Sliding thin slab, minimum intensity projection technique in the diagnosis of emphysema: histopathologic-CT correlation.

Rémy‐Jardin, Martine; Rémy, Jacques; Gosselin, B; Copin, Marie‐Christine; Würtz, A.; Duhamel, Alain

doi:10.1148/radiology.200.3.8756912

Cited by 101 publications

(48 citation statements)

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“…Therefore, studies can be tailored to the clinical or research question being asked in order to maximise image quality whilst minimising the radiation dose. Volumetric CT also allows the generation of maximal intensity projection and minimal intensity projection (MIN-IPS) images, and MIN-IPS images have been shown to be particularly helpful in the detection of subtle emphysema [5].…”

Section: General Methodsmentioning

confidence: 99%

Computed tomographic imaging of the airways: relationship to structure and function

Jong

Müller²,

Paré³

et al. 2005

Eur Respir J

157

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Alterations in the structure of the airways, collectively termed airway remodelling, contribute to airflow obstruction in a variety of chronic lung diseases. While histology has provided valuable insights into the structure of airway wall remodelling, this technique is invasive and does not allow the longitudinal analysis of airway wall dimensions. Technical advances in computed tomography allow the assessment of airway wall dimensions, and are ideally suited for the noninvasive investigation of the pathogenesis of airway wall remodelling and the evaluation of new therapeutic interventions. The aim of this article is to review the use of computed tomography in the investigation of airway structure and function in health and disease.

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Section: General Methodsmentioning

confidence: 99%

Computed tomographic imaging of the airways: relationship to structure and function

Jong

Müller²,

Paré³

et al. 2005

Eur Respir J

157

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“…HRCT imaging detects early emphysema by identifying pulmonary tissue with radiologic attenuation below a predetermined threshold, findings that roughly correlate with a low DL CO and pathologic evidence of emphysema (74)(75)(76)(77)(78)(79)(80). Although several studies have shown that a significant proportion of asymptomatic smokers have HRCT evidence of emphysema (78,(81)(82)(83), early HRCT findings of ''emphysema'' are not proven to be correlated directly with lung destruction (84)(85)(86)(87)(88)(89)(90). Hyperpolarized gas diffusion-weighted magnetic resonance imaging has also been used to identify emphysema, with a correlation of elevated levels of the apparent diffusion coefficient with decreased DL CO (91).…”

Section: Early Detection Of Lung Destructionmentioning

confidence: 99%

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

Gordon

Gudi

Krause

et al. 2011

Am J Respir Crit Care Med

205

173

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Rationale: There is increasing evidence that emphysema is associated with primary loss of pulmonary capillary endothelium. Plasma levels of endothelial microparticles (EMPs), small vesicles released from activated or apoptotic endothelial cells, are elevated in vascularrelated disorders. Objectives: To evaluate whether plasma EMP levels are elevated in smokers with early lung destruction as assessed by normal spirometry but reduced diffusing capacity of the lung for carbon monoxide (DL CO ). Methods: Lung health was assessed by pulmonary function tests (PFTs: spirometry, total lung capacity, DL CO ) and chest X-ray; smoking status was assessed by urine nicotine and cotinine. EMP levels (CD42b 2 CD31 1 microparticles) were quantified as activated or apoptotic. The initial cohort (n 5 92) included healthy nonsmokers (normal PFTs), healthy smokers (normal PFTs), and smokers with early evidence of lung destruction (normal spirometry, low DL CO ). Two prospective cohorts were then tested: a group similar to the initial cohort and an HIV1 1 cohort. Measurements and Main Results: Healthy smokers had mildly increased levels of EMPs. Strikingly, 95% of smokers with normal spirometry, low DL CO had increased EMPs, with reduced CD62 1 / CD31 1 ratios (P , 10 24 ) and elevated CD42b 2 CD31 1 annexin V 1 EMPs (P , 10 24 ), suggesting derivation from endothelial apoptosis. Most elevated EMPs were angiotensin-converting enzyme positive, suggesting derivation from pulmonary capillaries. Both prospective cohorts confirmed the initial cohort data. Conclusions: Plasma EMPs with apoptotic characteristics are elevated in smokers with normal spirometry but reduced DL CO , consistent with the concept that emphysema is associated, in part, with capillary endothelium apoptosis, suggesting that the early development of emphysema might be monitored with plasma EMP levels.

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“…Moreover, comparisons [28] or correlations [29,30] between CT and microscopic morphometry usually fail in mild emphysema. Several morphological criteria have been suggested for the microscopic definition of emphysema, including an increase in AIA, Lm or DI.…”

mentioning

confidence: 99%

Helium-3 MRI diffusion coefficient: correlation to morphometry in a model of mild emphysema

Ruíz-Cabello²,

et al. 2003

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Hyperpolarised gases have been most recently used in magnetic resonance imaging to demonstrate new image-derived pulmonary function parameters. One of these parameters is the apparent diffusion coefficient, which reflects the sizes of the structures that compartmentalise gas within the lung (i.e. alveolar space). In the present study, noninvasive parameters were compared to microscopic measurements (mean linear intercept and mean alveolar internal area).Nonselective helium-3 gas density coronal ex vivo images and apparent diffusion maps were acquired in control and elastase-induced panacinar emphysema rats. Total lung capacity was considered the reference for both imaging experiments and lung fixation.A mild degree of emphysema was found based on mean linear intercept (134¡25 mm) versus control (85¡14 mm). The apparent diffusion coefficients were significantly different between the two groups (0.18¡0.02 and 0.15¡0.01 cm 2 ?s -1 for elastase and control, respectively).A significant correlation between the apparent diffusion coefficient and corresponding morphometric parameters in mild emphysema was demonstrated for the first time. This study opens the possibility of estimating absolute airspace size using noninvasive techniques.

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Sliding thin slab, minimum intensity projection technique in the diagnosis of emphysema: histopathologic-CT correlation.

Abstract: The sliding thin slab, minimum intensity projection technique enabled improved detection of mild forms of emphysema.

Cited by 101 publications

References 0 publications

Computed tomographic imaging of the airways: relationship to structure and function

Computed tomographic imaging of the airways: relationship to structure and function

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

Helium-3 MRI diffusion coefficient: correlation to morphometry in a model of mild emphysema

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