Sleep

Nussbaumer-Ochsner, Yvonne; Bloch, Konrad E.

doi:10.1007/978-1-4614-8772-2_17

Cited by 4 publications

(2 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacological induction of hypocapnia can partially decouple the feedback loop between arterial CO 2 concentration and ventilation which drives periodic breathing 5 6. Most commonly, this is achieved with the carbonic anhydrase inhibitor acetazolamide, which has been shown to normalise periodic breathing at altitude 7.…”

Section: Introductionmentioning

confidence: 99%

Losartan may attenuate altitude-related sleep disturbance

et al. 2020

View full text Add to dashboard Cite

IntroductionSleep disturbance is common at high altitude and likely driven by an exaggerated peripheral chemoreceptor response which leads to apnoeic episodes and arousal. We hypothesised that this heightened response is in part mediated through angiotensin II receptors in the carotid body. To examine this link, we studied the effect of angiotensin II receptor blocker on sleep disturbance.MethodsTwenty participants paired by age, gender and ACE phenotype ascended to the Whymper Hut (5000 m) on Chimborazo in the Ecuadorean Andes as part of a double-blinded randomised placebo-controlled study of physiological mechanisms. Subjects were randomised to either losartan 100 mg daily or placebo. The primary outcome of sleep efficiency was measured using wrist-mounted actigraphs. One pair was excluded from analysis after descending before the end of the study due to acute mountain sickness.ResultsThere was a significantly different response to altitude between the two groups (F=3.274, p=0.029), as a decline in sleep efficiency in the placebo group (F=10.259, p<0.001) was not replicated in the angiotensin II receptor blocker group (F=0.459, p=0.713).ConclusionThe absence of any significant sleep disturbance in the intervention group suggests that peripheral chemoreceptor hypersensitivity is largely mediated by angiotensin II receptor activation. However, further research is needed to confirm our findings and to study the potential mechanisms of action.

show abstract

Section: Introductionmentioning

confidence: 99%

Losartan may attenuate altitude-related sleep disturbance

et al. 2020

View full text Add to dashboard Cite

show abstract

“…PB may disrupt sleep and be perceived as intermittent dyspnea. Therefore, sleep at high altitude is often perceived as fragmented and less restorative compared with lowlands [38].…”

Section: Introductionmentioning

confidence: 99%

Time-varying signal analysis to detect high-altitude periodic breathing in climbers ascending to extreme altitude

Garde

Giraldo

Jané

et al. 2015

Med Biol Eng Comput

View full text Add to dashboard Cite

show abstract

Patients with Obstructive Sleep Apnea at Altitude

Bloch

Latshang

Ulrich

2015

High Altitude Medicine & Biology

Self Cite

View full text Add to dashboard Cite

Bloch, Konrad E., Tsogyal D. Latshang, and Silvia Ulrich. Patients with obstructive sleep apnea at altitude. High Alt Med Biol 16:110-116, 2015.--Obstructive sleep apnea (OSA) is highly prevalent in the general population, in particular in men and women of older age. In OSA patients sleeping near sea level, the apneas/hypopneas associated with intermittent hypoxemia are predominantly due to upper airway collapse. When OSA patients stay at altitudes above 1600 m, corresponding to that of many tourist destinations, hypobaric hypoxia promotes frequent central apneas in addition to obstructive events, resulting in combined intermittent and sustained hypoxia. This induces strong sympathetic activation with elevated heart rate, cardiac arrhythmia, and systemic hypertension. There are concerns that these changes expose susceptible OSA patients, in particular those with advanced age and co-morbidities, to an excessive risk of cardiovascular and other adverse events during a stay at altitude. Based on data from randomized trials, it seems advisable for OSA patients to use continuous positive airway pressure treatment with computer controlled mask pressure adjustment (autoCPAP) in combination with acetazolamide during an altitude sojourn. If CPAP therapy is not feasible, acetazolamide alone is better than no treatment at all, as it improves oxygenation and sleep apnea and prevents excessive blood pressure rises of OSA patients at altitude.

show abstract

Sleep

Cited by 4 publications

References 60 publications

Losartan may attenuate altitude-related sleep disturbance

Losartan may attenuate altitude-related sleep disturbance

Time-varying signal analysis to detect high-altitude periodic breathing in climbers ascending to extreme altitude

Patients with Obstructive Sleep Apnea at Altitude

Contact Info

Product

Resources

About