“…It appears that cholesterol can promote or inhibit Aβ aggregation at the membrane, affect the secondary structure of amyloid and its ability to penetrate the bilayer (Williams and Serpell, 2011 ; Yu and Zheng, 2012 ). Many factors influence the outcome of the interaction: the molar ratio of lipid/cholesterol in the cell membrane, the presence of anionic lipids, SM, and gangliosides (especially GM1), lipid membrane ordering and fluidity, the amyloid species, the extent of Aβ oligomerization, the pH, the presence of other proteins or amyloid membrane receptors (Yu and Zheng, 2012 ; Meleleo et al, 2013 ; Dies et al, 2014 ; Amaro et al, 2016 ; West et al, 2017 ; Owen et al, 2018 ; Carrotta et al, 2021 ; Smeralda et al, 2021 ; Wiatrak et al, 2021 ). Moreover, physical parameters such as macromolecular crowding or vesicle size and membrane curvature play a role in Aβ–membrane interaction (Hirai et al, 2018 ; Terakawa et al, 2018 ).…”