Small cell carcinoma of the head and neck

Baugh, Reginald F.; Wolf, Gregory T.; McClatchey, Kenneth D.

doi:10.1002/hed.2890080505

Cited by 68 publications

(34 citation statements)

References 38 publications

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“…There were too few numbers to examine the role of surgery in the early stage patients. The improved survival compared to other disease sites, may be due to an observation noted by Baugh et al, that sinonasal small cell carcinomas tend to recur locally rather than as distant metastases, compared to laryngeal and pharyngeal sites [23]. The shortest overall survival was observed in patients with small cell carcinoma of the nasopharynx with a median survival of 15.1 months.…”

Section: Discussionmentioning

confidence: 99%

Small cell carcinoma of the head and neck: An analysis of the National Cancer Database

et al. 2017

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Purpose/Objective(s) To evaluate treatment trends and overall survival of patients with small cell carcinoma of the head and neck region. Materials/Methods Patients from 2004–2012 were identified from the National Cancer Database. Patient demographics and overall survival were analyzed. Multivariable analysis was used to identify predictors of survival. Results Among 347,252 head and neck patients a total of 1,042 (0.3%) patients with small cell carcinoma were identified. 17% of patients were diagnosed as stage I/II, 61% as stage III/IVA/IVB and 22% as stage IVC disease. The distribution by anatomic site was 9% oral cavity, 12% oropharynx, 35% larynx, 4% hypopharynx, 10% nasopharynx and 30% nasal cavity and paranasal sinuses. The median overall survival by anatomical site was 20.8 months for oral cavity, 23.7 months for oropharynx, 17.9 months for larynx/hypopharynx, 15.1 months for nasopharynx and 36.4 months for nasal cavity primary tumors. On multivariable analysis across stage, patients with nasal cavity and paranasal sinuses tumors had the best survival and patients with nasopharynx primaries had the worst survival. In stage I/II patients, type of treatment delivered resulted in no overall survival difference (p=0.78). In patients with locally advanced disease, there was no difference in survival between those treated with combined surgery, radiotherapy and chemotherapy compared to those treated only with radiotherapy and chemotherapy (p=0.46). The addition of radiotherapy to chemotherapy in the metastatic setting did not result in improved survival (p=0.14). Conclusions Small cell carcinoma of the head and neck is a rare malignancy with a poor prognosis. The addition of surgery to radiotherapy and chemotherapy did not improve survival in patients with locally advanced disease.

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Section: Discussionmentioning

confidence: 99%

Small cell carcinoma of the head and neck: An analysis of the National Cancer Database

et al. 2017

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“…The role of staging in small cell neuroendocrine tumours is less clear and has not been shown to correlate well with overall survival [9]. Our patient had metastases to ipsilateral lymph nodes at the time of diagnosis, but no evidence of metastatic disease elsewhere.…”

Section: Discussionmentioning

confidence: 78%

“…An early study by Baugh et al . reported comparative medial survival rates of up to 19 months in those who received chemotherapy, compared with 11 months in those who did not receive any chemotherapy [9]. …”

Section: Discussionmentioning

confidence: 99%

A rare case and literature review of primary neuroendocrine carcinoma of the tongue

Singla

Gallagher

2014

Journal of Surgical Case Reports

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Neuroendocrine tumours are rare and have been reported to arise in a number of structures within the head and neck. We present the case of a 55-year-old lady who presented a T1-N2-M0 neuroendocrine tumour of the tongue and right level 2A lymphadenopathy. The patient underwent a partial right-sided glossectomy and a modified radical neck dissection. Given the rarity of small cell neuroendocrine tumours of the tongue, there is some ambiguity with respect to classification. Treatment for neuroendocrine tumours is most effective with a multimodality approach and a poor response to chemotherapy is an important prognostic indicator. Radiotherapy, combined with chemotherapy, has shown the most promise with complete resolution of the primary tumour and metastatic disease. Due to the rarity of neuroendocrine tumours and the lack of favourable prognostic indicators, defining optimal treatment remains difficult. As a result, they continue to have a poor overall prognosis.

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“…In EPSCC of the head and neck, tracheal small-cell carcinoma shows the worst prognosis, laryngeal and hypopharyngeal small-cell carcinomas have intermediate survival, while those of the nose, paranasal sinuses, and parotid gland have the best prognosis. The lungs, liver, and bone are the common sites for distant metastases from head and neck small-cell carcinomas [11]. …”

Section: Discussionmentioning

confidence: 99%

Primary Small-Cell Carcinoma of the Palate with Cushing’s Syndrome: A Case Report

Song

Lin

Chen

et al. 2012

Case Reports in Oncological Medicine

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We report a 24-year-old woman presenting with a relapsed soy-bean-size tender mass at the junction of the soft and hard palate and a history of palatine tumor of small cell carcinoma. Reexcision surgery was performed and histopathological features were consistent. The patient was treated with six cycles of chemotherapy consisting of etoposide and cisplatin. After one year, the patient developed bone metastases and Cushing's syndrome, and successfully recovered with subsequent chemotherapy with irinotecan and cisplatin plus radiotherapy. There was no evidence of recurrence or metastasis for more than three years. Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and has a poor prognosis. This is the first case report of a patient with relapsed primary small cell carcinoma of the palate and successfully treated with second-line chemotherapy and local radiotherapy.

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Small cell carcinoma of the head and neck

Cited by 68 publications

References 38 publications

Small cell carcinoma of the head and neck: An analysis of the National Cancer Database

Small cell carcinoma of the head and neck: An analysis of the National Cancer Database

A rare case and literature review of primary neuroendocrine carcinoma of the tongue

Primary Small-Cell Carcinoma of the Palate with Cushing’s Syndrome: A Case Report

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