Abstract. In tsunami waveform inversion using the conventional Green's function technique, an optimal solution is sometimes difficult to obtain because of various factors. This study proposes a new method to both optimize the determination of the unknown parameters and introduce a global optimization method for tsunami waveform inversion. We utilize a genetic algorithm that further enhanced by a pattern search method to find an optimal distribution of unit source locations prior to the inversion. Unlike the conventional method that characterized by equidistant unit sources, our method generates a random spatial distribution of unit sources inside the inverse region. This leads to a better approximation of the initial profile of a tsunami. The method has been tested using an artificial tsunami source with real bathymetry data. Comparison results demonstrate that the proposed method has considerably outperformed the conventional one in terms of model accuracy.