Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson's disease

Christensen, J. H.; Koch, H; Frandsen, Rune; Zoetmulder, Marielle; Arvastson, Lars; Christensen, Søren Rahn; Sørensen, Henrik Rokkjær; Jennum, Poul

doi:10.1016/j.sleep.2015.02.1422

Cited by 8 publications

(14 citation statements)

References 26 publications

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“…29 The absence of sleep medication, such as clonazepam may have resulted higher rates of sleep disturbance in our patients than the previous reported results. The sleep fragmentation observed in IRBD may therefore be caused by unstable wake/sleep and REM/NREM transitions, 30 in line with the findings of a previous study. 29 Phobic anxiety was the most prominent neuropsychiatric symptom observed in IRBD, followed by interpersonal sensitivity.…”

Section: Discussionsupporting

confidence: 92%

Neuropsychiatric Symptoms in Patients with Idiopathic Rapid Eye Movement Sleep Behavior Disorder

et al. 2017

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Background and ObjectiveaaIdiopathic rapid eye movement sleep behavior disorder (IRBD) is a strong predictor of the development of synucleinopathies, including Parkinson's disease. Neuropsychiatric symptoms are common in patients with Parkinson's disease but have not been properly evaluated in IRBD. We used the Symptom Checklist-90-Revision (SCL-90-R) to evaluate the symptom profile of patients with drug-naïve IRBD. MethodsaaConsecutive drug-naïve patients with video-polysomnography-confirmed IRBD that visited Kyung Hee University Hospital at Gangdong sleep clinic January 2009-November 2016 were reviewed. Age-and sex-matched healthy volunteers served as controls. Questionnaires evaluating sleep [Pittsburgh sleep quality index (PSQI) and insomnia severity index (ISI)] and depression [beck depression inventory-II (BDI-II)] were conducted with the SCL-90-R in IRBD patients and controls. resultsaaTwenty patients with IRBD and 20 age-and sex-matched controls were analyzed. In IRBD patients, the mean age was 59.5, 55% were male, and the mean disease duration was 55.1 months. PSQI scores (5.7 ± 2.2 vs. 3.2 ± 1.4, p < 0.0001) and ISI scores (11.2 ± 8.7 vs. 4.1 ± 3.4, p < 0.0001) were higher in patients with IRBD than in the controls. Three IRBD patients (15%) had abnormal SCL-90-R T-scores over 70. The T-scores for phobic anxiety (p=0.009), interpersonal sensitivity (p = 0.011), psychoticism (p = 0.013), hostility (p = 0.014), anxiety (p = 0.020), and depression (p = 0.049) were higher in the patients. After adjusting for age, BDI-II scores were positively correlated with RBD disease duration (r = 0.484, p = 0.042) in IRBD patients. ConclusionsaaThe results of our study demonstrate that neuropsychiatric distress is more severe in patients with IRBD with no comorbidities than in otherwise healthy individuals.

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Section: Discussionsupporting

confidence: 92%

Neuropsychiatric Symptoms in Patients with Idiopathic Rapid Eye Movement Sleep Behavior Disorder

et al. 2017

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“…The apparently specific impact of hippocampal damage on SWS was further underlined by analyses of sleep stability and fragmentation (see Table 1 for summary data and statistical analyses; STAR Methods). Despite the reduced SWS in the patients, measures including the number of arousals/awakenings per hour of total sleep time, the number of shifts from one state to another, the number of periods of functional uncertainty [16], the number of shifts from any sleep stage to wakefulness, and the overall stability of NREM and REM sleep were not significantly different between the patients and control participants [17].…”

Section: Sleep Stability and Fragmentationmentioning

confidence: 69%

Sleeping with Hippocampal Damage

Spanò

Weber²,

Pizzamiglio

et al. 2020

Current Biology

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“…22,23 Perhaps in agreement with its altered physiological role, an altered caudate recruitment has been linked to pathologic hyperarousal, inability to initiate and maintain sleep, deficits in executive functioning, 24 and altered timing and spatial navigation in several other disorders. 23 In iRBD, however, previous studies have demonstrated decreased REM stage stability, 13 along with higher beta-band increases during REM. 11 In that background, the data in this study that link caudate dopaminergic availability and REM sleep may suggest a distinct altered caudate response in iRBD.…”

Section: Discussionmentioning

confidence: 95%

“…10 Accordingly, sleep issues in the disease process are more likely to appear first if the lesions start in the caudoventral mesopontine junction where caudate-labelled cells predominate. 10 To date, surprisingly little is still known about macroscopic and microscopic sleep structure in iRBD, 4,[11][12][13] and even less so about its relationship with dopaminergic deficit within the striatum. The aim of this exploratory study was hence to investigate the relationship between early sleep changes and striatal functionality in iRBD in terms of both the severity and topography of nigrostriatal deafferentation by means of 123 I-ioflupane-SPECT data in de novo iRBD patients, as well as in comparison with polysomnographic (PSG) data from healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Striatal Dopaminergic Deficit and Sleep in Idiopathic Rapid Eye Movement Behaviour Disorder: An Explorative Study

Wasserman¹,

Bindman²,

Nesbitt³

et al. 2021

NSS

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Introduction: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is increasingly recognised as an important precursor disease state of alpha-synucleinopathies. This parasomnia is characterized by a history of recurrent nocturnal dream enactment behaviour, loss of skeletal muscle atonia, and increased phasic muscle activity during REM sleep. Neuroimaging studies of striatal dopamine transporter uptake tracer signaling suggest increasing dopaminergic deficit across the continuum of the alpha-synucleinopathies, with early sleep dysfunction suggestive of early caudate dysfunction. Henceforth, we set out to investigate the relationship between early sleep changes and the striatal dopaminergic availability in iRBD. Methods: Twelve patients with iRBD, who had undergone a video polysomnography and a neuroimaging assessment of striatal dopamine transporter (DaT) uptake tracer signaling, and 22 matched controls who had similarly undergone a video polysomnography were retrospectively identified. Data were statistically analyzed to identify altered sleep parameters and correlate them with striatal dopamine transporter uptake tracer signaling. Results: The iRBD patients exhibited an increased number of periodic limb movements during sleep (P=0.001), compared to 22 age-matched healthy subjects. In addition, several significant links were found between regional DaT-uptakes and sleep architecture. Correlational analyses suggested a strong positive association between sleep fragmentation and dopamine deficiency in left caudate (r=−0.630, P=0.028), whilst an increased uptake in the whole striatum was strongly linked to the sleep efficiency, and to a lesser degree to the length of sleep duration. Discussion: To the best of our knowledge, this is the first demonstration of a close relationship between dopaminergic availability in striatum and the quality of sleep in iRBD. Taken together, our exploratory findings suggest that subtle but functionally significant striatal changes in early stages of iRBD may contribute to the further shaping of sleep architecture.

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Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson's disease

Cited by 8 publications

References 26 publications

Neuropsychiatric Symptoms in Patients with Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Neuropsychiatric Symptoms in Patients with Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Sleeping with Hippocampal Damage

Striatal Dopaminergic Deficit and Sleep in Idiopathic Rapid Eye Movement Behaviour Disorder: An Explorative Study

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