In this paper, based on the parametric design of 3 D blades including typical cross-section and natural frequency calculation of the equivalent model, an integral method for aerodynamic performance and aeroelastic vibration analysis of blade with Gurney flap is proposed. Parametric design and unstructured grid are used to pre-process the blades with/without the Gurney flap. The discrete aerodynamic performance parameters distribution including the lift, drag, and torsion coefficients calculated by Fluent is fitted by the nonlinear least square method based on the trust-region algorithm, and the natural frequencies of the rotating blade are accurately solved by the equivalent thin-walled beam model and Green’s functions. Based on the aerodynamic performance coefficients and natural frequencies obtained by the accurate calculation above, the aeroelastic response equation of typical cross-section considering local aerodynamic damping matrix is established, and the vibration response of blade in flap and torsion direction is further described. From the analysis results, it can be seen that the Gurney flap structure can not only bring higher lift performance to the blade, but also can reduce the amplitude and vibration range of aeroelastic vibration, improve the aeroelastic stability of the blade, and prove the effectiveness of Gurney flap.