Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

Abstract

See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.Sleep deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote amyloid plaques and other downstream Alzheimer's disease pathologies including tauopathy or inflammation. To date, studies have not examined which aspect of sleep modulates amyloid-β or other Alzheimer's disease biomarkers. Seventeen healthy adults (age 35-65 years) without sleep disorders underwent 5-14 days of actigraphy, followed by slow wave activity disruption during polysomnogram, and cerebrospinal fluid collection the following morning for measurement of amyloid-β, tau, total protein, YKL-40, and hypocretin. Data were compared to an identical protocol, with a sham condition during polysomnogram. Specific disruption of slow wave activity correlated with an increase in amyloid-β40 (r = 0.610, P = 0.009). This effect was specific for slow wave activity, and not for sleep duration or efficiency. This effect was also specific to amyloid-β, and not total protein, tau, YKL-40, or hypocretin. Additionally, worse home sleep quality, as measured by sleep efficiency by actigraphy in the six nights preceding lumbar punctures, was associated with higher tau (r = 0.543, P = 0.045). Slow wave activity disruption increases amyloid-β levels acutely, and poorer sleep quality over several days increases tau. These effects are specific to neuronally-derived proteins, which suggests they are likely driven by changes in neuronal activity during disrupted sleep.

Slow‐wave sleep and motor progression in Parkinson disease

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Obstructive sleep apnea treatment, slow wave activity, and amyloid‐β

“…8 Individuals (n = 4) with abnormally low Aβ42 levels (<608 pg/ml) indicating amyloid plaques were excluded from analyses of Aβ40 or Aβ42. 6,8 Statistical Analysis (Table 1). 6,8 Statistical Analysis (Table 1).…”

“…We previously showed that OSA may impair Aβ clearance and affect the relationship between slow wave activity (SWA) and Aβ. 4,5 Preliminary studies suggest slow wave activity (SWA) may modulate soluble Aβ; selective SWA deprivation increases Aβ, 6 whereas partial sleep deprivation with preserved SWA does not affect Aβ. OSA treatment increased SWA, and SWA was significantly correlated with lower Aβ after treatment.…”

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