Slime Production by <i>Pseudomonas aeruginosa</i>

Murakawa, Takeo

doi:10.1111/j.1348-0421.1973.tb00937.x

Cited by 23 publications

(2 citation statements)

References 25 publications

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“…The presence of DNA in the EPS and its responsibility for the stickiness of the by then so called “slime” or “mats” was discovered as early as in 1955 for some halophilic bacteria (Smithies and Gibbons 1955 ) and several years later with a focus on human pathogens for Pseudomonas aeruginosa (Murakawa 1973 ). Beginning in 1996, exDNA was increasingly noted in the EPS matrix of activated sludge and in pure cultures of Pseudomonas putida (reviewed by Flemming and Wingender 2010 ).…”

Section: Biofilmsmentioning

confidence: 99%

Extracellular DNA in natural environments: features, relevance and applications

Nagler

Insam

Pietramellara

et al. 2018

Appl Microbiol Biotechnol

190

151

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Extracellular DNA (exDNA) is abundant in many habitats, including soil, sediments, oceans and freshwater as well as the intercellular milieu of metazoa. For a long time, its origin has been assumed to be mainly lysed cells. Nowadays, research is collecting evidence that exDNA is often secreted actively and is used to perform a number of tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental and general microbiological applications. The present review gives an overview on the main research areas dealing with exDNA, depicts its inherent origins and functions and deduces the potential of existing and emerging exDNA-based applications. Furthermore, it provides an overview on existing extraction methods and indicates common pitfalls that should be avoided whilst working with exDNA.

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Section: Biofilmsmentioning

confidence: 99%

Extracellular DNA in natural environments: features, relevance and applications

Nagler

Insam

Pietramellara

et al. 2018

Appl Microbiol Biotechnol

190

151

View full text Add to dashboard Cite

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“…eDNA has been recognized as a potential constituent of the in vivo biofilm matrix since at least the 1970s, when analysis of the “slime” produced by several clinical isolates of P. aeruginosa revealed the presence of DNA ( Murakawa, 1973 ). For many years, eDNA in biofilms was thought to be mostly a byproduct of lysed cells with unclear functional significance ( Sutherland, 2001 ).…”

Section: Intrinsic and Extrinsic Factors Affecting Tissue-associated ...mentioning

confidence: 99%

Bacterial biofilms in the human body: prevalence and impacts on health and disease

Perry,

Tan

2023

Front. Cell. Infect. Microbiol.

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Bacterial biofilms can be found in most environments on our planet, and the human body is no exception. Consisting of microbial cells encased in a matrix of extracellular polymers, biofilms enable bacteria to sequester themselves in favorable niches, while also increasing their ability to resist numerous stresses and survive under hostile circumstances. In recent decades, biofilms have increasingly been recognized as a major contributor to the pathogenesis of chronic infections. However, biofilms also occur in or on certain tissues in healthy individuals, and their constituent species are not restricted to canonical pathogens. In this review, we discuss the evidence for where, when, and what types of biofilms occur in the human body, as well as the diverse ways in which they can impact host health under homeostatic and dysbiotic states.

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