Sleep-Wake and Cortical Synaptic Plasticity

Timofeev, Igor; Chauvette, Sylvain

doi:10.1016/b978-0-12-813743-7.00029-3

Cited by 4 publications

(2 citation statements)

References 153 publications

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“…On the one hand, it provides a mechanism by which synaptic efficacy returns to a homeostatic set-point during sleep, restoring the ability of the network to learn new information on the next day. Such a mechanism could play a central role in sleep homeostasis [48][49][50]. On the other hand, the homeostatic reset disrupts any learning that occurred during the previous day, which could lead to catastrophic forgetting [51].…”

Section: Discussionmentioning

confidence: 99%

Switches to slow rhythmic neuronal activity lead to a plasticity-induced reset in synaptic weights

Jacquerie

Minne

Ponnet

et al. 2022

Preprint

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Brain function relies on the ability to quickly process incoming information while being capable of forming memories of past relevant events through the formation of novel synaptic connections. Synaptic connections are functionally strengthened or weakened to form new memories through synaptic plasticity rules that strongly rely on neuronal rhythmic activities. Brain information processing, on the other hand, is shaped by fluctuations in these neuronal rhythmic activities, each defining distinctive brain states, which poses the question of how such fluctuations in brain states affect the outcome of memory formation. This question is particularly relevant in the context of sleep-dependent memory consolidation, wakefulness to sleep transitions being characterized by large modifications in global neuronal activity. By combining computational models of neuronal activity switches and plasticity rules, we show that switches to rhythmic brain activity reminiscent of sleep lead to a reset in synaptic weights towards a basal value. This reset is shown to occur both in phenomenological and biophysical models of synaptic plasticity, and to be robust to neuronal and synaptic variability and network heterogeneity. Analytical analyses further show that the mechanisms of the synaptic reset are rooted in the endogenous nature of the sleep-like rhythmic activity. This sleep-dependent reset in synaptic weights permits regularizing synaptic connections during sleep, which could be a key component of sleep homeostasis and has the potential to play a central role in sleep-dependent memory consolidation.

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Section: Discussionmentioning

confidence: 99%

Switches to slow rhythmic neuronal activity lead to a plasticity-induced reset in synaptic weights

Jacquerie

Minne

Ponnet

et al. 2022

Preprint

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show abstract

“…Considering the well-established link between sleep and memory consolidation 4,27,28 , we investigated the role of the reuniens in coupling hippocampo-cortical oscillations during non-rapid eye movement (NREM) and REM sleep. Using in vivo intracellular recordings, computational modelling, and spike/local field potential (LFP) recordings, we demonstrate that reuniens is driven by hippocampal oscillations during sleep and that it elicits fast, consistent synaptic responses in mPFC.…”

Section: Introductionmentioning

confidence: 99%

The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep

Basha,

Azarmehri,

Proulx

et al. 2023

Preprint

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SummaryMemory consolidation during sleep depends on the interregional coupling of slow waves, spindles, and sharp wave-ripples (SWRs), across the cortex, thalamus, and hippocampus. The reuniens nucleus of the thalamus, linking the medial prefrontal cortex (mPFC) and the hippocampus, may facilitate interregional coupling during sleep. To test this, electrophysiological recordings were obtained in vivo from the cat reuniens nucleus, prefrontal cortex and hippocampus. Interregional synchrony was measured using phase-amplitude coupling and interregional time delays between SWRs, spindles and slow waves together with reuniens spiking and local field potential (LFP) activity. Electrical stimulation of the reuniens evoked intracellular mPFC responses, consistent with bidirectional functional connectivity between mPFC-reuniens and hippocampus. Cortical slow waves preceded reuniens slow waves and hippocampal SWRs. Hippocampal SWRs and REM sleep theta modulated reuniens activities and reuniens spindles preceded cortical spindles. The neural mass model of this network demonstrates that the strength of bidirectional hippocampo-thalamic connections determines the coupling of oscillations, suggesting a mechanistic link between synaptic weights and the propensity for interregional synchrony.Impact StatementThe nucleus reuniens of the thalamus play a central role in synchronizing the mPFC-hippocampal network during sleep and integrates converging activity from hippocampal and mPFC oscillations.

show abstract

The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep

Basha,

Azarmehri,

Proulx

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Memory consolidation during sleep depends on the interregional coupling of slow waves, spindles, and sharp wave-ripples (SWRs), across the cortex, thalamus, and hippocampus. The reuniens nucleus of the thalamus, linking the medial prefrontal cortex (mPFC) and the hippocampus, may facilitate interregional coupling during sleep. To test this, electrophysiological recordings were obtained in vivo from the cat reuniens nucleus, prefrontal cortex and hippocampus. Interregional synchrony was measured using phase-amplitude coupling and interregional time delays between SWRs, spindles and slow waves together with reuniens spiking and local field potential (LFP) activity. Electrical stimulation of the reuniens evoked intracellular mPFC responses, consistent with bidirectional functional connectivity between mPFC-reuniens and hippocampus. Cortical slow waves preceded reuniens slow waves and hippocampal SWRs. Hippocampal SWRs and REM sleep theta modulated reuniens activities and reuniens spindles preceded cortical spindles. The neural mass model of this network demonstrates that the strength of bidirectional hippocampo-thalamic connections determines the coupling of oscillations, suggesting a mechanistic link between synaptic weights and the propensity for interregional synchrony. The nucleus reuniens of the thalamus play a central role in synchronizing the mPFC-hippocampal network during sleep and integrates converging activity from hippocampal and mPFC oscillations.

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Sleep-Wake and Cortical Synaptic Plasticity

Cited by 4 publications

References 153 publications

Switches to slow rhythmic neuronal activity lead to a plasticity-induced reset in synaptic weights

Switches to slow rhythmic neuronal activity lead to a plasticity-induced reset in synaptic weights

The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep

The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep

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