2011
DOI: 10.1007/s11605-011-1441-x
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Small Bowel Adenocarcinoma in Crohn’s Disease

Abstract: A comparison to our previous series reveals similar clinical characteristics and a high rate of node-positive cancer at diagnosis. Our findings also confirm two important clinical indicators of malignancy: recrudescent symptoms after long periods of relative quiescence and small bowel obstruction that is refractory to medical therapy.

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Cited by 44 publications
(56 citation statements)
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References 15 publications
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“…These warrant attention without delay. Compared to adenocarcinoma arising de novo, adenocarcinoma in CD present at a median age of 48 years, is more common in males, ileum as most common site and mucinous signet ring cell is more frequently seen [57] . Early diagnosis and small bowel resection offers the best success for long term survival.…”
Section: Crohn's Diseasementioning
confidence: 98%
“…These warrant attention without delay. Compared to adenocarcinoma arising de novo, adenocarcinoma in CD present at a median age of 48 years, is more common in males, ileum as most common site and mucinous signet ring cell is more frequently seen [57] . Early diagnosis and small bowel resection offers the best success for long term survival.…”
Section: Crohn's Diseasementioning
confidence: 98%
“…Adenocarcinoma in Crohn disease is a poorly differentiated neoplasm in more than 50% of the cases and is associated with a worse prognosis than sporadic small bowel adenocarcinoma (Widmar et al, 2011). This may be explained in part by a delayed diagnosis in CD patients, since one third of small bowel adenocarcinomas are stage IV tumors at the time of diagnosis (Widmar et al, 2011).…”
Section: Clinical and Histological Featuresmentioning
confidence: 99%
“…8 Another important consideration is that an increased risk of cancer is reported in patients with CD who have bowel segments bypassed by internal fistulae. 9 A recent metaanalysis 10 demonstrated an increased risk of small bowel, colonic, and extraintestinal carcinoma and of lymphoma in patients with CD, which may be accounted for in part by this phenomenon.…”
mentioning
confidence: 99%