SLIT’s Prevention of the Allergic March

Porcaro, Federica; Corsello, Giovanni; Pajno, Giovanni Battista

doi:10.1007/s11882-018-0785-7

Cited by 15 publications

(14 citation statements)

References 98 publications

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“…The prevalence of allergic diseases including allergic rhinoconjunctivitis (ARC) and allergic asthma has in recent decades increased among children and adolescents, affecting quality of life, sleeping patterns, and school performance, along with high socioeconomic costs . Furthermore, it is well established that prevalence of ARC predisposes for development of allergic asthma, pointing at the importance of intervening at an early time point. As today's treatment options for ARC mainly comprise symptomatic pharmacotherapy often accompanied by side effects, there is a great need of better treatment options.…”

Section: Introductionmentioning

confidence: 99%

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

Huoman

Papapavlou

Pap

et al. 2019

Pediatric Allergy Immunology

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Background: Immunomodulatory effects of sublingual immunotherapy on systemic and mucosal mediators in allergic children are largely unexplored. The aim of this study was to investigate allergy-related cytokine and chemokine levels, as well as IgA-responses upon a 3-year treatment with timothy grass pollen sublingual immunotherapy in children with allergic rhinoconjunctivitis.Methods: From children included in the GRAZAX ® Asthma Prevention study, blood and saliva samples were analyzed at inclusion, after 3 years of treatment, and 2 years after treatment ending. By means of Luminex and ELISA methodologies, allergy-related cytokines and chemokines were measured in plasma samples and allergen-stimulated peripheral blood mononuclear cell supernatants. Furthermore, studies of total, secretory, and Phl p 1-specific salivary IgA antibodies were performed using the same methods.Results: GRAZAX ® -treated children exhibited significantly higher levels of Phl p 1specific salivary IgA and serum IgG 4 , along with significantly lower skin prick test positivity, after 3 years of treatment and 2 years after treatment cessation.Additionally, plasma levels of the Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in treated than untreated children at these time points.Timothy-induced ratios of IL-5/IL-13 over IFN-γ were significantly decreased after 3 years with active treatment, as were symptoms of allergic rhinitis in terms of both severity and visual analogue scale scores. However, no consistent correlations were found between the clinical outcomes and immunologic parameters. Conclusion: Phleum pratense sublingual immunotherapy in grass pollen allergic children modulates the immune response in the oral mucosa as well as systemically-by increasing Th1-responses, decreasing Th2-responses, and inducing immunoregulatory responses-all signs of tolerance induction. | 523 HUOMAN et Al.

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Section: Introductionmentioning

confidence: 99%

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

Huoman

Papapavlou

Pap

et al. 2019

Pediatric Allergy Immunology

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“…Immunotherapy was shown to be effective in the supression of all phases of allergic responses (13) . Also immunotherapy was shown to be effective in preventing development of new sensitizations and allergies (14,15) .…”

Section: Discussionmentioning

confidence: 99%

Is house dust mite spesific sublingual immunotherapy successful in termination of inhaled corticosteroid treatment in children with asthma?

Erolu¹,

Aydıner²,

Barış³

et al. 2018

İKSST

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Objective: House dust mite (HDM)-specific sublingual immunotherapy (SLIT) has long-term effects contrary to pharmacotherapy in children with asthma. We aimed to study the long-term effects of SLIT on inhaled corticosteroid usage. Material and Method: Fifty-four asthmatic children who received HDM-specific SLIT for at least 3 years and were followed up for a minimum 5 years after cessation of SLIT in addition to pharmacotherapy and 23 patients who received only pharmacotherapy during the same time period were admitted in the study. SLIT and pharmacotherapy groups were evaluated retrospectively by scanning their medical records in regard to their inhaled corticosteroid (ICS) dose (μg/day), duration (month(s)/year) of ICS, and pulmonary function test (PFT) parameters. Visual analogue scores and symptom scores recorded for 6 months in their daily record cards given to them were evaluated, and dose (μg/day), and duration of ICS therapy (month(s)/year) were calculated PFTs were performed for each patient. Based on the diary card records regarding symptoms, the need for ICS and FEV1%, the patients were grouped as 37 SLIT-responders, 17 SLIT-nonresponders, 15 PT-responders, and 8 PT-nonresponders. Results: Reduction in ICS dose was significantly higher for SLIT (407±252 μg)n group in comparison to pharmacotherapy group (224±174 μg) (p=0.009). Duration of ICS usage reduced by 63% (p=0,001) in SLIT-nonresponder group, but in pharmacotherapynonresponder group it decreased by only 11% (p=0,108). Conclusion: SLIT was effective in reducing ICS dose. Duration of ICS treatment did not decrease in the course of time in PT-nonresponder group while decreased in SLIT-nonresponder group.

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“…Sublingual allergen immunotherapy (SLIT) comprises sublingual (oral) administration of a certain amount of allergen extract which causes the allergy [13]. However, biodistribution studies have shown the lack of systemic absorption of allergen through the oral mucosa after sublingual administration.…”

Section: General Methods and Novel Approaches Of Administrationmentioning

confidence: 99%

“…These antigen-specific IgG antibodies can block the allergic inflammation cascade outcome of antigen recognition by IgE. Furthermore, Tregs suppress IgE production via downregulating cytokine production in Th2 cells [13].…”

Section: Slit Mechanismsmentioning

confidence: 99%

Diverse Mechanisms of Allergen Specific Immunotherapy

Cevhertas

Лацин

Akdiş

et al. 2019

Vestn. Ross. univ. družby nar., Ser. Med.

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Allergen immunotherapy (AIT) is widely used to establish a tolerant immune response and it is currently the only disease modifying treatment. There are different routes to administer the allergen, including subcutaneous, sublingual, intralymphatic, epicutaneous, intradermal, and oral and local nasal allergen immunotherapy. Although the optimal administration route depends on the type of allergen, some patients remain unresponsive and so it is important to predict the outcome before and during treatment. Therefore, there is a need to identify candidate prognostic markers for allergen immunotherapy. Herein, we discuss the recent literature on the molecular mechanisms of AIT.

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SLIT’s Prevention of the Allergic March

Cited by 15 publications

References 98 publications

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

Is house dust mite spesific sublingual immunotherapy successful in termination of inhaled corticosteroid treatment in children with asthma?

Diverse Mechanisms of Allergen Specific Immunotherapy

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