Therefore, targeting sleep and circadian alterations could be one of the earliest and most promising opportunities to slow disease progression. We hope that this review will contribute to advance the discussion and inform new research efforts to progress our knowledge in this field.

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Section: Sleep Architecturementioning

confidence: 99%

An overview of sleep and circadian dysfunction in Parkinson's disease

Mantovani

Smith

Gordon

et al. 2018

Journal of Sleep Research

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“…Each detected spindle was characterized by its: (1) duration; (2) oscillation frequency; (3) maximum peak-to-peak amplitude; and (4) symmetry (percent-to-peak amplitude); all of which are well evaluated and have been used elsewhere (Christensen et al, 2015;Warby et al, 2014). Before any of the measures were computed, the central EEG signal was filtered with the same filters (notch and band-pass of 0.3-35 Hz) as in the pre-processing step before the spindle detection.…”

Section: Spindle Morphology Measuresmentioning

confidence: 99%

“…Due to the detection procedure, the resolution of the spindle duration was 0.25 s. The oscillation frequency was defined in Hz and was estimated as and l max k ), and is therefore less biased by the low resolution of the duration of each spindle. The extrema points were detected in the same way as previously validated (Christensen et al, 2015) using Matlab's findpeaks-function applied on a five-point moving average smoothed version of the spindle signal and with a minimum peak-topeak distance of 11 samples. Similar to previously, the maximum points were found applying the function directly, while the minima points were found by applying the function on the flipped signal.…”

Section: Spindle Morphology Measuresmentioning

confidence: 99%

Investigation of sleep spindle activity and morphology as predictors of neurocognitive functioning in medicated patients with schizophrenia

Baandrup

Christensen

Fagerlund

et al. 2018

Journal of Sleep Research

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Neurocognitive impairment is a trait marker of schizophrenia, but no effective treatment has yet been identified. Sleep spindle deficits have been associated with diminished sleep-dependent memory learning. We examined whether this link could be extended into various cognitive domains by investigating the association of a neurocognitive test battery (the Brief Assessment of Cognition in Schizophrenia) with sleep spindle activity and morphology. We examined 37 outpatients diagnosed with schizophrenia and medicated with both antipsychotics and benzodiazepines. Participants underwent 1 night polysomnography and test of neurocognitive functioning. We identified and analysed sleep spindles in all non-rapid eye movement sleep and in non-rapid eye movement sleep stage 2 in a central electroencephalography channel using an automatic sleep spindle detector previously validated. Slow sleep spindle density was computed from a frontal electroencephalography channel as well. We found no association between cognitive functioning and sleep spindle density or sleep spindle morphology for spindles in non-rapid eye movement sleep when controlling for gender, age, symptom severity, and daily dose of antipsychotics and benzodiazepines. For spindles in non-rapid eye movement sleep stage 2, we found that motor speed was associated with frontal slow sleep spindle density. We conclude that frontal slow spindle density might predict motor speed in medicated patients with schizophrenia, but that no other sleep spindle activity or sleep spindle morphology measures were predictors of neurocognitive functioning.

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“…In patients with PD, both the sleep macrostructure (manifesting for instance as sleep fragmentation and a relative increase in superficial sleep) [23,24] and sleep microstructure, manifesting as disturbed integrity of certain sleep stages (e.g. disturbed sleep spindles and K-complexes, or insufficient muscle atonia during REM sleep) [25][26][27][28][29][30][31][32] are affected.…”

Section: Introductionmentioning

confidence: 99%

Sleep in Parkinson’s disease

Stefani

Högl

2019

Neuropsychopharmacol.

177

104

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Sleep disturbances are common in Parkinson's disease and comprise the entire spectrum of sleep disorders. On the one hand regulation of sleep and wakefulness is affected in Parkinson's disease, leading to the development of disorders, such as insomnia and daytime sleepiness. While on the other hand control of motor activity during sleep is impaired, with subsequent manifestation of parasomnias (mainly REM sleep behavior disorders, but also, albeit more rarely, sleepwalking, and overlap parasomnia). Restless legs syndrome has been reported to be frequent in patients with Parkinson's disease, although there is no consensus on whether it is more frequent in Parkinson's disease than in the general population. The same is true for sleep-related breathing disorders. Regarding the diagnosis of sleep disorders in patients with Parkinson's disease, one of the main challenges is correctly identifying excessive daytime sleepiness as there are many potential confounding factors, for example it is necessary to distinguish sleeprelated breathing disorders from medication effects, and to distinguish restless legs syndrome from the concomitant presence of potential mimics specific to Parkinson's disease, such as akathisia, nocturnal leg cramps, nocturnal hypokinesia, early morning dystonia, etc. The correct diagnosis of REM sleep behavior disorder is also not always easy, and video-polysomnography should be performed in order to exclude mimic-like movements at the end of sleep apneas or violent periodic leg movements of sleep. These aspects and specific considerations about diagnosis and treatment of sleep disorders in patients with Parkinson's disease will be reviewed.

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Sleep spindle alterations in patients with Parkinson's disease

Cited by 6 publications

References 54 publications

An overview of sleep and circadian dysfunction in Parkinson's disease

An overview of sleep and circadian dysfunction in Parkinson's disease

Investigation of sleep spindle activity and morphology as predictors of neurocognitive functioning in medicated patients with schizophrenia

Sleep in Parkinson’s disease

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