Sliding contact accelerates solute transport into the cartilage surface compared to axial loading

Culliton, Kathryn Nicole; Speirs, Andrew

doi:10.1016/j.joca.2021.05.060

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…The high stiffness of cartilage is attributed to the viscoelastic and poroelastic dissipation of the tissue networks [ 27 , 28 ]. Abundant strong collagen fibers interpenetrate with proteoglycan macromolecules in the articular cartilage, which provides viscoelasticity and poroelasticity for mechanical dissipation [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Ding

Liu

Zhao

et al. 2022

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Ding

Liu

Zhao

et al. 2022

Bioactive Materials

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Study on ultrasound-enhanced molecular transport in articular cartilage

Wang,

Tan,

Gao

et al. 2024

Drug Deliv. and Transl. Res.

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Integrins, cadherins and channels in cartilage mechanotransduction: perspectives for future regeneration strategies

Dieterle

Husari

Rolauffs

et al. 2021

Expert Rev. Mol. Med.

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Articular cartilage consists of hyaline cartilage, is a major constituent of the human musculoskeletal system and has critical functions in frictionless joint movement and articular homoeostasis. Osteoarthritis (OA) is an inflammatory disease of articular cartilage, which promotes joint degeneration. Although it affects millions of people, there are no satisfying therapies that address this disease at the molecular level. Therefore, tissue regeneration approaches aim at modifying chondrocyte biology to mitigate the consequences of OA. This requires appropriate biochemical and biophysical stimulation of cells. Regarding the latter, mechanotransduction of chondrocytes and their precursor cells has become increasingly important over the last few decades. Mechanotransduction is the transformation of external biophysical stimuli into intracellular biochemical signals, involving sensor molecules at the cell surface and intracellular signalling molecules, so-called mechano-sensors and -transducers. These signalling events determine cell behaviour. Mechanotransducing ion channels and gap junctions additionally govern chondrocyte physiology. It is of great scientific and medical interest to induce a specific cell behaviour by controlling these mechanotransduction pathways and to translate this knowledge into regenerative clinical therapies. This review therefore focuses on the mechanotransduction properties of integrins, cadherins and ion channels in cartilaginous tissues to provide perspectives for cartilage regeneration.

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Sliding contact accelerates solute transport into the cartilage surface compared to axial loading

Cited by 4 publications

References 26 publications

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Study on ultrasound-enhanced molecular transport in articular cartilage

Integrins, cadherins and channels in cartilage mechanotransduction: perspectives for future regeneration strategies

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