Small-artery-mimicking multi-layered 3D co-culture in a self-folding porous graphene-based film

Sakai, Koji; Miura, Shigenori; Teshima, Tetsuhiko F.; Goto, Toichiro; Takeuchi, Shoji; Yamaguchi, Masumi

doi:10.1039/d3nh00304c

Nanoscale Horiz.

2023

DOI: 10.1039/d3nh00304c

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Small-artery-mimicking multi-layered 3D co-culture in a self-folding porous graphene-based film

Koji Sakai,

Shigenori Miura,

Tetsuhiko F. Teshima

et al.

Abstract: In vitro vessel-mimicking models have been spotlighted as a powerful tool for investigating cellular behaviours in vascular development and diseases. However, it is still challenging to create micro-scale tubular tissues...

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2024

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Toward Functional Biointerfaces with Origami‐on‐a‐Chip

Ingar Romero,

Jin,

Parker

et al. 2024

Advanced Intelligent Systems

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Studying the behavior of electroactive cells, such as firing dynamics and chemical secretion, is crucial for developing human disease models and therapeutics. Following the recent advances in cell culture technology, traditional monolayers are optimized to resemble more 3D, organ‐like structures. The biological and electrochemical complexity of these structures requires devices with adaptive shapes and novel features, such as precise electrophysiological mapping and stimulation in the case of brain‐ and heart‐derived tissues. However, conventional organ‐on‐chip platforms often fall short, as they do not recreate the native environment of the cells and lack the functional interfaces necessary for long‐term monitoring. Origami‐on‐a‐chip platforms offer a solution for this problem, as they can flexibly adapt to the structure of the desired biological sample and can be integrated with functional components enabled by chosen materials. In this review, the evolution of origami‐on‐a‐chip biointerfaces is discussed, emphasizing folding stimuli, materials, and critical findings. In the prospects, microfluidic integration, functional tissue engineering scaffolds, and multi‐organoid networks are included, allowing patient‐specific diagnoses and therapies through computational and in vitro disease modeling.

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Toward Functional Biointerfaces with Origami‐on‐a‐Chip

Ingar Romero,

Jin,

Parker

et al. 2024

Advanced Intelligent Systems

View full text Add to dashboard Cite

show abstract

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Small-artery-mimicking multi-layered 3D co-culture in a self-folding porous graphene-based film

Abstract: In vitro vessel-mimicking models have been spotlighted as a powerful tool for investigating cellular behaviours in vascular development and diseases. However, it is still challenging to create micro-scale tubular tissues...

Cited by 1 publication

References 34 publications

Toward Functional Biointerfaces with Origami‐on‐a‐Chip

Toward Functional Biointerfaces with Origami‐on‐a‐Chip

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