Sleeping Beauty Transposon-Mediated Asparaginase Gene Delivery by a Nanoparticle Platform

Chang, Jen-Hsuan; Mou, Kurt Yun; Mou, Chung‐Yuan

doi:10.1038/s41598-019-47927-6

Cited by 10 publications

(3 citation statements)

References 37 publications

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“…It is evident that the amine-modified MSs prepared from the small 2.8 nm pore MS maintained higher selectivity in both pH 4 to 6. Amine-modified MS is reported to be positively charged in this pH range [60], in contrast to pristine MSs, which are negatively charged [61]. Therefore, the electrostatic effect seems to not be the cause of this difference.…”

Section: Effect Of Surface Modification Of Ms On Adsorption Selectivitymentioning

confidence: 83%

Amine-Modified Small Pore Mesoporous Silica as Potential Adsorbent for Zn Removal from Plating Wastewater

et al. 2022

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The removal of Zn from wastewater generated from the Zn-based electroplating manufacturing process is essential because the regulation limit of Zn concentration in wastewater is becoming stricter in Japan. However, achieving this through conventional methods is difficult, especially for small and medium enterprises in the plating industry. Therefore, a suitable Zn-removal method with a low cost but high performance and Zn selectivity is required. The application of adsorbents is one possible solution. Mesoporous silica (MS) is a well-known adsorbent with controllable pore size, high specific surface area (SSA), high acid resistance, and ease of surface modification. In this study, we modified the surfaces of MSs with different initial pore sizes by amino groups and investigated their Zn removal performances. The effect of pore size on amine modification using (3-aminopropyl)triethoxysilane and on adsorption performance in a single system was investigated along with Zn adsorption selectivity in the Zn–Ni binary system. Amine-modified MS prepared from MS with an initial pore size of 1.9 nm showed drastically lower performance compared to those prepared from MS with an initial pore size larger than 2.8 nm. Zn-selectivity in the Zn–Ni binary system, containing equal amounts of Zn and Ni, was found to reach a maximum of 21.6 when modifying MS with an initial pore size of 2.8 nm.

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Section: Effect Of Surface Modification Of Ms On Adsorption Selectivitymentioning

confidence: 83%

Amine-Modified Small Pore Mesoporous Silica as Potential Adsorbent for Zn Removal from Plating Wastewater

et al. 2022

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“…The sleeping beauty plasmids allow the stable integration of the genes into the genome of target cells and mediate their sustained expressions. Chang et al developed amine-functionalized MSNs to co-deliver the asparaginase and sleeping beauty plasmids, thereby integrating the asparaginase gene into the genome of human lung adenocarcinoma cells [ 409 ]. The intracellular expression of asparaginase induced cytotoxicity, and the combination of chemotherapy and the asparaginase gene therapy further enhanced this cytotoxicity.…”

Section: Update On Msn Applications In Nanomedicinesmentioning

confidence: 99%

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

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“…Mou et al also loaded asparaginase plasmid in MSNs to favor the expression of L-asparaginase in cancer cells, leading to significant cytotoxicity. [52] Further in vivo experiments are required to evaluate the feasibility of this nanotherapy in a more comprehensive way.…”

Section: Additional Pathwaysmentioning

confidence: 99%

Chemistry of Advanced Nanomedicines in Cancer Cell Metabolism Regulation

Yang

Shi

2020

Advanced Science

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Tumors reprogram their metabolic pathways to meet the bioenergetic and biosynthetic demands of cancer cells. These reprogrammed activities are now recognized as the hallmarks of cancer, which not only provide cancer cells with unrestricted proliferative and metastatic potentials, but also strengthen their resistance against stress conditions and therapeutic challenges. Although recent progress in nanomedicine has largely promoted the developments of various therapeutic modalities, such as photodynamic therapy, photothermal therapy, nanocatalytic therapy, tumor‐starving/suffocating therapy, etc., the therapeutic efficacies of nanomedicines are still not high enough to achieve satisfactory tumor‐suppressing effects. Therefore, researchers are obliged to look back to the essence of cancer cell biology, such as metabolism, for tailoring a proper therapeutic regimen. In this work, the characteristic metabolic pathways of cancer cells, such as aerobic respiration, glycolysis, autophagy, glutaminolysis, etc. are reviewed, to summarize the very recent advances in the smart design of nanomedicines that can regulate tumor metabolism for enhancing conventional therapeutic modalities. The underlying chemistry of these nanomedicines by which tumor metabolism is harnessed, is also discussed in a comprehensive manner. It is expected that by harnessing tumor metabolism cancer nanotherapeutics will be substantially improved in the future.

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Sleeping Beauty Transposon-Mediated Asparaginase Gene Delivery by a Nanoparticle Platform

Cited by 10 publications

References 37 publications

Amine-Modified Small Pore Mesoporous Silica as Potential Adsorbent for Zn Removal from Plating Wastewater

Amine-Modified Small Pore Mesoporous Silica as Potential Adsorbent for Zn Removal from Plating Wastewater

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

Chemistry of Advanced Nanomedicines in Cancer Cell Metabolism Regulation

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