Sleep Spindles – As a Biomarker of Brain Function and Plasticity

Urakami, Yuko; Ioannides, Andreas A.; Kostopoulos, George

doi:10.5772/48427

Cited by 30 publications

(45 citation statements)

References 150 publications

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“…In two studies, CSF tau protein dosage was significantly higher in CBDS than in PSP and in healthy controls [54,57], whereas two other studies showed no significant differences among groups [37,56]. Moreover, it has to be acknowledged that in these studies no additional comparison groups of patients affected by other extrapyramidal syndrome and dementias were included.…”

Section: Biological Markers For the Diagnosis Of Progressive Supranucmentioning

confidence: 92%

“…Literature data have demonstrated that CSF tau levels were found within normal range in PSP, whilst results in CBDS are contradictory [33,[54][55][56][57][58]. In two studies, CSF tau protein dosage was significantly higher in CBDS than in PSP and in healthy controls [54,57], whereas two other studies showed no significant differences among groups [37,56].…”

Section: Biological Markers For the Diagnosis Of Progressive Supranucmentioning

confidence: 92%

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New Insights into Biological Markers of Frontotemporal Lobar Degeneration Spectrum

Borroni¹,

Alberici²,

Archetti³

et al. 2010

CMC

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In the last decade, there has been enormous progress in our understanding of Frontotemporal Lobar Degeneration (FTLD). Published clinicopathological series have clearly demonstrated an overlap between the clinical syndromes subsumed under the term frontotemporal dementia and the Progressive Supranuclear Palsy (PSP), and the Corticobasal Degeneration (CBD) syndrome. From a neuropathological point of view, two broad pathological subdivisions of FTLD are currently recognized: a) tau-positive pathology due to the accumulation of various forms of the microtubule-associated protein tau, that encompasses FTLD with Pick bodies, PSP and CBD, and b) tau-negative pathology, mainly characterized by ubiquitin/TDP-43-immunoreactive inclusions and in some cases due to Progranulin mutations. Several biological markers in cerebrospinal fluid and in blood have been evaluated to identify monogenic forms of FTLD and to differentiate either FTLD spectrum disorders or FTLD from other neurodegenerative disorders. The proposed biomarkers are primarily related to the mechanisms underlying the accumulation of the abnormal proteins in FTLD such as Tau, TDP-43 and Progranulin. These biomarkers may support the accurate diagnosis of the specific diseases causing FTLD, can be useful in assessing efficacy during pharmacological trials, and may help in identifying new molecular targets for treatment approaches. In this review, we summarise the most recent findings on biological markers and their usefulness in clinical practice for the diagnosis and management of FTLD.

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Section: Biological Markers For the Diagnosis Of Progressive Supranucmentioning

confidence: 92%

Section: Biological Markers For the Diagnosis Of Progressive Supranucmentioning

confidence: 92%

New Insights into Biological Markers of Frontotemporal Lobar Degeneration Spectrum

Borroni¹,

Alberici²,

Archetti³

et al. 2010

CMC

View full text Add to dashboard Cite

show abstract

“…Medial components of the posterior intralaminar region of the central thalamus are involved in spindle generation. Therefore, the recovery of consciousness may be strongly associated with the recovery of sleep spindles after brain injury [30,31]. In patients who have TBI, findings of sleep architecture are inconsistent and may include; no changes, increased slow waves, decreased rapid eye movement sleep, increased rapid eye movement sleep during the second half of the night, no change in rapid eye movement sleep, or decreased onset latency of rapid eye movement sleep.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiologic Evaluation of Diffuse Axonal Injury after Traumatic Brain Injury

Urakami¹

2013

J Neurol Neurophysiol

Self Cite

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“…Sleep spindles are one of the basic thalamo-cortical EEG oscillations that classically contribute to sleep promotion and maintenance, and are associated to sensory gating, motor representation development, cognition, and memory consolidation [70]. Spindle frequency is basically determined by the interplay of GABAergic inhibitory neurons of the RT nucleus and the TC neurons, their intrinsic properties, and their influence by cortical descending and the brainstem ascending inputs.…”

Section: Transl Brainmentioning

confidence: 99%

“…Spindle frequency is basically determined by the interplay of GABAergic inhibitory neurons of the RT nucleus and the TC neurons, their intrinsic properties, and their influence by cortical descending and the brainstem ascending inputs. The duration of IPSPs imposed by RT neurons on TC neurons determines the intra-spindle frequency [70].…”

Section: Transl Brainmentioning

confidence: 99%

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

Ciric¹,

Lazic²,

Petrović³

et al. 2017

Transl Brain Rhythmicity

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Rhythmic oscillations of neuronal populations, generated by different mechanisms, are present at several levels of the central nervous system and serve many important physiological or reflect pathological functions. Understanding the role of brain oscillations as possible biomarkers of brain function and plasticity is still a challenge, and despite extensive research, their role is still not well established.We recently demonstrated that the hallmarks of earlier aging onset during impaired thalamo-cortical cholinergic innervation (in a rat model of Parkinson's disease cholinopathy) were consistently expressed, from 3 and one half to 5 and one half months of age, through increased electroencephalographic (EEG) sigma activity amplitude during rapid eye movement (REM) sleep, as a unique aging induced REM sleep phenomenon. In addition, there was altered motor cortical drive during non-rapid-eye-movement (NREM) and REM sleep.In order to explain this new aging-induced REM sleep phenomenon, we analyzed possible differences between control REM sleep spindle activity and REM sleep spindle activity at the onset of REM sleep "enriched" with sigma activity (at 4 and one half months of age), following bilateral pedunculopontine tegmental nucleus (PPT) cholinergic neuronal loss in the rat. We analzyed differences in spindle density, duration, and frequency.We demonstrated in young adult Wistar rats with the severely impaired PPT cholinergic innervation the alterations in sleep spindle dynamics and pattern during REM sleep in the motor cortex as the earliest biomarkers for the onset of their altered aging processes.

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Sleep Spindles – As a Biomarker of Brain Function and Plasticity

Cited by 30 publications

References 150 publications

New Insights into Biological Markers of Frontotemporal Lobar Degeneration Spectrum

New Insights into Biological Markers of Frontotemporal Lobar Degeneration Spectrum

Electrophysiologic Evaluation of Diffuse Axonal Injury after Traumatic Brain Injury

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

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