Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide

Kwasniewski, Fábio Henrique; Landgraf, Richardt Gama; Jancar, Sônia

doi:10.1016/j.intimp.2007.10.021

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…We found neutrophils inside microvessels as well as in the surrounding tissue as soon as 15 min after Tbv or Tsv injection, and we believe that such cells may be important in the genesis of the edema induced by Tbv and Tsv. Although 15 min could be considered a short time to provide injury mediated by neutrophils, we showed before, in a different model, that neutrophils are probably involved in organ injury in rats sooner as 15 min [16]. A role for neutrophils in injury induced by scorpion venoms was suggested before by D'Suze et al [17], but in a model of lung edema induced by Tsv, inhibition of leukocyte migration was probably not correlated to lung injury as also was not able to reduce the mortality [18].…”

Section: Discussionmentioning

confidence: 90%

Edematogenic Activity of Scorpion Venoms from the Buthidae Family and the Role of Platelet-Activating Factor and Nitric Oxide in Paw Edema Induced by Tityus Venoms

et al. 2008

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We compared the edematogenic activity of venoms of scorpions from the Buthidae family, Tityus bahiensis (Tbv), Tityus serrulatus (Tsv) and Rhopalurus rochai (Rrv). Three doses (20, 40 and 80 microg/kg sc) of each venom were administrated in hind paw of mice and edema was measured from 5 min to 24 h. Tbv and Tsv both induced edema of rapid onset (135% of increase at 15 min); Rrv induced only a mild edema (40% of increase). We then investigated the involvement of platelet-activating factor (PAF) and endogenous nitric oxide (NO) in Tbv and Tsv-induced paw edema. Pretreatment of mice with a PAF antagonist (WEB-2170) inhibited Tsv but not Tbv-induced edema. Pretreatment with a non selective inhibitor of NO-synthases (L: -NAME) inhibited or increased the edema depending on the dose and the time the edema was measured. In conclusion, the venoms from Tityus are stronger inducers of edema than the venom from the Rhopalurus scorpion. The venoms of Tityus species are similar in potency and time-course edema development. PAF is involved in the edema induced only by Tsv.

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Section: Discussionmentioning

confidence: 90%

Edematogenic Activity of Scorpion Venoms from the Buthidae Family and the Role of Platelet-Activating Factor and Nitric Oxide in Paw Edema Induced by Tityus Venoms

et al. 2008

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“…41 Interestingly, our data showed Arg alleviated the increase of the number of mast cells induced by LPS. Similarly, Kwasniewski et al 42 indicated that Arg reduced the intestinal hermorrhagic lesions associated with allergy, which was triggered by mast cells and platelet-activating factor. In the present study, Arg might have stabilized the mast cells and alleviated the effect of LPS-induced mast cell increase.…”

Section: Discussionmentioning

confidence: 93%

Effect of l-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge

et al. 2012

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The effects of l-arginine (Arg) supplementation on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge were evaluated. Twenty-four weaned pigs were allotted to four treatments including: (i) non-challenged control; (ii) LPS-challenged control; (iii) LPS + 0.5% Arg; and (iv) LPS + 1.0% Arg. On d 16, pigs in the LPS, LPS + 0.5% Arg and LPS + 1.0% Arg groups were challenged by injection with 100 µg/kg of body mass LPS, whereas the control group were given sterile saline. At 48 h post-challenge, all pigs were sacrificed for evaluation of small intestinal morphology and mucosal immune barrier function. In the jejunum and ileum, LPS caused villous atrophy and intestinal morphology disruption, whereas 0.5% or 1.0% Arg supplementation mitigated villus atrophy and intestinal morphology impairment caused by LPS challenge. Arg (0.5%) supplementation increased the numbers of IgA-secreting cells, CD8(+) and CD4(+) T cells in the ileum (P < 0.05). Arg supplementation prevented the elevation of mast cell numbers induced by LPS challenge (P < 0.05). Dietary supplementation of Arg caused a decreased lymphocyte apoptosis of Peyer's patches in pigs challenged by LPS (P < 0.05). These results indicated that Arg supplementation protects and enhances intestinal mucosal immune barrier function and maintains intestinal integrity in weaned pigs after E. coli LPS challenge.

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“…243 Moreover, NO has a protective function in the development of lesions associated with intestinal allergic reactions, and can enhance survival in anaphylactic reactions. 244 Evidence suggests that low levels of NO produced by intestinal mucosal MCs facilitate maintenance of the epithelial barrier, whereas elevated levels of NO released from macrophages result in intestinal epithelial damage. This is consistent with well-known, dose-dependent effects of NO and the particular isoform of NOS involved.…”

Section: Reactive Oxygen and Reactive Nitrogen Speciesmentioning

confidence: 99%

Advances in mast cell biology: new understanding of heterogeneity and function

et al. 2010

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Mast cells are classically viewed as effector cells of IgE-mediated allergic diseases. However, over the last decade our understanding has been enriched about their roles in host defense, innate and adaptive immune responses, and in homeostatic responses, angiogenesis, wound healing, tissue remodeling, and immunoregulation. Despite impressive progress, there are large gaps in our understanding of their phenotypic heterogeneity, regulatory mechanisms involved, and functional significance. This review summarizes our knowledge of mast cells in innate and acquired immunity, allergic inflammation and tissue homeostasis, as well as some of the regulatory mechanisms that control mast cell development, phenotypic determination, and function, particularly in the context of mucosal surfaces.

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Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide

Cited by 7 publications

References 39 publications

Edematogenic Activity of Scorpion Venoms from the Buthidae Family and the Role of Platelet-Activating Factor and Nitric Oxide in Paw Edema Induced by Tityus Venoms

Edematogenic Activity of Scorpion Venoms from the Buthidae Family and the Role of Platelet-Activating Factor and Nitric Oxide in Paw Edema Induced by Tityus Venoms

Effect of l-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge

Advances in mast cell biology: new understanding of heterogeneity and function

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