Small Cell Carcinoma of the Bladder

Yamaguchi, Tadanori; Imamura, Yoshiaki; Shimamoto, Tomoko; Kawada, Takako; Nakayama, Keizou; Tokunaga, Shuji; Yasuda, Michiyuki

doi:10.1159/000328487

Cited by 16 publications

(7 citation statements)

References 17 publications

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“…A review of the cytology literature revealed only few series or anecdotal cases of primary SMCC of the urinary bladder [1,2,3,4,5]. In this report we emphasize that the presence of SMCC cells in urine cytology specimens does not necessarily imply their origin from the urinary bladder.…”

Section: Discussionmentioning

confidence: 72%

“…SMCC in well-preserved urine samples has a distinct cytologic appearance which is similar to that seen in cytology specimens from pulmonary SMCC; however, the appearance of small, dark monomorphic cells in urine specimens is unexpected, and a definite diagnosis of SMCC may require immunocytochemical or ultrastructural confirmation of neuroendocrine differentiation [2,3]. The main differential diagnosis for an SMCC detected in a urine specimen includes urothelial carcinoma in situ, high-grade urothelial carcinoma, and urinary bladder lymphoma, primary or secondary [1,2,3,4,5,10].…”

Section: Discussionmentioning

confidence: 99%

“…The main differential diagnosis for an SMCC detected in a urine specimen includes urothelial carcinoma in situ, high-grade urothelial carcinoma, and urinary bladder lymphoma, primary or secondary [1,2,3,4,5,10]. Cytologically, most in situ urothelial carcinomas show small cells with occasional larger malignant cells that are characterized by hyperchromatic, pleomorphic nuclei with coarsely condensed chromatin in a background of a few inflammatory cells and with no evidence of necrosis [4].…”

Section: Discussionmentioning

confidence: 99%

“…The distinction between primary and metastatic SMCC based on urine cytology alone in many cases cannot be established with certainty and requires clinicopathologic correlation [1,2,3,4,5]. We report an unusual case of ovarian SMCC, the tumor cells of which were detected in a voided urine specimen.…”

Section: Introductionmentioning

confidence: 99%

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Small Cell Carcinoma of the Ovary Presenting in a Urine Cytology Specimen: A Case Report

et al. 2011

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Background: Small cell carcinoma (SMCC) is rarely diagnosed in urine specimens. Cytologically, this tumor is similar to pulmonary SMCC. However, clinicopathologic correlation may be required to differentiate between primary urinary bladder SMCC and metastatic SMCC from a remote primary or secondary bladder involvement by direct extension of the tumor from nearby organs (prostate, uterus, or ovary). A unique case of a rare pulmonary-type ovarian SMCC, the tumor cells of which were detected in a voided urine specimen, is described herein. Case: A 79-year-old female presented to the urologic clinic with a history of metastatic SMCC of unknown primary with hematuria. The voided urine specimen examination revealed tumor cells cytomorphologically consistent with small cell neuroendocrine carcinoma. Following cytologic diagnosis, cystoscopic examination and bladder biopsy were performed. The histopathology revealed a widely invasive tumor with a morphology typical of SMCC. The overlying urothelium was unremarkable. By immunohistochemistry, tumor cells were found positive for neuroendocrine markers, EMA and WT-1. The morphologic and immunohistochemical features of the tumor were most consistent with urinary bladder involvement by pulmonary-type primary ovarian SMCC. Conclusion: It is justified to think that SMCC cell detection in urine specimens does not necessarily imply their origin from primary bladder malignancy. Performing additional studies may be prudent in order to exclude secondary involvement of the bladder in this tumor as the correct diagnosis has significant clinical implications.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Small Cell Carcinoma of the Ovary Presenting in a Urine Cytology Specimen: A Case Report

et al. 2011

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“…8A, B) in which nuclear molding may be apparent. 66,67 In some cases, extensive degeneration increases the proportion of cells displaying pyknotic nuclei and apoptotic debris, which may lead to misinterpretation as an inflammatory infiltrate if other morphologic features suggestive of malignancy (mitotic figures, large cells, background necrosis) are not recognized in the sample. 67,68 While these morphologic features may raise the concern for involvement by a SCNC, there could be a high degree of morphologic overlap with CUC.…”

Section: Small Cell Neuroendocrine Carcinomamentioning

confidence: 99%

An Approach to Nonurothelial Malignancies of the Urinary Bladder in Urine Cytology

Lew

2022

Advances in Anatomic Pathology

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Urine cytology is an economical and convenient method of triaging patients who present with urinary symptoms as well as surveying those who have previously been diagnosed with urothelial carcinoma for recurrent or persistent disease. While the vast majority of malignancies diagnosed in urine cytology are urothelial carcinomas, it is important to recognize nonurothelial elements to inform patient prognosis and raise the possibility of involvement by a urothelial carcinoma variant, nonurothelial malignancy of the bladder, or a nonbladder primary, which may alter patient management pathways. As such, becoming familiar with morphologic features of nonurothelial malignancies in urine cytology as well as their related clinical risk factors, radiologic and cystoscopic features, differential diagnostic considerations, and the utility and pitfalls of ancillary tests can facilitate optimal patient care.

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