Slow vertical saccades in the frontotemporal dementia with motor neuron disease

Moon, Sy; Lee, B. H.; Seo, Sang Won; Kang, Sung-Jin; Na, D. L.

doi:10.1007/s00415-008-0890-y

Cited by 15 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Supranuclear gaze palsy and variably decreased saccade velocity have been reported in autopsy confirmed ALS 34–35 and clinically-diagnosed FTD-ALS; 36 however, we found no evidence of decreased saccade velocity in the six pathologically confirmed FTLD-ALS subjects studied here. Since saccade abnormalities in ALS have been closely associated with bulbar-onset cases, 37 the lack of such abnormalities in our subjects may reflect the fact that none of our FTLD-ALS cases had bulbar-onset disease.…”

Section: Commentcontrasting

confidence: 77%

Saccade Abnormalities in Autopsy-Confirmed Frontotemporal Lobar Degeneration and Alzheimer Disease

Garbutt¹

2012

Arch Neurol

View full text Add to dashboard Cite

Section: Commentcontrasting

confidence: 77%

Saccade Abnormalities in Autopsy-Confirmed Frontotemporal Lobar Degeneration and Alzheimer Disease

Garbutt¹

2012

Arch Neurol

View full text Add to dashboard Cite

“…109 In a smaller size study of FTD associated with motor neuron disease (MND), and in whom gross ocular abnormalities were present, slowing of both vertical and horizontal saccades was observed. 110 In a much larger study (n > 100) comparing various forms of FTD and other related disorders, an overlap was observed between most groups, but only in FTD were there spontaneous self-correcting anti-saccade errors. 111 In addition, mutual gaze ('eye contact'), which is important in social interactions, is impaired in a number of dementias including FTD, but was preserved in AD subjects.…”

Section: Eye Movementsmentioning

confidence: 96%

Oculo‐visual changes and clinical considerations affecting older patients with dementia

Armstrong

Kergoat

2015

Ophthalmic Physiologic Optic

View full text Add to dashboard Cite

Purpose Dementia is associated with various alterations of the eye and visual function. Over 60% of cases are attributable to Alzheimer's disease, a significant proportion of the remainder to vascular dementia or dementia with Lewy bodies, while frontotemporal dementia, and Parkinson's disease dementia are less common. This review describes the oculo‐visual problems of these five dementias and the pathological changes which may explain these symptoms. It further discusses clinical considerations to help the clinician care for older patients affected by dementia. Recent findings Visual problems in dementia include loss of visual acuity, defects in colour vision and visual masking tests, changes in pupillary response to mydriatics, defects in fixation and smooth and saccadic eye movements, changes in contrast sensitivity function and visual evoked potentials, and disturbance of complex visual functions such as in reading ability, visuospatial function, and the naming and identification of objects. Pathological changes have also been reported affecting the crystalline lens, retina, optic nerve, and visual cortex. Clinically, issues such as cataract surgery, correcting the refractive error, quality of life, falls, visual impairment and eye care for dementia have been addressed. Summary Many visual changes occur across dementias, are controversial, often based on limited patient numbers, and no single feature can be regarded as diagnostic of any specific dementia. Nevertheless, visual hallucinations may be more characteristic of dementia with Lewy bodies and Parkinson's disease dementia than Alzheimer's disease or frontotemporal dementia. Differences in saccadic eye movement dysfunction may also help to distinguish Alzheimer's disease from frontotemporal dementia and Parkinson's disease dementia from dementia with Lewy bodies. Eye care professionals need to keep informed of the growing literature in vision/dementia, be attentive to signs and symptoms suggestive of cognitive impairment, and be able to adapt their practice and clinical interventions to best serve patients with dementia.

show abstract

“…Different clinical types of ALS have come to be recognized in recent years, including the PSP variant of ALS . Although this disease entity is still a subject of debate, supranuclear gaze palsy accompanied by slow saccades has been reported in ALS patients, especially in those with cognitive impairment or early onset bulbar symptoms . Moon et al .…”

Section: Discussionmentioning

confidence: 99%

“…18 Although this disease entity is still a subject of debate, supranuclear gaze palsy accompanied by slow saccades has been reported in ALS patients, especially in those with cognitive impairment or early onset bulbar symptoms. 3,[18][19][20][21][22][23] Moon et al showed that some patients with MND with frontotemporal dementia present with slow vertical saccades, and argued that some brainstem lesions, such as midbrain and rostral interstitial nucleus of the medial longitudinal fasciculus, could have resulted in their slow vertical saccades. 3 Furthermore, PSP-like changes, such as neuronal cell loss in the rostral interstitial nucleus of the medial longitudinal fasciculus and the substantia nigra, have been pathologically confirmed in a MND patient with slow saccades, although no tau pathology was evident.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Motor neuron disease with saccadic abnormalities similar to progressive supranuclear palsy

Tokushige

Terao

Matsuda

et al. 2016

Neurology & Clinical Neurosc

View full text Add to dashboard Cite

Background: In recent years, a variety of clinical types of amyotrophic lateral sclerosis have come to be recognized. As some patients present with oculomotor abnormalities both clinically and pathologically, the progressive supranuclear palsy variant of amyotrophic lateral sclerosis has been proposed. Aim: To describe atypical cases of motor neuron disease with abnormal extraocular movements mimicking progressive supranuclear palsy. Methods: We present three motor neuron disease patients with slow saccades, who were aged 57, 63 and 62 years. Neurological examinations found vertical gaze palsy in two patients. The two patients who presented extrapyramidal signs were regarded as motor neuron disease with parkinsonism, whereas the other was diagnosed with amyotrophic lateral sclerosis. Their saccades were investigated by visually-guided saccade and memory-guided saccade tasks, and were compared with those of 14 age-matched normal participants (60.3 AE 1.9 years). Results: In all these patients, the visually-guided saccade latencies were significantly prolonged compared with normal participants, whereas the memory-guided saccade latencies were not. The velocity and amplitude of saccades of the patients were significantly reduced in visually-guided saccade and memory-guided saccade in comparison with normal participants. Conclusion: The patterns of saccadic abnormalities in the patients were similar to those of progressive supranuclear palsy patients, suggesting that some patients with motor neuron disease show saccade abnormalities similar to those of progressive supranuclear palsy patients from the clinical and physiological perspective. Motor neuron disease with slow saccades and parkinsonism, as reported here, suggest the existence of progressive supranuclear palsy-variant amyotrophic lateral sclerosis.

show abstract

Slow vertical saccades in the frontotemporal dementia with motor neuron disease

Cited by 15 publications

References 33 publications

Saccade Abnormalities in Autopsy-Confirmed Frontotemporal Lobar Degeneration and Alzheimer Disease

Saccade Abnormalities in Autopsy-Confirmed Frontotemporal Lobar Degeneration and Alzheimer Disease

Oculo‐visual changes and clinical considerations affecting older patients with dementia

Motor neuron disease with saccadic abnormalities similar to progressive supranuclear palsy

Contact Info

Product

Resources

About