Sleep-Wake Cycle in Human African Trypanosomiasis

Buguet, Alain; Bert, J; Tapie, P; Tabaraud, F; Doua, F.; Lonsdorfer, J.; Bogui, Pascal; Dumas, Michel

doi:10.1097/00004691-199304000-00006

Cited by 83 publications

(47 citation statements)

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“…Similar results were found in the three most severely sick patients (PI. P2, P3), who had lost all circa dian rhythmicity in not only the sleep-wake cycle but also in cortisol and prolactin secretion [13,14],…”

Section: Resultsmentioning

confidence: 99%

“…The patients were ranked in terms of severity, the most severely ill patients being PI, P2 and P3. Details of the symptoms of the disease in the patients are given else where [13,14]. Due to the additional presence of severe diabetes in one of the patients (P5), his data were discarded from the study.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…Polysomnographic recordings were taken continuously through out the 24-hour period following a standard technique and the sleep data of the patients are reported elsewhere [13]. The sleep traces were scored as wakefulness, stages 1-4 of non-REM sleep, stages 3 and 4 being expressed as SWS, and REM sleep.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…Sleeping sickness or human African trypanosomiasis, induced in humans by inoculation of Trypanosoma brucei gcimbiense by the tse-tse fly, is a unique disease condition in which disruptions in the circadian cycles of sleep and wakefulness [13], and the plasma levels of cortisol and prolactin (a sleep-related hormone) develop with the pro gression of the disease [14]. Hourly plasma levels of GH were assessed in the same patients as above [13,14] and compared to the occurrence of SWS.…”

Section: Introductionmentioning

confidence: 99%

“…Hourly plasma levels of GH were assessed in the same patients as above [13,14] and compared to the occurrence of SWS. Although we realized that this sampling frequency would blunt the detection of many GH pulses [5], the condition of the patients pre vented more frequent sampling.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness

Radomski¹,

Buguet

Doua³

et al. 1996

Neuroendocrinology

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Human African trypanosomiasis (sleeping sickness) is a unique disease model of disrupted circadian rhythms in the sleep-wake cycle and cortisol and prolactin secretion. This study examined the temporal relationship between growth hormone (GH) secretion and the sleep-wake cycle in 8 infected African patients and 6 healthy indigenous African subjects. Twenty-four-hour sleep patterns were recorded by polysomnography and hourly blood samples analyzed for plasma GH. No relationships between the mean normalized plasma GH levels (Z scores) and the sleep stages (wakefulness, sleep stages 1 and 2 (‘light’ sleep), slow-wave sleep (stages 3 and 4, SWS), and rapid eye movement (REM) sleep) were found in the patients or healthy subjects. However, when the time of sampling of the plasma GH concentrations was lagged by 16 min with respect to the occurrence of the various sleep stages, significant correlations were found between plasma GH concentrations and SWS in both healthy subjects and patients. Thus, the association between SWS and GH secretion persisted even in the presence of disrupted circadian rhythms, further supporting the concept that sleep and the stimulation of GH secretion are outputs of a common mechanism.

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Section: Resultsmentioning

confidence: 99%

Section: Aterials and M Ethodsmentioning

confidence: 99%

Section: Aterials and M Ethodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness

Radomski¹,

Buguet

Doua³

et al. 1996

Neuroendocrinology

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show abstract

Function and Pharmacology of Circadian Clocks

Lundkvist

Block

2007

Handbook of Contemporary Neuropharmacology

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Biological timing systems are complex structures in higher organisms, generating biological and physiological functions with a periodicity of approximately 24 h. Knowledge of the structure and function of biological clocks has emerged from research on both invertebrate and vertebrate models. In humans, the master clock is located in the hypothalamus in the brain. Daily rhythms such as the sleep–wake cycle and hormonal rhythms can be modulated and disturbed by a number of pharmacological compounds. Drug therapy can be administered in a circadian fashion ( chronopharmacology ), thus taking into account the powerful circadian impact on drug toxicity and efficacy. This review will describe circadian systems and pharmacological impact on the timing structures.

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African Trypanosomiasis

Black¹,

Seed²

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Sleep-Wake Cycle in Human African Trypanosomiasis

Cited by 83 publications

References 0 publications

Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness

Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness

Function and Pharmacology of Circadian Clocks

African Trypanosomiasis

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