“…Primary small bowel neoplasms constitute 1-5% of all tumors and less than 2% of the malign lesions located at the digestive tube, with a population incidence of 1.6/100,000 (2,10) . Concerning the relative rarity of small bowel tumors, compared with esophagus, stomach and colon tumors, many possible explanations have been speculated: (1) fluid content; (2) rapid intestinal transit; (3) alkaline pH; (4) lower bacterial population than in colon and difference in bacterial metabolism; (5) high concentration of immunoglobulin A, particularly in the ileum; (6) possible cytogenetic factors; (7) rapid proliferation and replacement of mucosa; and (8) stem-cells with more efficient apoptosis than in colon for removal of genetically modified cells (1,4,7,14,16) .…”