Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model

Casanova-Carvajal, Oscar; Urbano-Bojorge, Ana Lorena; Ramos, Milagros; Olmedo, José Javier Serrano; Martı́nez-Murillo, Ricardo

doi:10.1088/1361-6528/ab2164

Cited by 11 publications

(10 citation statements)

References 27 publications

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“…The gold nanorods decorated with CD133 antibody, when irradiated with laser beam, resulted in the regression of tumor. Gold nanorods along with a continuous laser wave of 808 nm proved an optimistic therapy of glioblastoma multiforme by the induction of hyperthermia [26].…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections

et al. 2021

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The blood–brain barrier (BBB) is the protective sheath around the brain that protects the sensitive microenvironments of the brain. However, certain pathogens, viruses, and bacteria disrupt the endothelial barrier and cause infection and hence inflammation in meninges. Macromolecular therapeutics are unable to cross the tight junctions, thereby limiting their bioavailability in the brain. Recently, nanotechnology has brought a revolution in the field of drug delivery in brain infections. The nanostructures have high targeting accuracy and specificity to the receptors in the case of active targeting, which have made them the ideal cargoes to permeate across the BBB. In addition, nanomaterials with biomimetic functions have been introduced to efficiently cross the BBB to be engulfed by the pathogens. This review focuses on the nanotechnology-based drug delivery approaches for exploration in brain infections, including meningitis. Viruses, bacteria, fungi, or, rarely, protozoa or parasites may be the cause of brain infections. Moreover, inflammation of the meninges, called meningitis, is presently diagnosed using laboratory and imaging tests. Despite attempts to improve diagnostic instruments for brain infections and meningitis, due to its complicated and multidimensional nature and lack of successful diagnosis, meningitis appears almost untreatable. Potential for overcoming the difficulties and limitations related to conventional diagnostics has been shown by nanoparticles (NPs). Nanomedicine now offers new methods and perspectives to improve our knowledge of meningitis and can potentially give meningitis patients new hope. Here, we review traditional diagnosis tools and key nanoparticles (Au-NPs, graphene, carbon nanotubes (CNTs), QDs, etc.) for early diagnosis of brain infections and meningitis.

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Section: Metal Nanoparticlesmentioning

confidence: 99%

Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections

et al. 2021

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“…As observed in the CT-2A experiments, higher cell viability requires shorter exposure time and lower-power exposure, which is in contrast with low cell viability that requires longer exposure time and higher-power exposure. Notice that MC3T3-E1 cells were more resistant to exposure that CT-2A cells, and also that cancer cells are more sensitive to heat than healthy cells [25]. SMSs Group, Orange Bar.…”

Section: Mc3t3-e1mentioning

confidence: 99%

“…In this study, SMSs were used to determine variations in the toxicity rate after conducting in vitro cytotoxicity tests at 24 h [ 24 ]. Likewise, experiments were carried out to prove silica’s biocompatibility when mixing with biological cells, such as the CT-2A and the MC3T3-E1 cell lines established from C57BL/6 mice [ 20 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

The Use of Silica Microparticles to Improve the Efficiency of Optical Hyperthermia (OH)

Casanova-Carvajal

Zeinoun

Urbano-Bojorge

et al. 2021

IJMS

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Although optical hyperthermia could be a promising anticancer therapy, the need for high concentrations of light-absorbing metal nanoparticles and high-intensity lasers, or large exposure times, could discourage its use due to the toxicity that they could imply. In this article, we explore a possible role of silica microparticles that have high biocompatibility and that scatter light, when used in combination with conventional nanoparticles, to reduce those high concentrations of particles and/or those intense laser beams, in order to improve the biocompatibility of the overall procedure. Our underlying hypothesis is that the scattering of light caused by the microparticles would increase the optical density of the irradiated volume due to the production of multiple reflections of the incident light: the nanoparticles present in the same volume would absorb more energy from the laser than without the presence of silica particles, resulting either in higher heat production or in the need for less laser power or absorbing particles for the same required temperature rise. Testing this new optical hyperthermia procedure, based on the use of a mixture of silica and metallic particles, we have measured cell mortality in vitro experiments with murine glioma (CT-2A) and mouse osteoblastic (MC3T3-E1) cell lines. We have used gold nanorods (GNRs) that absorb light with a wavelength of 808 nm, which are conventional in optical hyperthermia, and silica microparticles spheres (hereinafter referred to as SMSs) with a diameter size to scatter the light of this wavelength. The obtained results confirm our initial hypothesis, because a high mortality rate is achieved with reduced concentrations of GNR. We found a difference in mortality between CT2A cancer cells and cells considered non-cancer MC3T3, maintaining the same conditions, which gives indications that this technique possibly improves the efficiency in the cell survival. This might be related with differences in the proliferation rate. Since the experiments were carried out in the 2D dimensions of the Petri dishes, due to sedimentation of the silica particles at the bottom, whilst light scattering is a 3D phenomenon, a large amount of the energy provided by the laser escapes outside the medium. Therefore, better results might be expected when applying this methodology in tissues, which are 3D structures, where the multiple reflections of light we believe will produce higher optical density in comparison to the conventional case of no using scattering particles. Accordingly, further studies deserve to be carried out in this line of work in order to improve the optical hyperthermia technique.

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“…These characteristics reflect their heterogeneity on their electron number and configuration which in turn determine their light absorption and heat emission rates [208]. PTAs with high NIR absorbance rate that have displayed antineoplastic effects in GBM experimental models include carbon nanotubes [207,[212][213][214], carbon nanodots [215], gold nanorods [209,216,217], gold nanoshells [217,218], gold nanospheres [219], gold nanostars [52,220], silk fibroin nanoparticles [221], silicon based nanoparticles [222] and iron-oxide carbon core-shell nanoparticles [210].…”

Section: Nanoparticle-mediated Pttmentioning

confidence: 99%

“…Peptide 22 polypeptide conjugation facilitated crossing of the BBB and delivery of the PTAs to the tumor in an orthotopic rodent glioma model [226]. CD133 monoclonal antibodies have been conjugated with carbon and gold PTAs for the targeting of CD133 þ glioma stem cells resulting in a profound decrease of tumor growth in both flank and orthotopic rodent glioma models [214,216]. Others have studied vascular endothelial growth factor (VEGF)-conjugated PTAs for targeting of the tumor vasculature in orthotopic GBM models [227].…”

Section: Targeted Delivery Of Ptasmentioning

confidence: 99%

Hyperthermia treatment advances for brain tumors

Skandalakis

Rivera

Rizea

et al. 2020

International Journal of Hyperthermia

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Hyperthermia therapy (HT) of cancer is a well-known treatment approach. With the advent of new technologies, HT approaches are now important for the treatment of brain tumors. We review current clinical applications of HT in neuro-oncology and ongoing preclinical research aiming to advance HT approaches to clinical practice. Laser interstitial thermal therapy (LITT) is currently the most widely utilized thermal ablation approach in clinical practice mainly for the treatment of recurrent or deepseated tumors in the brain. Magnetic hyperthermia therapy (MHT), which relies on the use of magnetic nanoparticles (MNPs) and alternating magnetic fields (AMFs), is a new quite promising HT treatment approach for brain tumors. Initial MHT clinical studies in combination with fractionated radiation therapy (RT) in patients have been completed in Europe with encouraging results. Another combination treatment with HT that warrants further investigation is immunotherapy. HT approaches for brain tumors will continue to a play an important role in neuro-oncology.

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Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model

Cited by 11 publications

References 27 publications

Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections

Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections

The Use of Silica Microparticles to Improve the Efficiency of Optical Hyperthermia (OH)

Hyperthermia treatment advances for brain tumors

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