Sleepiness and fatigue following traumatic brain injury

Beaulieu‐Bonneau, Simon; Morin, Charles M.

doi:10.1016/j.sleep.2012.02.010

Cited by 65 publications

(45 citation statements)

References 37 publications

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“…In such cases, the corresponding authors were emailed and asked to provide group means, standard deviations or sample sizes. Of the 15 authors contacted, 9-12,18-21,24-30 7 replied with the requested objective data, 11,12,19,21,[25][26][27] with 4 supplying subjective data. 9,18,24,29 Two authors were unable to provide data for all measures of interest, 10,20 but these studies were able to be included in some analyses.…”

Section: Data Extractionmentioning

confidence: 99%

“…Only a handful of studies limited their sample to mild 12,21,25,29,38 and severe TBI, 10,11,32 with the remainder of studies collapsing TBIs across the spectrum of severity. [18][19][20]24,26,27,39 Of the control samples, 10 were matched for age and gender, 11,12,18,19,[24][25][26][27]32,38 2 were matched for age, 10,20 with 4 studies not specifying. 9,21,29,39 The mean age of the control sample was 32 years (SD = 10), with a majority of the sample male (66%).…”

Section: R Esu Lt Smentioning

confidence: 99%

“…There were no other significant associations observed in meta-regression. Separate polysomnographic analysis was conducted on studies focusing on patients with mild TBI 9,12,21,25 and moderate to severe TBI 10,11,26 (Tables S4 and S5 The primary analysis of polysomnography was repeated, excluding two studies 21,25 that did not use 30-sec epochs (Table S7, supplemental material). Results remained generally consistent after the exclusion of these two studies, with the exception that there was no group difference in sleep onset latency (SMD = 0.20, CI: −0.04, 0.44, n = 286), and latency to REM sleep was significantly shorter in those with TBI (SMD = −0.26, CI: −0.49, −0.03, n = 306).…”

Section: Meta-regression and Sensitivity Analysismentioning

confidence: 99%

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Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Grima

Ponsford

Rajaratnam

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: Sleep disturbances are frequently reported following traumatic brain injury (TBI); however, the exact disturbances remain unclear. This meta-analysis aimed to characterize sleep disturbance in community dwelling patients with TBI as compared to controls. Methods: Two investigators independently conducted a systematic search of multiple electronic databases from inception to May 27, 2015. Studies were selected if they compared sleep in community dwelling individuals with TBI relative to a control population without head injury. Data were pooled in metaanalysis with outcomes expressed as the standard mean difference (SMD) and 95% confidence interval (CI). The primary outcomes were derived from polysomnography and secondary outcomes were derived from subjective sleep measures. Results: Sixteen studies were included, combining 637 TBI patients and 567 controls, all of whom were community dwelling. Pooled polysomnography data revealed that TBI patients had poorer sleep efficiency (SMD = −0. I NTRO DUCTI O NSleep disturbances are frequently reported following traumatic brain injury (TBI), with over 50% of people experiencing some form of sleep disturbance post TBI.1 Although a large majority of people with TBI generally make a good physical recovery, disrupted sleep can often go untreated, impacting quality of life, impeding rehabilitation and return to pre-injury activities.2-5 Our recent work showed significant interrelationships between daytime sleepiness, daytime fatigue, cognitive impairment, and mood disturbances in TBI. 6 While individuals with TBI are known to report sleep problems, 1 the specific changes to sleep remain poorly characterized.7 Studies have been limited by small sample sizes, with variable and inconsistent findings. [8][9][10][11][12] This makes for a difficult characterization of sleep post TBI. Thus, there is a need to establish the specific aspects of sleep that are most affected post TBI as these have important implications for treatment and rehabilitation. The aim of the current meta-analysis was to characterize both objective sleep disturbances and subjective sleep complaints in individuals with TBI relative to healthy controls. Study outcomes included the comparison of TBI patients to controls across both polysomnography and subjective measures of sleep. It ; Matthew P. Pase, PhD was hypothesized that those with TBI would display widespread objective and subjective sleep deficits as compared to controls without head injury. The present study aimed to summarize current literature, which would identify important avenues for future research. M ETHO DS Study DesignThe search strategy was conducted in accordance with the meta-analysis of observational studies in epidemiology guidelines. 13 Article SearchingOvid Medline, Embase, PsychInfo, Scopus, and the Cochrane Library were systematically searched until May, 27 2015. The search was initially developed by all authors and refined by a librarian at Monash University. The references of recent publications were also hand searc...

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Section: Data Extractionmentioning

confidence: 99%

Section: R Esu Lt Smentioning

confidence: 99%

Section: Meta-regression and Sensitivity Analysismentioning

confidence: 99%

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Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Grima

Ponsford

Rajaratnam

et al. 2016

Journal of Clinical Sleep Medicine

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“…Fatigue is often rated as the worst symptom experienced after a TBI [5,6]. Individuals with PTBIF tend to report higher levels of disability and lower satisfaction with life than individuals with TBI without fatigue complaints [7,8].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with remission of post-traumatic brain injury fatigue in the years following traumatic brain injury (TBI): a TBI model systems module study

Lequerica

Botticello

Lengenfelder

et al. 2016

Neuropsychological Rehabilitation

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“…In addition, most studies are cross-sectional and not longitudinal in terms of design. This makes it difficult to compare results across studies and to draw conclusions about sleepand fatigue changes after TBI [10,11]. Nevertheless, post-TBI sleep problems and fatigue are often consistently experienced as the most severe and distressing symptoms [5], interfering with recovery, rehabilitation treatment and negatively impacting the quality of life [12].…”

Section: Introductionmentioning

confidence: 99%

Unraveling the Biopsychosocial Factors of Fatigue and Sleep Problems After Traumatic Brain Injury: Protocol for a Multicenter Longitudinal Cohort Study (Preprint)

Bruijel¹,

Stapert²,

Vermeeren³

et al. 2018

Preprint

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Background: Fatigue and sleep problems are common after traumatic brain injury (TBI) and are experienced as highly distressing symptoms, playing a significant role in the recovery trajectory and can drastically impact the quality of life and societal participation of the patient and their family and friends. However, the etiology and development of these symptoms is still uncertain. Objective: The aim of this study is to examine the development of fatigue and sleep problems following moderate to severe TBI and explore the changes in underlying biological (pain, brain damage), psychological (emotional state) and social (support family, participation) factors across time. Methods: Longitudinal multicenter observational cohort study with four measurement points (3, 6, 12 and 18 months post injury) including subjective questionnaires and cognitive tasks, preceded by 7 nights of actigraphy combined with a sleep diary. Recruitment of 137 moderate to severe TBI patients presenting at emergency and neurology departments or rehabilitation centers across the Netherlands is anticipated. Results: The evolution of fatigue and sleep problems following TBI and their association with possible underlying biological (pain, brain damage), psychological (emotional state) and social (support family, participation) factors will be examined. Conclusion:To the authors' knowledge this study is the first study that examines the development of both post-TBI fatigue and sleep longitudinally within a biopsychosocial model in moderate to severe TBI using both subjective and objective measures. Identification of modifiable factors such as mood and psychosocial stressors may give direction to the development of interventions for fatigue and sleep problems post-TBI.

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Sleepiness and fatigue following traumatic brain injury

Cited by 65 publications

References 37 publications

Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Factors associated with remission of post-traumatic brain injury fatigue in the years following traumatic brain injury (TBI): a TBI model systems module study

Unraveling the Biopsychosocial Factors of Fatigue and Sleep Problems After Traumatic Brain Injury: Protocol for a Multicenter Longitudinal Cohort Study (Preprint)

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