2023
DOI: 10.1002/cncr.35058
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SMAD4 loss predicts worse overall and distant metastasis‐free survival in patients with resected pancreatic adenocarcinoma

Emily J. Anstadt,
Ruben Carmona,
Eva Berlin
et al.

Abstract: BackgroundIn select patients, pancreatic adenocarcinoma remains a local disease, yet there are no validated biomarkers to predict this behavior and who may benefit from aggressive local treatments. This study sought to determine if SMAD4 (mothers against decapentaplegic homolog 4) messenger RNA–sequencing (RNA‐seq) expression is a robust method for predicting overall survival (OS) and distant metastasis‐free survival (DMFS) in patients with resected pancreatic adenocarcinoma.MethodsUtilizing The Cancer Genome … Show more

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