Small Bowel Adenocarcinoma Complicating Coeliac Disease: A Report of Three Cases and the Literature Review

Benhammane, Hafida; Mrabet, F.Z.; Serhouchni, Karima Idrissi; Yousfi, Mounia El; Charif, Ilias; Toughray, Imane; Mellas, Naoufal; Amarti, Afaf; Maazaz, Khalid; Ibrahimi, Sidi Adil; Mesbahi, Omar El

doi:10.1155/2012/935183

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…Since most intestinal adenocarcinomas are diagnosed in the advanced stages of the disease (74% are diagnosed at stage III/IV), its prognosis is poor. Overall, 5-year survival is around 15–42% 12. As histopathological examination did not reveal any regional lymph node involvement in the present case, postoperative adjuvant chemotherapy was not administered.…”

Section: Discussionmentioning

confidence: 65%

Intestinal invagination secondary to intestinal adenocarcinoma in coeliac disease

et al. 2015

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Invagination is defined as a medical condition in which a part of the gastrointestinal tract has entered into another section. Intestinal invagination is a rare clinical entity among adults and there is an underlying structural lesion in most of the cases. Coeliac disease is considered as a risk factor for intestinal invagination, because of the associated inflammatory processes and motility disorders as well as the increased risk for secondary malignancies. We report a case of intestinal invagination secondary to intestinal adenocarcinoma in a woman with coeliac disease, whose adherence to a gluten-free diet was poor.

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Section: Discussionmentioning

confidence: 65%

Intestinal invagination secondary to intestinal adenocarcinoma in coeliac disease

et al. 2015

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“…In contrast to small bowel adenocarcinoma in general, where the duodenum is affected most frequently, carcinomas tend to develop in the jejunum in most cases of CD patients, which corresponds with our case. Vomiting, anemia, weight loss, intestinal bleeding, abdominal mass, and perforation are the most frequent symptoms (17). Unfortunately, a diagnosis is usually made in the advanced stages of the disease (74% in stage III-IV) (14).…”

Section: Discussionmentioning

confidence: 99%

Adenokarcinom tenkého střeva diagnostikovaný pomocí video kapslové endoskopie u pacientky s celiakií: kazuistika a přehled literatury

Packová¹,

Kunovský²,

Eid³

et al. 2020

Vnitř Lék

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Celiac disease is an immune mediated entheropathy triggered by gluten in genetically predisposed individuals. Patients with celiac disease are at a higher risk of gastrointestinal malignancies. Diagnosis at an advance stage is one of the factors of an unfavorable prognosis of these complications. Our patient is a woman who was diagnosed with celiac disease at 53 years of age. After two years on a gluten-free diet she developed sideropenic anemia. No source of bleeding was found on the esophagogastroduodenoscopy or colonoscopy. Video capsule endoscopy revealed exulcerated bleeding stenosis in the jejunum, in front of which the capsule lodged. There were no signs of infiltration on simultaneous CT enterography. The patient was operated on and the infiltration of the jejunum was resected. The specimen was evaluated by a histopathologist as a moderately differentiated adenocarcinoma. Due to the risk factors, the patient received adjuvant chemotherapy. The knowledge of the malignant complications of celiac disease, their risk factors and the possibilities of modern enteroscopic methods could help in the early diagnosis and improvement of the prognosis of these diseases. Due to a lack of data and an absence of guidelines, treatment of a small bowel adenocarcinoma is based on an expert agreement and guidelines for colon cancer. Surgical treatment is the only potentially curative option. For stage II with risk factors and stage III adjuvant chemotherapy should be considered.

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“…Thirteen percent of small bowel adenocarcinomas have been shown to be associated with celiac disease [ 14 ]. Cases of small bowel adenocarcinoma in patients with celiac disease have been previously reported [ 15 – 17 ].…”

Section: Discussionmentioning

confidence: 99%

Small Bowel Adenocarcinoma as the Cause of Gastrointestinal Bleeding in Celiac Disease: A Rare Malignancy in a Common Disease

Fallah

Afari

Córdova

et al. 2015

Case Reports in Oncological Medicine

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Introduction. Celiac disease is associated with an increased risk of small bowel malignancies, particularly lymphoma. Its association with small bowel carcinoma is less known. Case Description. We report a case of an 89-year-old woman with celiac disease who experienced recurrent episodes of gastrointestinal bleeding and was ultimately found to have adenocarcinoma of the small intestine. Discussion and Evaluation. Diagnosis of small bowel adenocarcinoma is often delayed because of the need for specialized modalities, which are often deferred in the inpatient setting. Although resection is the modality of choice for small bowel tumors, a majority is either locally advanced or metastatic at diagnosis, and even localized cancers have worse prognosis than stage-matched colorectal tumors. The role of adjuvant chemotherapy is uncertain, but it is often offered extrapolating data from other gastrointestinal cancers. Small bowel carcinomas occurring in the context of celiac disease appear to be associated with higher rates of microsatellite instability than sporadic tumors, although other specific genomic abnormalities and mechanisms of carcinogenesis in celiac disease remain unknown. Conclusion. Recurrent episodes of gastrointestinal bleeding in a patient with celiac disease should prompt an early evaluation of the small bowel to assure timely diagnosis of carcinoma at an early curable stage.

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Small Bowel Adenocarcinoma Complicating Coeliac Disease: A Report of Three Cases and the Literature Review

Cited by 7 publications

References 13 publications

Intestinal invagination secondary to intestinal adenocarcinoma in coeliac disease

Intestinal invagination secondary to intestinal adenocarcinoma in coeliac disease

Adenokarcinom tenkého střeva diagnostikovaný pomocí video kapslové endoskopie u pacientky s celiakií: kazuistika a přehled literatury

Small Bowel Adenocarcinoma as the Cause of Gastrointestinal Bleeding in Celiac Disease: A Rare Malignancy in a Common Disease

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