Slot Waveguide with Grating Based Cladding for Protein Detection

Sulabh,; Kumar, Mukesh

doi:10.1007/978-981-15-9259-1_113

Cited by 1 publication

(1 citation statement)

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“…Structuring (the creation of periodic and aperiodic structures) slot WGs allows one to enhance interaction or to expand the detection methods. In [ 314 ] the detection of hemoglobin, globulin and BSA protein in aqueous analyte by slot WG with grating with sensitivity of 600 nm/RIU and Q factor of 9650 (refractometry) is described. Slot WGs are also used as nanophotonic traps for nanoparticles (NPs) and biomolecules [ 347 ].…”

Section: Label-free Optical Techniques Of Protein Detection Quantific...mentioning

confidence: 99%

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

et al. 2022

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Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. There is a growing tendency towards using portable diagnostic biosensor devices for point-of-care (POC) analysis based on microfluidic technology as an alternative to conventional laboratory protein assays. In contrast to universally accepted analytical methods involving protein labeling, label-free approaches often allow the development of biosensors with minimal requirements for sample preparation by omitting expensive labelling reagents. The aim of the present work is to review the variety of physical label-free techniques of protein detection and characterization which are suitable for application in micro-fluidic structures and analyze the technological and material aspects of label-free biosensors that implement these methods. The most widely used optical and impedance spectroscopy techniques: absorption, fluorescence, surface plasmon resonance, Raman scattering, and interferometry, as well as new trends in photonics are reviewed. The challenges of materials selection, surfaces tailoring in microfluidic structures, and enhancement of the sensitivity and miniaturization of biosensor systems are discussed. The review provides an overview for current advances and future trends in microfluidics integrated technologies for label-free protein biomarkers detection and discusses existing challenges and a way towards novel solutions.

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Section: Label-free Optical Techniques Of Protein Detection Quantific...mentioning

confidence: 99%