Small Cell Carcinoma of the Upper Urinary Tract: A Case Report and Review of Existing Cases

Alevizopoulos, Aristeidis; Yuen, Huay Shan

doi:10.4172/2165-7920.1000811

Cited by 2 publications

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“…Ouzzane et al [ 4 ] reviewed 39 cases and noted that a platinum and etoposide adjuvant regimen increased survival as compared to surgery alone in patients with EPSCC of the upper urinary tract, but this difference was not statistically significant. However, many case reports and single-institution experiences have shown a significant increase in median survival with chemotherapy [ 3 , 4 , 7 , 8 , 9 , 10 , 11 ]. Dakhil et al [ 3 ] reviewed 35 cases from the University of Kansas tumor registry and found that a platinum-based agent with etoposide improved median survival to 36 months compared to 5 months without chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…EPSCC of the upper urinary tract, in particular, has had no more than 40 cases reported in the literature [ 4 , 5 ]. The current knowledge of these rare tumors is limited, and treatment recommendations are mainly based on case reports, single-institution case series, or the extrapolation of results from pulmonary SCC [ 1 , 3 , 4 , 5 , 6 , 7 , 8 ]. No consensus guideline exists, and further work is necessary to better our understanding of how to best manage these patients.…”

Section: Introductionmentioning

confidence: 99%

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Small Cell Cancer of the Genitourinary Tract: A Case Report and Review of the Literature

et al. 2017

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Small cell carcinoma of the urinary tract is an extremely rare disease with very few cases reported in the literature. Its clinical course is aggressive, and the prognosis is poor. Here, we present a case of metastatic extrapulmonary small cell carcinoma of the upper urinary tract in a 74-year-old African-American male. He initially presented with gross hematuria, 20-pound weight loss, and abdominal pain for 2 months. CT imaging showed a 14.0 × 7.0 × 16.0 cm retroperitoneal mass within the left renal fossa; biopsy revealed a carcinoma which was positive for synaptophysin and chromogranin. The patient also had detectable neuroendocrine cells in his urine cytology, confirming the diagnosis of small cell carcinoma. He was treated with carboplatin and etoposide as extrapolated from the treatment of its pulmonary counterpart. Due to the rarity of urinary tract small cell carcinoma, no randomized studies exist to guide therapy or management.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Small Cell Cancer of the Genitourinary Tract: A Case Report and Review of the Literature

et al. 2017

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Primary small cell carcinoma of the ureter

et al. 2018

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Rationale:Primitive small cell carcinoma of the ureter is extremely rare, in this case report is meticulously described its aggressive clinical course and the pathological clues that help with the diagnosis. Also, a detailed table with the clinico-pathological features of analogous case reports in literature is provided.Patient concerns:A 79-year-old female presented with gross hematuria and flank pain.Diagnoses:Small cell carcinoma of the ureter. The surgical specimen showed a mixed histology of small cell carcinoma and transitional cell carcinoma; the common neuroendocrine markers (chromogranin A, synaptophysin, CD56) were positive, and vimentin and thyroid transcription factor 1 were negative. The patient had an advanced stage at presentation with regional nodes involvement (pT3N1).Interventions:Segmental ureterectomy was performed but it was only possible to administer 1 cycle of platinum-based adjuvant chemotherapy due to the rapid decline of her clinical parameters.Outcomes:The disease rapidly spread locally and metastasized.Lesson:The clinicians must be aware of this aggressive tumor with silent clinical course and advanced stages at presentation.

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Small Cell Carcinoma of the Upper Urinary Tract: A Case Report and Review of Existing Cases

Cited by 2 publications

References 6 publications

Small Cell Cancer of the Genitourinary Tract: A Case Report and Review of the Literature

Small Cell Cancer of the Genitourinary Tract: A Case Report and Review of the Literature

Primary small cell carcinoma of the ureter

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