Small cell carcinoma of the oesophagus: a rare cause of dysphagia

Schuerle, Theresa; Aoun, Elie; Farah, Katie

doi:10.1136/bcr-2013-200468

Cited by 5 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…World Health Organization histological criteria (2004) for small cell lung cancer (SCLC) or SCEC include small, round, oval or spindle-shaped cells with scant cytoplasm, ill-defined cell borders, finely granular nuclear chromatin, and absent or inconspicuous nucleoli. IHC shows positive expression of the tumor markers CK8, AE1/AE3, EMA, Syn, NSE, CD56, Cg-A, and TTF-1[ 3 , 10 , 11 ]. Wang et al [ 10 ] showed that high Ki-67 expression was an independent favorable prognostic factor for PSCEC patients[ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with stage IIB/III disease who receive CT have a better MST than patients without CT (13.0 mo vs 6.1 mo), while those who receive CT combined with RT have a longer MST than patients who receive surgery combined with CT (25.7 mo vs 12.3 mo)[ 16 ]. CT can greatly improve the survival time of patients with stage III and IV disease[ 3 ]. The MST of patients with stage IV disease after CT is three times that of patients who don’t receive CT.…”

Section: Discussionmentioning

confidence: 99%

“…Primary small cell esophageal carcinoma (PSCEC) is a rare disease, accounting for only 0.8% to 3.1% of all esophageal malignancies[ 1 , 2 ]. The first case was reported in 1952 by McKeown, at present, only about 300 cases of PSCEC have been reported in the world medical literature[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary small cell esophageal carcinoma, chemotherapy sequential immunotherapy: A case report

Wu¹,

Zhang²,

Chen³

et al. 2021

WJCC

View full text Add to dashboard Cite

BACKGROUND Primary small cell esophageal carcinoma (PSCEC) is aggressive and rare, with a worse prognosis than other subtypes esophageal carcinoma. No definitive and optimum standard guidelines are established for treating it. Herein, we report a case of PSCEC, including a current literature review of PSCEC. CASE SUMMARY A 79-year-old male was diagnosed PSCEC with multiple lymph node metastasis thorough computed tomography, positron emission tomography-computed tomography, endoscopy and pathology. Surgery was not suitable for this patient. He was treated with etoposide 100 mg/m 2 and cisplatin 25 mg/m 2 on days 1-3, every 3 wk for 4 cycles. The tumor and lymph nodes became smaller and dysphagia and vomiting symptoms improved. The patient could not tolerate subsequent chemotherapy (CT) because of hematological toxicity; therefore, we performed immunotherapy (durvalumab, 1500 mg) every 4 wk. At present the patient has received 12 cycles immunotherapy over about 1 year. He is still receiving treatment and follow-up. CONCLUSION PSCEC with multiple lymph nodes metastasis does not always indicate surgery. CT may extend survival time and improve the quality of life in the absence of surgery. Immunotherapy or immunotherapy plus CT may also work as a treatment for PSCEC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary small cell esophageal carcinoma, chemotherapy sequential immunotherapy: A case report

Wu¹,

Zhang²,

Chen³

et al. 2021

WJCC

View full text Add to dashboard Cite

show abstract

“…Management consists of surgical esophagectomy in limited disease [ 8 , 9 ] and systemic chemotherapy in metastatic disease [ 10 ]. Few cases of PSSCE have been reported in the literature [ 11 – 13 ]. This report describes the case of a 36-year-old man presenting with epigastric pain, dysphagia, and melena due to a primary esophageal small cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Epigastric Pain and Dysphagia in a 36-Year-Old Man Due to Primary Esophageal Small Cell Carcinoma

Aijaz,

Niazi,

Chela

et al. 2024

Am J Case Rep

View full text Add to dashboard Cite

Patient: Male, 36-year-old Final Diagnosis: Primary small cell carcinoma of the esophagus Symptoms: Dysphagia • epigastric pain Clinical Procedure: — Specialty: Gastroenterology and Hepatology • Oncology Objective: Rare disease Background: Small cell carcinoma is an aggressive malignant neuroendocrine tumor that most commonly occurs in the lung. Primary small cell carcinoma of the esophagus (PSCCE) is rare and is an aggressive malignancy with poor prognosis and no clear management guidelines. This report describes the case of a 36-year-old man presenting with epigastric pain, dysphagia, and melena due to a primary esophageal small cell carcinoma. Case Report: A 36-year-old presented to the Emergency Department (ED) with epigastric pain associated with food intake. Initial workup was unremarkable, and a presumed clinical diagnosis of reflux esophagitis and peptic strictures was made, prompting empiric treatment with anti-secretory therapies. Despite these therapies, he presented to the emergency room with progressively worsening dysphagia. Endoscopic examination (EGD) revealed a large necrotic mass, and computed tomography (CT) imaging revealed liver metastasis. Biopsies from both the liver and esophageal masses confirmed small cell carcinoma. His clinical course was complicated by a broncho-esophageal fistula, leading to massive hemoptysis, necessitating intubation. Unfortunately, his condition deteriorated rapidly, and he chose to pursue hospice care. He died 3 months after his initial presentation. Conclusions: This report has presented a rare case of primary esophageal small cell carcinoma and our approach to management. We highlight the importance of early diagnosis, supported by histopathology, and the need for management guidelines.

show abstract

Carboplatin/etoposide/topotecan

2014

Reactions Weekly

View full text Add to dashboard Cite

Small cell carcinoma of the oesophagus: a rare cause of dysphagia

Cited by 5 publications

References 11 publications

Primary small cell esophageal carcinoma, chemotherapy sequential immunotherapy: A case report

Primary small cell esophageal carcinoma, chemotherapy sequential immunotherapy: A case report

Epigastric Pain and Dysphagia in a 36-Year-Old Man Due to Primary Esophageal Small Cell Carcinoma

Carboplatin/etoposide/topotecan

Contact Info

Product

Resources

About