Slit3 regulates cell motility through Rac/Cdc42 activation in lipopolysaccharide‐stimulated macrophages

Tanno, Toshihiko; Fujiwara, Ayumi; Sakaguchi, Kunihiko; Tanaka, Katsuhiro; Takenaka, Shigeo; Tsuyama, Shingo

doi:10.1016/j.febslet.2007.02.001

Cited by 28 publications

(26 citation statements)

References 22 publications

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“…10,[21][22][23] Recently, Slit3 was implicated in modulating the motility of macrophages. 37 These observations suggest that Slit3 may also modulate EC motility. Cell motility includes 2 types of cell movement, the autonomous migration and chemotaxis.…”

Section: Slit3 Is Chemoattractant For Ecsmentioning

confidence: 93%

Repulsive axon guidance molecule Slit3 is a novel angiogenic factor

Zhang

Dietrich

Geng

et al. 2009

Blood

135

146

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Slits are large, secreted repulsive axon guidance molecules. Recent genetic studies revealed that the Slit3 is dispensable for neural development but required for non-neuron-related developmental processes, such as the genesis of the diaphragm and kidney. Here we report that Slit3 potently promotes angiogenesis, a process essential for proper organogenesis during embryonic development. We observed that Slit3 is expressed and se-

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Section: Slit3 Is Chemoattractant For Ecsmentioning

confidence: 93%

Repulsive axon guidance molecule Slit3 is a novel angiogenic factor

Zhang

Dietrich

Geng

et al. 2009

Blood

135

146

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“…Hypermethylation at the SLIT3 5′ CpG island occurs in colorectal cancers (11). SLIT3 likely plays a role in inflammation: the expression of SLIT3 increases after LPS stimulation of mouse macrophages (60), and this gene has been associated with BMI in a GWAS for obesity (41). …”

Section: Gwas Reveal Tissues Pathways and Genes Consistently Associmentioning

confidence: 99%

The Relationship Between the Human Genome and Microbiome Comes into View

et al. 2017

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The microbiome’s involvement in health and disease, and the complexity of its composition and function, make it intriguing to consider human genetic factors that impact microbiome composition. Genes may influence health through their ability to promote a stable microbial community in the gut. Studies of heritability yield a consistent subset of microbes that are impacted by genes, but the use of genome-wide association studies (GWAS) to identify specific genetic variants associated with microbiota phenotypes has proven challenging. Processing microbiome datasets into traits to be modeled and reducing the burden of multiple testing are just some of the technical hurdles in microbiome GWAS. Studies to date are small by GWAS standards, making cross-study comparisons and validations particularly important in identifying authentic signals. Cross-study comparisons are hampered by differences in analytical approaches. Nevertheless, some consistent associations have emerged between populations, most notably between Bifidobacteria and the lactase non-persister genotype. These early successes open the way for the microbiome to be incorporated into studies that quantify interactions among genotype, environment, and the microbiome for predicting disease susceptibility.

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“…LPS is well documented to elicit a variety of cellular activities including cell mobilization in macrophages [4,28]. To examine the effect of butyrate on macrophage motility, the migratory potential of RAW264.7 macrophages treated without or with butyrate (2 mM) prior to LPS exposure was determined.…”

Section: Butyrate Inhibits Lipopolysaccharide-induced Macrophage Migrmentioning

confidence: 99%