Small cell carcinoma of the gallbladder: Report of two cases

Chuang, Shih‐Sung; Lin, Ching-Nan; Chu, Chien-Hui; Chen, Fen-Fen

doi:10.1053/paor.1999.0216

Cited by 15 publications

(5 citation statements)

References 8 publications

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“…Interestingly, there are no neuroectodermal cells in the gallbladder mucosa [12]. This had lead investigators to postulate that the small cell carcinoma arises from metaplastic epithelium of the gallbladder wall [13]. This hypothesis is supported by the presence of metaplasia in the gallbladder with chronic cholecystitis [14].…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Small Cell Carcinoma of the Gallbladder

Nau

Liu

Dillhoff

et al. 2010

Case Reports in Medicine

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Small cell carcinoma of the gallbladder is a rare disease process with approximately 40 cases reported in the literature. It is most often found in elderly female population and is associated with cholelithiasis and cigarette smoking. A multidisciplinary approach to treatment with wide surgical resection and adjuvant chemotherapy is the current standard of care. Notwithstanding prompt medical intervention, it is a disease with a poor prognosis. The pathology is characterized by early metastases and extensive local invasion. Herein, we report two cases of small cell carcinoma addressed at our institution. In both cases, a radical resection was performed with subsequent referral to oncology for additional therapy.

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Section: Discussionmentioning

confidence: 99%

Two Cases of Small Cell Carcinoma of the Gallbladder

Nau

Liu

Dillhoff

et al. 2010

Case Reports in Medicine

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“…One patient received etoposide alone [ 14 ]. One patient received cyclophosphamide, vincristine, procarbazine, and prednisolone [ 22 ]. Two patients underwent chemotherapy with unnamed agents [ 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

Small Cell Carcinoma of the Gallbladder: Case Report and Comprehensive Analysis of Published Cases

Carrera

Kunk

Rahma

2015

Journal of Oncology

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Background. Gallbladder small cell carcinoma is a rare and highly aggressive malignancy with no established standard of care treatment. We described here a case report of small cell gallbladder cancer and we then performed a comprehensive review of 72 case reports of this disease. Methods. Published case reports of small cell carcinoma of the gallbladder between 1983 and 2014 were reviewed. Treatment modalities and survival were analyzed for metastatic and localized disease. Results. Median overall survival for all patients was 13 months. Metastatic disease was identified in 72% of cases. Treatment of metastatic disease with chemotherapy showed a significant survival benefit (p < 0.001) compared to no chemotherapy, and the use of platinum doublet with etoposide showed a nonsignificant 4-month improvement in survival compared to other chemotherapy regimens (p = 0.13). Adjuvant therapy did not demonstrate an improvement of median overall survival in local disease (p = 0.78). Conclusion. Given the limited available data, systemic therapy with platinum and etoposide should be considered for patients with metastatic small cell carcinoma of the gallbladder. Adjuvant chemoradiation or chemotherapy for treatment of local disease warrants further investigation.

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“…7 This has led investigators to postulate that SCC arises from the metaplastic epithelium of the gallbladder wall. 8 This tumor may be secretory with symptoms arising due to the production of biologically active peptides. 13 15 Given the similar pathology and perhaps biology of SCC of the lung and gastrointestinal tract, it is not surprising that platinum agents in combination with etoposide provide the most survival benefits.…”

Section: Casementioning

confidence: 99%

Chemotherapy for Small Cell Carcinoma of Gallbladder: A Case Report

Shin¹,

Lee²,

Oh³

et al. 2018

Korean J Pancreas Biliary Tract

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Small cell carcinoma (SCC) of the gallbladder is a rare disease. It is an aggressive tumor that tends to metastasis early and is associated with poor prognosis. Median overall survival is reported to be approximately 13 months. Metastatic disease has a worse prognosis, and median overall survival is reported to be approximately 4 months. A 65-year-old male patient was diagnosed with the SCC of the gallbladder and was treated with cisplatin/etoposide chemotherapy followed by radiation therapy. Here, we describe the case of the SCC of the gallbladder who survived more than 3 years followed by the review of the literatures on this disease.

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Small cell carcinoma of the gallbladder: Report of two cases

Cited by 15 publications

References 8 publications

Two Cases of Small Cell Carcinoma of the Gallbladder

Two Cases of Small Cell Carcinoma of the Gallbladder

Small Cell Carcinoma of the Gallbladder: Case Report and Comprehensive Analysis of Published Cases

Chemotherapy for Small Cell Carcinoma of Gallbladder: A Case Report

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