Sleepwalking and sleep-related eating associated with atypical antipsychotic medications: Case series and systematic review of literature

Chopra, Amit; Patel, Rikinkumar S; Baliga, Nisha; Narahari, Anoop; Das, Piyush

doi:10.1016/j.genhosppsych.2020.05.014

Cited by 10 publications

(4 citation statements)

References 61 publications

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“…One-fifth of the SRED cases are related to AAPs. Quetiapine, ziprasidone, aripiprazole, lurasidone, and olanzapine have been associated with SRED [37,38]. Quetiapine stands out in terms of number of cases and disproportionality.…”

Section: Discussionmentioning

confidence: 99%

Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis

Merino

Gérard

Obberghen

et al. 2022

JCM

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Sleep-related eating disorder (SRED) is a parasomnia with recurrent, involuntary, amnestic eating episodes during sleep. There is growing evidence of the association between SRED and medications. Therefore, we aimed to rank drugs showing the strongest association. VigiBase® (WHO pharmacovigilance database) was queried for all reports of “Sleep-related eating disorder”. Disproportionality analysis relied on the Reporting Odds Ratio, with its 95% Confidence Interval (CI), and the Information Component. Our VigiBase® query yielded 676 cases of drug-associated SRED. Reports mostly involved zolpidem (243, 35.9%), sodium oxybate (185, 27.4%), and quetiapine (97, 14.3%). Significant disproportionality was found for 35 medications, including zolpidem (387.6; 95%CI 331.2–453.7), sodium oxybate (204.2; 95%CI 172.4–241.8), suvorexant (67.3; 95%CI 38.0–119.2), quetiapine (53.3; 95%CI 43.0–66.1), and several psychostimulants and serotonin-norepinephrine reuptake inhibitors (SNRIs). Patients treated with nonbenzodiazepines or SNRIs were significantly older (mean age: 49.0 vs. 37.5; p < 0.001) and their SRED were more likely to be serious (62.6% vs. 51.4%; p = 0.014) than patients treated with sodium oxybate or psychostimulants. Psychotropic drugs are involved in almost all reports. In patients with SRED, an iatrogenic trigger should be searched for.

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Section: Discussionmentioning

confidence: 99%

Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis

Merino

Gérard

Obberghen

et al. 2022

JCM

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“…6 This dissociation between both the state of partial arousal and muscle hypotonia enables sleepwalking. 2,14 Among the antipsychotics, SRED was found to be precipitated more commonly with quetiapine 15 It has been suggested that very low doses of quetiapine can induce SW. 8 • Antagonism of the serotonin receptor 5-HT2C in the hypothalamus increases appetite leading to food intake and weight gain. 16 • Patients who are on antipsychotics and gaining weight were found to have associated elevated leptin levels.…”

Section: Discussionmentioning

confidence: 99%

Quetiapine‐induced sleep‐related eating disorder: A case report

Kanagasundram

2021

Clinical Case Reports

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“…SRED has indeed been rarely described in patients with PD, particularly when coexistent untreated sleep disturbances (OSA, PLM or REM-sleep behavior disorder-RBD) leading to sleep fragmentation exist [77] or, anecdotally, as side effect of pramipexole utilization [78]. Atypical antipsychotic drugs and mirtazapine had also been associated with SRED episodes [79][80][81]. SRED can potentially lead to the unconscious ingestion of toxic substances, making it crucial for sleep physicians to make every effort to identify and eliminate any triggers in affected patients.…”

Section: Sred and Coexistent Sleep Disordersmentioning

confidence: 99%

“…The literature studies identified that NT1 patients present a higher rate of binge eating, bulimia and/or other compulsive eating behaviors [79]. Furthermore, narcoleptic patients lower metabolic rate compared to age-matched healthy controls.…”

Section: Narcolepsy and Eating Disordersmentioning

confidence: 99%

Sleep Pathologies and Eating Disorders: A Crossroad for Neurology, Psychiatry and Nutrition

Mutti,

Malagutti,

Maraglino

et al. 2023

Nutrients

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The intricate connection between eating behaviors and sleep habits is often overlooked in clinical practice, despite their profound interdependence. Sleep plays a key role in modulating psychological, hormonal and metabolic balance and exerting an influence on food choices. Conversely, various eating disorders may affect sleep continuity, sometimes promoting the development of sleep pathologies. Neurologists, nutritionists and psychiatrists tend to focus on these issues separately, resulting in a failure to recognize the full extent of the clinical conditions. This detrimental separation can lead to underestimation, misdiagnosis and inappropriate therapeutic interventions. In this review, we aim to provide a comprehensive understanding of the tangled relationship between sleep, sleep pathologies and eating disorders, by incorporating the perspective of sleep experts, psychologists and psychiatrists. Our goal is to identify a practical crossroad integrating the expertise of all the involved specialists.

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Sleepwalking and sleep-related eating associated with atypical antipsychotic medications: Case series and systematic review of literature

Cited by 10 publications

References 61 publications

Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis

Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis

Quetiapine‐induced sleep‐related eating disorder: A case report

Sleep Pathologies and Eating Disorders: A Crossroad for Neurology, Psychiatry and Nutrition

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