Slow-slip events are earthquake-like events only with much lower slip rates. While peak coseismic velocities can reach tens of meters per second, slow-slip is on the order of 10 −7±2 m/s and may last for days to weeks. Under the rate-and-state model of fault friction, slow-slip is produced only when the asperity size is commensurate with the critical nucleation size, a function of frictional properties. However, it is unlikely that all subduction zones embody the same frictional properties. In addition to friction, plastic flow of antigorite-rich serpentinite may significantly influence the dynamics of fault slip near the mantle wedge corner. Here, we show that the range of frictional parameters that generate slow slip is widened in the presence of a serpentinized layer along the subduction plate interface. We observe increased stability and damping of fast ruptures in a semi-brittle fault zone governed by both brittle and viscoelastic constitutive response. The rate of viscous serpentinite flow, governed by dislocation creep, is enhanced by high ambient temperatures. When effective viscosity is taken to be dynamic, long-term slow slip events spontaneously emerge. Integration of rheology, thermal effects, and other microphysical processes with rate-and-state friction may yield further insight into the phenomenology of slow slip.The dynamics of fault slip at subduction zones can assume a wide range of behaviors. A continuum of slip modes that includes fast earthquakes, slow-slip events, and stable creep determines seismic hazards 1,2 . Along the megathrust, earthquakes, very low frequency earthquakes, and tsunami earthquakes are typically found updip of the continental Mohorovicic (Moho) discontinuity. In contrast, slow-slip events are often found close to or below the continental Moho depth at many subduction zones around the circum-Pacific seismic belt 3 , even though some happen at shallow depth, notably in New Zealand 4-6 and Costa Rica 7,8 . Slow-slip events at subduction zones worldwide often embody similar, characteristic features [9][10][11][12][13] . In particular, we observe small stress drops in the range 10-200 kPa, short recurrence times of a few months to a few years, and sometimes more regular periodicity than for earthquakes 14 . Some characteristics of slow-slip events can be explained within the context of rate-and-state friction 15,16 with conditionally stable behavior [17][18][19][20][21] . Runaway frictional instabilities require a critical size for nucleation that depends on the frictional parameters and the effective confining pressure. For sufficiently small velocity-weakening asperities, only creep spontaneously occurs. Slow-slip events emerge spontaneously when the asperity size is commensurate to critical nucleation size 22 . As slow-slip events are now found close to universally at subduction zones [23][24][25][26][27][28] , it is unrealistic to expect the same combination of parameters across widely distant regions (Fig. 1A). Several authors developed and investigated other friction l...