2024
DOI: 10.1101/2024.03.28.587146
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SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulation

Doyeong Ku,
Yewon Yang,
Youngran Park
et al.

Abstract: Viral and endogenous double-stranded RNAs (dsRNAs) are recognized by cytosolic sensors and initiate antiviral signaling as a part of innate responses. Recent studies reveal a close association between mitochondrial dsRNAs (mt-dsRNAs) and several immune-related diseases. However, the mechanism by which mt-dsRNAs stimulate immune responses remains poorly understood. Here, we discover SRA stem-loop interacting RNA binding protein (SLIRP) as a key amplifier of mt-dsRNA-triggered antiviral signals in the setting of… Show more

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