Small airway obstruction in allergic rhinitis†*

Grossman, Jay; Putnam, Jerome S.

doi:10.1016/s0091-6749(75)80007-8

Cited by 29 publications

(6 citation statements)

References 13 publications

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“…This has been suggested by the frequent occurrence of attacks of wheezing in subjects with hay fever at times of heavy pollen exposure, and by the uncovering of abnormal bronchial reactivity following the administration of acetylcholine (Vondra et al, 1971;Ionescu, 1973;Grossman and Putnam, 1975). In our study, reversible abnormality of airway function has been demonstrated in subjects with hay fever who exhibit normal pulmonary function by conventional testing.…”

Section: Resultssupporting

confidence: 72%

“…Previous investigators (Vondra et al, 1971;Ionescu, 1973;Grossman and Putnam, 1975) have shown that bronchoconstriction may be induced in subjects with hay fever by the administration of acetylcholine or methacholine, a significant fall in one-second forced expiratory volume (FEV,) and maximal mid expiratory flow (MMF) occurring in 20 to 50% of cases. Conventional tests of lung function in patients with hay fever are usually normal (May and Kotowska, 1965).…”

mentioning

confidence: 99%

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Abnormalities of lung function in hay fever.

Morgan¹,

Hall²

1976

Thorax

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. (1976). Thorax, 31,[80][81][82][83][84][85][86]. Abnormalities of lung function in hay fever. Twenty subjects with symptoms of hay fever were studied to see whether abnormalities could be detected in the function of small airways. The investigations included dynamic compliance at varying respiratory frequencies, closing capacity, residual volume, transfer factor, and maximal expiratory flow-volume curves. The tests were repeated in the winter when symptoms had resolved.Frequency dependence of compliance was found in eight subjects with symptoms (40%), closing capacities being abnormal in only two instances. Conventional pulmonary function tests, including expiratory flow rates at mid vital capacity, were within the predicted range for all subjects. When tests were repeated in the winter, frequency dependence of compliance was no longer present in subjects whose symptoms had resolved.The study suggests that reversible small airway abnormalities are present in a significant proportion of subjects with symptoms of hay fever and that such abnormalities are best detected by the measurement of dynamic compliance at varying respiratory frequencies.

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Section: Resultssupporting

confidence: 72%

mentioning

confidence: 99%

Abnormalities of lung function in hay fever.

Morgan¹,

Hall²

1976

Thorax

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“…The reduction of lung function in patients with allergic rhinitis has been documented previously [24,25). The fact that common cold and lowered FEV 1 were highly related, independent of smoking habits, is consistent with our findings in the same population in 1980 [20).…”

Section: Discussionsupporting

confidence: 92%

Relationship of upper airways disorders to FEV1 and bronchial hyperresponsiveness in an epidemiological study

Annesi¹,

Oryszczyn²,

Neukirch³

et al. 1992

Eur Respir J

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Associations of upper airways disorders (UAD) with forced expiratory volume in one second (FEV1) and bronchial methacholine response were studied, taking smoking habits into account. We used epidemiological data drawn from a population of 324 men, aged 27-58 yrs. Lower FEV1 level was related to hay fever (p = 0.01), usual (p = 0.01) and chronic (p = 0.02) rhinitis and common cold on the day of examination (p = 0.04). Allowance for the major potential confounding factor, tobacco smoking, showed similar results. Bronchial methacholine response was heightened in men reporting hay fever compared to those without (p = 0.01) but also in men reporting chronic rhinitis (p = 0.06), a group which did not exhibit skin prick test positivity more often than other subjects. Exclusion of asthmatics and taking into account smoking and skin prick test positivity yielded mostly similar results. Our data support the hypothesis of an association between lung impairment, as assessed by lower FEV1 and bronchial hyperresponsiveness to methacholine, and different types of UAD, allergic or not.

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“…Atopy is known to play an important role in asthma and allergic rhinitis (22), is a risk factor for sinusitis (23,24), and is thought to be a risk factor for otitis media with effusion, although the data are less compelling (25,26). A variety of mechanisms have been proposed linking sinusitis with asthma including the production of mediators of bronchoconstriction in inflamed sinuses (27,28).…”

Section: Introductionmentioning

confidence: 99%

Health Care Utilization and Cost in Children with Asthma and Selected Comorbidities

2001

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Children with asthma use significantly more health services than other children, yet the majority of their health care costs are for nonasthma services. The objective of this study was to measure the impact of asthma and specific upper respiratory comorbidities on the use and cost of health care by children. A population-based historical cohort study from January 1, 1992 to December 31, 1992 was conducted. Multiple visits for otitis media, sinusitis, and allergic rhinitis were considered comorbidities. The outcome measures were nonurgent outpatient care, pharmacy fills, urgent care visits, and hospital care along with the associated total costs. Children between ages 1 and 17 years were studied (n = 71,818). Children with asthma were more likely than children without asthma to have a comorbidity (26% vs. 9%). Children with multiple visits for otitis media, sinusitis, and allergic rhinitis were 1.8, 4, and 12 times more likely, respectively, to have a diagnosis of asthma in the same year. Children with asthma had a 47% probability of being in the highest total cost quintile compared to a 29% likelihood once adjusted for comorbidities. Visits for otitis media, sinusitis, and particularly allergic rhinitis appear to be overrepresented in children with asthma and contribute to their high utilization rate. Once a high-risk cohort is identified, the needs of those children can be addressed through targeted, organized systems of care that may include guidelines or other disease management strategies.

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Small airway obstruction in allergic rhinitis†*

Cited by 29 publications

References 13 publications

Abnormalities of lung function in hay fever.

Abnormalities of lung function in hay fever.

Relationship of upper airways disorders to FEV1 and bronchial hyperresponsiveness in an epidemiological study

Health Care Utilization and Cost in Children with Asthma and Selected Comorbidities

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