“…Such open questions include function, molecular mechanism, morphological characteristics of the nano-hierarchical structures, mechanism of frictional adhesion, tail function during climbing or aerial descent, and interactive effects of size and loading on kinematics. The milli seconds controllable attachment=detachment mechanism in geckos with negligible forces assumed a huge importance also from a technological point of view, e.g., fabrication of dry adhesives, robotics systems, artificial adhesive suits, and gloves for astronauts [21,23,30,[35][36][37][38][39][40][41]; this is achieved thanks to the uniqueness of the gecko adhesive system in terms of repeatable strong foot contacts combined with temporary and reversible weak bonds, basically intermolecular van der Waals forces [14,30,33,[42][43][44]. In order to maintain the necessary shear=frictional adhesive [12] forces and to avoid toe detachment, the gecko adhesive mechanism is based on the use of opposing feet and toes making a V-shaped geometry and the gecko attachment being achieved only proximally along the toe axis of the gecko, which pulls its feet inwards towards the center of mass (COM) and its toes inwards towards the foot to engage adhesion [14,21,30,31,34,45,46], as schematically reported in Fig.…”