Sleep–wake disturbance in interepisode bipolar disorder and high-risk individuals: A systematic review and meta-analysis

Ng, Tommy H.; Chung, Ka Fai; Ho, Fiona Yan Yee; Yeung, Wing‐Fai; Yung, Kam Ping; Lam, Tak Ho

doi:10.1016/j.smrv.2014.06.006

Cited by 229 publications

(190 citation statements)

References 65 publications

Supporting

Mentioning

176

Contrasting

Unclassified

Order By: Relevance

“…Increased cholinergic sensitivity and REM density were noticed in remitted bipolar patients in response to the cholinergic drug arecoline [122]. A longer sleep onset latency and an altered REM onset latency are seen in both BD patients and at-risk relatives, and the latter may be the best candidates for an endophenotypic abnormality in the area of sleep [123]. …”

Section: The Phenome Of Bd From the Ion Channel Perspectivementioning

confidence: 99%

Variants in Ion Channel Genes Link Phenotypic Features of Bipolar Illness to Specific Neurobiological Process Domains

2015

View full text Add to dashboard Cite

Recent advances in genome-wide association studies are pointing towards a major role for voltage-gated ion channels in neuropsychiatric disorders and, in particular, bipolar disorder (BD). The phenotype of BD is complex, with symptoms during mood episodes and deficits persisting between episodes. We have tried to elucidate the common neurobiological mechanisms associated with ion channel signaling in order to provide a new perspective on the clinical symptoms and possible endophenotypes seen in BD patients. We propose a model in which the multiple variants in genes coding for ion channel proteins would perturb motivational circuits, synaptic plasticity, myelination, hypothalamic-pituitary-adrenal axis function, circadian neuronal rhythms, and energy regulation. These changes in neurobiological mechanisms would manifest in endophenotypes of aberrant reward processing, white matter hyperintensities, deficits in executive function, altered frontolimbic connectivity, increased amygdala activity, increased melatonin suppression, decreased REM latency, and aberrant myo-inositol/ATP shuttling. The endophenotypes result in behaviors of poor impulse control, motivational changes, cognitive deficits, abnormal stress response, sleep disturbances, and energy changes involving different neurobiological process domains. The hypothesis is that these disturbances start with altered neural circuitry during development, following which multiple environmental triggers may disrupt the neuronal excitability balance through an activity-dependent molecular process, resulting in clinical mood episodes.

show abstract

Section: The Phenome Of Bd From the Ion Channel Perspectivementioning

confidence: 99%

Variants in Ion Channel Genes Link Phenotypic Features of Bipolar Illness to Specific Neurobiological Process Domains

2015

View full text Add to dashboard Cite

show abstract

“…Such disturbances can be detected not only during acute episodes of the illness but also in remission periods. Recently, Ng et al [3] performed a meta-analysis of studies on sleep-wake disturbances in remitted bipolar patients. They concluded that a significant impairment exists in these patients regarding sleep-wake patterns, including clusters of insomnia, hypersomnia, and variability in the sleep-wake patterns.…”

Section: Introductionmentioning

confidence: 99%

A Study of Biological Rhythm Disturbances in Polish Remitted Bipolar Patients using the BRIAN, CSM, and SWPAQ Scales

Dopierała¹,

Chrobak

Kapczinski

et al. 2016

Neuropsychobiology

View full text Add to dashboard Cite

Background/Aims: The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) is a novel tool allowing for a complex assessment of biological rhythms. We compared patients with bipolar disorder (BD) and healthy control subjects (HC) using the Polish version of the BRIAN scale. Method: Fifty-four remitted BD patients (17 males and 37 females aged 52 ± 13 years) and 54 healthy control subjects (25 males and 29 females aged 42 ± 14 years) were studied. In addition to the BRIAN scale, the Composite Scale of Morningness (CSM) and the Sleep-Wake Pattern Assessment Questionnaire (SWPAQ) were employed. Results: The Polish version of the BRIAN scale displayed high feasibility and consistency, showing that the patients had greater biological rhythm disturbances than the controls. After regression analysis, significant differences were obtained for the BRIAN subscales activity and predominant chronotype, and for the SWPAQ items quality of night-time sleep and ability to stay awake. We obtained positive correlations between higher BRIAN scores and morningness and eveningness, but the correlations with vigilance and the ability to stay awake (on the SWPAQ) were negative. Conclusions: Using the BRIAN scale, we confirmed the greater disturbances of biological rhythm in Polish remitted bipolar patients, compared with healthy controls. The differences between these 2 groups in sleep-awake patterns were also demonstrated by the SWPAQ scores. In contrast to other studies, we were unable to confirm an evening chronotype as a discriminating factor between remitted bipolar patients and healthy subjects. This can be explained by the older age and the use of lithium by a significant proportion of the patients.

show abstract

“…1 Impairments in sleep-wake patterns have been reported in patients with BD, who are also more likely to have the evening chronotype than control subjects. 2,3 Brazilian investigators introduced the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) as a novel tool that allows complex assessment of biological rhythms 4 and showed that disruption in biological rhythms was greater in patients with BD than in those with major depression, and greater in both mood disorders than in community controls. 5 It is conceivable that a tendency to biological rhythm disturbances could be associated with personality dimensions, such as affective temperament and schizotypy.…”

Section: Introductionmentioning

confidence: 99%

The Biological Rhythms Interview of Assessment in Neuropsychiatry in patients with bipolar disorder: correlation with affective temperaments and schizotypy

Dopierała

Chrobak

Kapczinski

et al. 2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: To assess the relationship of biological rhythms, evaluated by the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), with affective temperaments and schizotypy. Methods: The BRIAN assessment, along with the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A) and the Oxford-Liverpool Inventory for Feelings and Experiences (O-LIFE), was administered to 54 patients with remitted bipolar disorder (BD) and 54 healthy control (HC) subjects. Results: The TEMPS-A cyclothymic temperament correlated positively and the hyperthymic temperament correlated negatively with BRIAN scores in both the BD and HC groups, although the correlation was stronger in BD subjects. Depressive temperament was associated with BRIAN scores in BD but not in HC; conversely, the irritable temperament was associated with BRIAN scores in HC, but not in BD. Several positive correlations between BRIAN scores and the schizotypal dimensions of the O-LIFE were observed in both BD and HC subjects, especially with cognitive disorganization and less so with unusual experiences and impulsive nonconformity. A correlation with introversion/ anhedonia was found only in BD subjects. Conclusion: Cyclothymic and depressive temperaments predispose to disturbances of biological rhythms in BD, while a hyperthymic temperament can be protective. Similar predispositions were also found for all schizotypal dimensions, mostly for cognitive disorganization.

show abstract

Sleep–wake disturbance in interepisode bipolar disorder and high-risk individuals: A systematic review and meta-analysis

Cited by 229 publications

References 65 publications

Variants in Ion Channel Genes Link Phenotypic Features of Bipolar Illness to Specific Neurobiological Process Domains

Variants in Ion Channel Genes Link Phenotypic Features of Bipolar Illness to Specific Neurobiological Process Domains

A Study of Biological Rhythm Disturbances in Polish Remitted Bipolar Patients using the BRIAN, CSM, and SWPAQ Scales

The Biological Rhythms Interview of Assessment in Neuropsychiatry in patients with bipolar disorder: correlation with affective temperaments and schizotypy

Contact Info

Product

Resources

About