Ingestible electronic
systems that are capable of embedded sensing,
particularly within the gastrointestinal (GI) tract and its accessory
organs, have the potential to screen for diseases that are difficult
if not impossible to detect at an early stage using other means. Furthermore,
these devices have the potential to (1) reduce labor and facility
costs for a variety of procedures, (2) promote research for discovering
new biomarker targets for associated pathologies, (3) promote the
development of autonomous or semiautonomous diagnostic aids for consumers,
and (4) provide a foundation for epithelially targeted therapeutic
interventions. These technological advances have the potential to
make disease surveillance and treatment far more effective for a variety
of conditions, allowing patients to lead longer and more productive
lives. This review will examine the conventional techniques, as well
as ingestible sensors and sensing systems that are currently under
development for use in disease screening and diagnosis for GI disorders.
Design considerations, fabrication, and applications will be discussed.