SLN for topical application in skin diseases—Characterization of drug–carrier and carrier–target interactions

Küchler, Sarah; Herrmann, W. M.; Panek-Minkin, G.; Blaschke, Tobias; Zoschke, Christian; Kramer, K.D.; Bittl, Robert; Schäfer‐Korting, Monika

doi:10.1016/j.ijpharm.2010.02.004

Cited by 63 publications

(34 citation statements)

References 30 publications

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“…ESR requires a paramagnetic spin probes to investigate SLN dispersions. Direct, repeatable, and noninvasive characterization of the distribution of the spin probe between the aqueous and the lipid phase can be performed by ESR (78,80). However, despite the great potential, NMR and ESR have been rarely applied to characterize SLNs and NLCs.…”

Section: Assessment Of Alternative Colloidal Structuresmentioning

confidence: 99%

Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery

2010

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Abstract. Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially lipophilic compounds. These formulations may also be used for sustained drug release. Solid lipid nanoparticle (SLN) and the newer generation lipid nanoparticle, nanostructured lipid carrier (NLC), have been studied for their capability as oral drug carriers. Biodegradable, biocompatible, and physiological lipids are generally used to prepare these nanoparticles. Hence, toxicity problems related with the polymeric nanoparticles can be minimized. Furthermore, stability of the formulations might increase than other liquid nano-carriers due to the solid matrix of these lipid nanoparticles. These nanoparticles can be produced by different formulation techniques. Scaling up of the production process from lab scale to industrial scale can be easily achieved. Reasonably high drug encapsulation efficiency of the nanoparticles was documented. Oral absorption and bioavailability of several drugs were improved after oral administration of the drugloaded SLNs or NLCs. In this review, pros and cons, different formulation and characterization techniques, drug incorporation models, GI absorption and oral bioavailability enhancement mechanisms, stability and storage condition of the formulations, and recent advances in oral delivery of the lipid nanoparticles based on solid matrix will be discussed.

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Section: Assessment Of Alternative Colloidal Structuresmentioning

confidence: 99%

Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery

2010

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“…SLNs also represent a promising carrier system for cosmetic active ingredients because of their numerous advantages over existing conventional formulations. [8][9][10][11] There are different approaches to modulating the penetration of active ingredients into the skin. In general, increased penetration is desirable in cases of pharmaceutical purposes, either accumulation of drug in the upper skin layer for local treatment or to achieve permeation of the skin leading to systemic absorption.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

Adib¹,

Ghanbarzadeh²,

Kouhsoltani³

et al. 2016

Adv Pharm Bull

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“…Yet, until today there is only limited data on the mechanism of drug transport into the skin [7,10] . Making contact with the skin surface, the carrier matrix appears to dissolve, and this favors the interaction of carrier lipids and skin lipids and the penetration of the loaded guest molecules [11][12][13] . Interestingly, uptake from SLNs is clearly superior to uptake from particles built up from both solid lipids and oils (nanostructured lipid carriers) [14,15] .…”

Section: Introductionmentioning

confidence: 99%

Drug Release and Skin Penetration from Solid Lipid Nanoparticles and a Base Cream: A Systematic Approach from a Comparison of Three Glucocorticoids

Schlupp

Blaschke²,

Kramer³

et al. 2011

Skin Pharmacol Physiol

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Solid lipid nanoparticles (SLNs) can enhance drug penetration into the skin, yet the mechanism of the improved transport is not known in full. To unravel the influence of the drug-particle interaction on penetration enhancement, 3 glucocorticoids (GCs), prednisolone (PD), the diester prednicarbate (PC) and the monoester betamethasone 17-valerate (BMV), varying in structure and lipophilicity, were loaded onto SLNs. Theoretical permeability coefficients (cm/s) of the agents rank BMV (–6.38) ≧ PC (–6.57) > PD (–7.30). GC-particle interaction, drug release and skin penetration were investigated including a conventional oil-in-water cream for reference. Both with SLN and cream, PD release was clearly superior to PC release which exceeded BMV release. With the cream, the rank order did not change when studying skin penetration, and skin penetration is thus predominantly influenced by drug release. Yet, the penetration profile for the GCs loaded onto SLNs completely changed, and differences between the steroids were almost lost. Thus, SLNs influence skin penetration by an intrinsic mechanism linked to a specific interaction of the drug-carrier complex and the skin surface, which becomes possible by the lipid nature and nanosize of the carrier and appears not to be derived by testing drug release. Interestingly, PC and PD uptake from SLN even resulted in epidermal targeting. Thus, SLNs are not only able to improve skin penetration of topically applied drugs, but may also be of particular interest when specifically aiming to influence epidermal dysfunction.

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SLN for topical application in skin diseases—Characterization of drug–carrier and carrier–target interactions

Cited by 63 publications

References 30 publications

Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery

Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery

The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

Drug Release and Skin Penetration from Solid Lipid Nanoparticles and a Base Cream: A Systematic Approach from a Comparison of Three Glucocorticoids

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